
Cheng Laboratory
Xiaodong Cheng, Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Cheng Laboratory
Areas of Research
- Epigenetics
- DNA Methylation
Our Research
The Cheng laboratory is defining the structural and biological effects of epigenetic modifications on DNA and histones.
Notable Publications
Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, Sherk C, Wong K, Pathuri S, Briand J, Steidel M, Chapman P, Groy A, Wiseman AK, McHugh CF, Campobasso N, Graves AP, Fairweather E, Werner T, Raoof A, Butlin RJ, Rueda L, Horton JR, Fosbenner DT, Zhang C, Handler JL, Muliaditan M, Mebrahtu M, Jaworski JP, McNulty DE, Burt C, Eberl HC, Taylor AN, Ho T, Merrihew S, Foley SW, Rutkowska A, Li M, Romeril SP, Goldberg K, Zhang X, Kershaw CS, Bantscheff M, Jurewicz AJ, Minthorn E, Grandi P, Patel M, Benowitz AB, Mohammad HP, Gilmartin AG, Prinjha RK, Ogilvie D, Carpenter C, Heerding D, Baylin SB, Jones PA, Cheng X, King BW, Luengo JI, Jordan AM, Waddell I, Kruger RG, McCabe MT. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021 Oct;2(10):1002-1017.
Zhou J, Horton JR, Blumenthal RM, Zhang X, Cheng X. Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix. Nat Commun. 2021 Jun 8;12(1):3436.
Zeng Y, Ren R, Kaur G, Hardikar S, Ying Z, Babcock L, Gupta E, Zhang X, Chen T, Cheng X. The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation. Genes Dev. 2020 Nov 1;34(21-22):1546-1558.
Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X. The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site. Nat Commun. 2019 Oct 10;10(1):4600.
Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X. Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun. 2019 Aug 6;10(1):3541.
Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X DNA Conformation Induces Adaptable Binding by Tandem Zinc Finger Proteins. Cell. 2018 Mar 22;173(1):221-233.e12.
Hashimoto H., Wang, D., Horton, J.R., Zhang, X., Corces, V.G., Cheng, X Structural Basis for the Versatile and Methylation-Dependent Binding of CTCF to DNA. Mol Cell. 2017 Jun 1;66(5):711-720.e3.
Contact Us
The University of Texas MD Anderson Cancer Center
Department of Epigenetics and Molecular Carcinogenesis, Unit 1000
Mailing Address: 1515 Holcombe Blvd., Houston, TX 77030
Physical Address: 6767 Bertner Ave., Houston, TX 77030
Xiaodong Cheng, Ph.D.
Principal Investigator
xcheng5@mdanderson.org
Tracy Saegert
Administrative Contact
713-794-1963
tmsaegert@mdanderson.org
Laura Denton
Grants Contact
Phone: 713-563-7445
lmdenton@mdanderson.org