Arur Laboratory
Swathi Arur, Ph.D.
Principal Investigator
Research Focus
Investigation in the Arur Lab utilizes the nematode Caenorhabditis elegans and germ line development to study ERK signaling. A long-term goal of the lab is to understand how active ERK2 controls and co-ordinates multiple different developmental events in one tissue.
Meet the team
From left to right: Shin-Yu Chen, Tokiko Furuta, Swathi Arur, Charlotte Lee, Amanda Gervaise, Kenny Trimmer
Selected Publications
Burton NO, Furuta T, Webster AK, Kaplan RE, Baugh LR, Arur S, Horvitz HR. Insulin-like signalling to the maternal germline controls progeny response to osmotic stress. Nat Cell Biol. (2017) 19 (3):252-257 PMCID: PMC5332277
Chen JJ, Arur S. Discovering Functional ERK Substrates Regulating Caenorhabditis elegans Germline Development. Methods Mol Biol. (2017) 1487:317-335. PMID: 27924578.
Gervaise AL, Arur S. Spatial and Temporal Analysis of Active ERK in the C. elegans Germline. J Vis Exp. (2016) 29; (117) PMCID: PMC5226324.
Snee MJ, Wilson WC, Zhu Y, Chen SY, Wilson BA, Kseib C, O'Neal J, Mahajan N, Tomasson MH, Arur S*, Skeath JB. Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras is Conserved Across Species. Genetics. (2016) pii: genetics.116.187930. PMCID: PMC4896191. *Co-Corresponding Author
Mattingly, HH, Chen, J, Arur, S*, Shvartsman, SY. A Transport Model for Estimating the Time Course of ERK Activation in the C. elegans Germline, Biophysical Journal, (2015) 109,11, p2436 - 2445 *corresponding author
Drake, M, Furuta T, Suen KM, Gonzalez G, Liu B, Kalia A, Ladbury JE, Fire AZ, Skeath JB, Arur S. A Requirement for ERK-Dependent Dicer Phosphorylation in Coordinating Oocyte-to-Embryo Transition in C. elegans. Dev Cell (2014) 31, 614-628. PMCID: PMC4261158
Lopez AL 3rd, Chen J, Joo HJ, Drake M, Shidate M, Kseib C, Arur S. DAF-2 and ERK Couple Nutrient Availability to Meiotic Progression during Caenorhabditis elegans Oogenesis Dev Cell. (2013) PMCID: PMC3829605
Arur S, Ohmachi M, Berkseth M, Nayak S, Hansen D, Zarkower D, Schedl T. MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex-determination module. Dev Cell. (2011)17;20(5):677-88. PMCID: PMC3098718
Arur S, Ohmachi M, Nayak S, Hayes M, Miranda A, Hay A, Golden A, Schedl T.Multiple ERK substrates execute single biological processes in Caenorhabditis elegans germ-line development. Proc Natl Acad Sci U S A. (2009)106(12):4776-81. PMCID: PMC2660749