Swathi Arur, Ph.D.
Areas of Research
- Developmental Biology Research
- miRNAs Research
- ncRNAs Research
- Nutrition Research
- Cancer Metastasis Research
Welcome to the Arur Laboratory. We use multidisciplinary approaches and model systems with the goal to gain knowledge and understanding on principles that regulate female fertility. We focus on meiosis I, which is largely completed in the female fetus in vertebrates. Specifically, we focus on the role of maternal environment and nutrition on progression of female meiosis I, and its impact on birth and development of the progeny.
- Female germ cell development
- Nutritional and environmental signals that coordinate female fertility
- Mechanisms of cancer progression and metastasis
Research projects in the Arur Laboratory are focused on two major areas:
- Unraveling the environmentally regulated mechanisms and molecules that control meiotic I progression in female germ cells. We use C. elegans as our model system for this work.
- Identifying principles and players that regulate tumor progression upon metabolic signaling rather than through the increase in mutational burden. We use mouse and cultured cells as models for this work. These efforts should allow us to identify metabolic checkpoints impeding tumor growth.
Explore the various links on our web page and get to know us and our research.We welcome discussions; please contact us using our email address.
Meet the Team
From left to right: Raisa Castro, Shin-Yu Chen, Charlotte Lee, Jacob Seeman, Jacob Ortega, Swathi Arur, Deb Debabrata, Amanda Minogue, Kenny Trimmer, Tokiko Furuta
Arur Lab News
March 11, 2019
Our paper showing (a) the constitutive (heterozygous) phospho-Dicer1 drives tumor progression and dissemination in mice and (b) phosphorylated Dicer1 correlates with invasive endometrioid tumors in women, was accepted in Cancer Research! Congratulations to Neeraj Aryal, Gigi Lozano and Paul Goodfellow (OHSU) our awesome collaborators for helping take a discovery made in worms to mouse models and human cancers!
Dec. 5, 2018
Paper Accepted! Congratulations to Swathi for being elected to the Board of Directors of the Genetics of Society of America.
Nov. 26, 2018
Paper accepted! Congratulations to Amanda and our team of collaborators Mike Tackett and Elnaz Atabaksh from Abcam on our latest study accepted for publication at Nature Communications. The study identifies a small repertoire of miRNAs that are expressed and functional in meiosis I oocytes. Amanda further finds that over half of these are generated even in the absence of Drosha activity, uncovering new layers of complexity in RNA landscape underlying oocyte development.
Nov. 19, 2018
Paper accepted! Our collaborative paper on the role of constitutive Dicer phosphorylation in accelerating aging and metabolism in mice is accepted at PNAS! Congratulations to Neeraj Aryal and Gigi Lozano on this study and for being awesome collaborators.
Oct. 25, 2018
Congratulations to Amanda on winning the second place for Platform talks at the Baylor Graduate Student Symposium!