Swathi Arur, Ph.D.
Areas of Research
- Developmental Biology Research
- miRNAs Research
- ncRNAs Research
- Nutrition Research
- Cancer Metastasis Research
Welcome to the Arur Laboratory. We use multidisciplinary approaches and model systems with the goal to gain knowledge and understanding on principles that regulate female fertility. We focus on meiosis I, which is largely completed in the female fetus in vertebrates. Specifically, we focus on the role of maternal environment and nutrition on progression of female meiosis I, and its impact on birth and development of the progeny.
- Female germ cell development
- Nutritional and environmental signals that coordinate female fertility
- Mechanisms of cancer progression and metastasis
Research projects in the Arur Laboratory are focused on two major areas:
- Unraveling the environmentally regulated mechanisms and molecules that control meiotic I progression in female germ cells. We use C. elegans as our model system for this work.
- Identifying principles and players that regulate tumor progression upon metabolic signaling rather than through the increase in mutational burden. We use mouse and cultured cells as models for this work. These efforts should allow us to identify metabolic checkpoints impeding tumor growth.
Explore the various links on our web page and get to know us and our research.We welcome discussions; please contact us using our email address.
Meet the Team
From left to right: Raisa Castro, Shin-Yu Chen, Charlotte Lee, Jacob Seeman, Jacob Ortega, Swathi Arur, Deb Debabrata, Amanda Minogue, Kenny Trimmer, Tokiko Furuta
Arur Lab News
May 7, 2019
Paper accepted! Amanda Minogue developed an insitu hybridization method to detect miRNAs in vivo in dissected tissue. This method was accepted for publication in Current Protocols in Molecular Biology. Congratulations Amanda!
Han Bit Baek joins the lab as a graduate student! Welcome aboard Han!
April 5, 2019
Congratulations to Amanda for winning the First place in Poster presentation at the Annual Retreat for Program in Developmental Biology, BCM.
March 14, 2019
Congratulations to Kenny on successfully defending his thesis!
March 11, 2019
Our paper showing (a) the constitutive (heterozygous) phospho-Dicer1 drives tumor progression and dissemination in mice and (b) phosphorylated Dicer1 correlates with invasive endometrioid tumors in women, was accepted in Cancer Research! Congratulations to Neeraj Aryal, Gigi Lozano and Paul Goodfellow (OHSU) our awesome collaborators for helping take a discovery made in worms to mouse models and human cancers!
Raisa Castro, an M.D./Ph.D. student joins the lab. Welcome Raisa!
Dec. 5, 2018
Congratulations to Swathi for being elected to the Board of Directors of the Genetics of Society of America.