MOON SHOT FLAGSHIP PROJECT
Tackling drug resistance
Hypomethylating agents — the most promising drugs available to treat MDS and AML — have long been the standard of care. But for reasons we don’t know, they often stop working. Funding for this project will help us understand, at the molecular level, how these diseases resist treatment. It will also help find new ways to overcome this challenge. Our strategies include analyzing proteins active in AML and MDS and developing new cell lines that are either sensitive to or resistant to hypomethylating agents.