Swathi Arur, Ph.D.
Areas of Research
- Developmental Biology Research
- miRNAs Research
- ncRNAs Research
- Nutrition Research
- Cancer Metastasis Research
Welcome to the Arur Laboratory. We use multidisciplinary approaches and model systems with a goal to gain knowledge into three specific biological questions. We hope to understand the basis of (i) environmental signaling and its role in female and male fertility, (ii) signaling and control of birth defects, with specific focus on Ras pathway and (iii) signaling based control of post-transcriptional regulation on cancer metastasis.
- Female and male germ cell development primarily in C. elegans
- Role of Ras signaling on embryonic morphogenesis in C. elegans
- Mechanisms of cancer progression and metastasis using Mouse models and human cultured cells.
Research projects in the Arur Laboratory are focused on the following major areas:
- Unraveling the environmentally regulated mechanisms and molecules that control meiotic I progression in female germ cells. We use C. elegans as our model system for this work.
- Determing the role of small RNA pathways and post-transcriptional regulation during male and female germ cell development in C. elegans.
- Understand the role of Ras signaling during embryonic morphogenesis in C. elegans.
- Identifying principles that regulate tumor progression upon signal-mediated regulation of post-transcriptional regulation rather than through the increase in mutational burden. We use mouse and cultured cells as models for this work.
Explore the various links on our web page and get to know us and our research.We welcome discussions; please contact us using our email address.
Meet the Team
From left to right: Nick Newkirk, Amelia Hongyuan, Jacob Ortega, Raisa Reyes Castro,, Tokiko Furuta, Angie Maldonado, Deba Das, Swathi Arur (PI), Jacob Seeman, Kenneth Trimmer, Han Bit Baek, Shin-Yu Chen