
Arur Laboratory
Swathi Arur, Ph.D.
Principal Investigator
Areas of Research
- Developmental Biology
- miRNAs
- ncRNAs
- Nutrition
- Meiosis
- Cancer Metastasis
Welcome to the Arur Laboratory. We use multidisciplinary approaches and model systems with a goal to gain knowledge into three specific biological questions. We hope to understand the basis of (i) environmental signaling and its role in female and male fertility, (ii) signaling and control of birth defects, with specific focus on Ras pathway and (iii) signaling-based control of post-transcriptional regulation on cancer metastasis.
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Research Focus
- Female and male germ cell development primarily in C. elegans
- Role of Ras signaling on embryonic morphogenesis in C. elegans
- Mechanisms of cancer progression and metastasis using mouse models and human cultured cells.
Research projects in the Arur Laboratory are focused on the following major areas:
- Unraveling the environmentally regulated mechanisms and molecules that control meiotic I progression in female germ cells. We use C. elegans as our model system for this work.
- Determining the role of small RNA pathways and post-transcriptional regulation during male and female germ cell development in C. elegans.
- Understanding the role of Ras signaling during embryonic morphogenesis in C. elegans.
- Identifying principles that regulate tumor progression upon signal-mediated regulation of post-transcriptional regulation rather than through the increase in mutational burden. We use mouse and cultured cells as models for this work.
Explore the various links on our web page and get to know us and our research.We welcome discussions; please contact us using our email address.
Meet the Team
From left to right: Nick Newkirk, Amelia Hongyuan, Jacob Ortega, Raisa Reyes Castro,, Tokiko Furuta, Angie Maldonado, Deba Das, Swathi Arur (PI), Jacob Seeman, Kenneth Trimmer, Han Bit Baek, Shin-Yu Chen
Arur Lab News
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August 16, 2023
Congratulations to Dr. Kenny Trimmer for being selected as the Trainee Speaker representing the TPEHS Training Program at the upcoming Keck Annual Research Conference on October 20, 2023, sponsored by the Gulf Coast Consortium.
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August 2, 2023
Congratulations to Nick Newkirk for successfully renewing the American Legion Auxiliary Fellowship in Cancer Research awarded by the Dean’s office at UT MD Anderson UTHealth Graduate School of Biomedical Sciences.
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July 26, 2023
Science Advances Article Opens a new window
Congratulations to Raisa Reyes, whose work on the role of phosphorylated nuclear Dicer in lineage reprogramming as a mechanism to drive tumor progression was published today in Science Advances.
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June 20, 2023
Congratulations to Nick Newkirk for receiving the 2023 G&E student service award.
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May 23, 2023
Read about the work here:
Congratulations to Dr. Kenny Trimmer on his latest work published at Cell Reports, where he identified transcripts that are acquired by arrested oocytes from neighboring somatic cells.