Instrumentation
PyroMark Q96 ID
The PyroMark Q96 uses pyrosequencing technology combined with a 96-well format to provide quantitative analysis of genetic and epigenetic DNA modifications as well as mutation gene expression analysis. It has an automatic base-calling function and dedicated software to aid methylation assay design and analysis.
Illumina MiSeq System
The MiSeq system is used for in-house DNA methylation analysis and QC for ChIP libraries. It is capable of automated paired-end reads and creates up to 15 Gb of output with 25 million sequencing reads and 2 × 300 bp read lengths per run.
Oxford Nanopore GridION
The GridION Mk1 can directly detect modified bases in nucleic acids without intermediate processing. This feature, combined with its ability to generate several kilobases of nucleic acid sequence per sequencing pore, makes it useful in many epigenomic analyses.
Bioruptor Twin Sonicator
A key step for ChIP and next-generation sequencing experiments is precisely controlling shearing of chromatin, DNA, and RNA into appropriately sized fragments. The core has a Diagenode Bioruptor Twin Sonicator that uses "highly-controlled ultrasonic energy with
Covaris ME220 Focused-Ultrasonicator
The Covaris ME220 Focused-ultrasonicator is a mutli-sample, multi-application benchtop sonicator formatted for 1 to 8 sample batch-processing. It is equipped with an integrated chiller and has automated water management. It helps ensure accurate, reproducible, and robust sample preparation.
Agilent 2100 Bioanalyzer
The Agilient 2100 Bioanalyzer performs electophoresis in microchannels to provide sizing, quantitation, and purity assessments for DNA and RNA samples.
Agilent 4200 TapeStation
The Agilent 4200 TapeStation is an automated system providing a rapid, reliable gel electrophoresis platform to assess overall sample quality (e.g. size, quantity