
Arur Laboratory
Swathi Arur, Ph.D.
Principal Investigator
Areas of Research
- Developmental Biology Research
- miRNAs Research
- ncRNAs Research
- Nutrition Research
- Meiosis
- Cancer Metastasis Research
Welcome to the Arur Laboratory. We use multidisciplinary approaches and model systems with a goal to gain knowledge into three specific biological questions. We hope to understand the basis of (i) environmental signaling and its role in female and male fertility, (ii) signaling and control of birth defects, with specific focus on Ras pathway and (iii) signaling-based control of post-transcriptional regulation on cancer metastasis.
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Research Focus
- Female and male germ cell development primarily in C. elegans
- Role of Ras signaling on embryonic morphogenesis in C. elegans
- Mechanisms of cancer progression and metastasis using mouse models and human cultured cells.
Research projects in the Arur Laboratory are focused on the following major areas:
- Unraveling the environmentally regulated mechanisms and molecules that control meiotic I progression in female germ cells. We use C. elegans as our model system for this work.
- Determining the role of small RNA pathways and post-transcriptional regulation during male and female germ cell development in C. elegans.
- Understanding the role of Ras signaling during embryonic morphogenesis in C. elegans.
- Identifying principles that regulate tumor progression upon signal-mediated regulation of post-transcriptional regulation rather than through the increase in mutational burden. We use mouse and cultured cells as models for this work.
Explore the various links on our web page and get to know us and our research.We welcome discussions; please contact us using our email address.
Meet the Team
From left to right: Nick Newkirk, Amelia Hongyuan, Jacob Ortega, Raisa Reyes Castro,, Tokiko Furuta, Angie Maldonado, Deba Das, Swathi Arur (PI), Jacob Seeman, Kenneth Trimmer, Han Bit Baek, Shin-Yu Chen
Arur Lab News
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May 23, 2023
Read about the work here:
Congratulations to Dr. Kenny Trimmer on his latest work published at Cell Reports, where he identified transcripts that are acquired by arrested oocytes from neighboring somatic cells.
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May 20, 2023
Congratulations to Dr. Deba Das for being invited as a speaker at the Annual Frontiers in Reproduction Alumni symposium at Marine Biological Labs to be held in June, 2023.
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May 15, 2023
Congratulations to Raisa for successfully defending her Ph.D. thesis!
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May 2, 2023
Check out the latest work from Tokiko Furuta in the lab.
Tokiko identified a role for sart-3, a splicosomal component, in regulating germline sex determination in C. elegans.
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May 1, 2023
We welcome Janet Cheng to the lab as a Masters student in the Graduate Program in Diagnostic Genetics and Genomics, MD Anderson Cancer Center.