Lymphoma Outcomes SPORE

The program integrates laboratory science, advanced analytics and community collaborations to improve understanding of disease mechanisms and develop practical diagnostic and therapeutic strategies that can be applied in diverse clinical settings.

The SPORE consists of four cores, three research projects and two programmatic initiatives (a Developmental Research Program and a Career Enhancement Program). 

Four cores provide specialized services to support our SPORE investigators and their proposed research studies:

• Core A: Administrative Core
• Core 1: Community Outreach & Engagement Core
• Core 2: Biospecimens & Pathology Core
  
• Core 3: Biostatistics and Bioinformatics Core

Research Projects

• Project 1: Precision Targeting of Therapeutic Vulnerabilities Specific to African Ancestry Lymphoma Patients
  
• Project 2: Translating Genomics to Practice to Improve Outcomes in Diffuse Large B-Cell Lymphoma (DLBCL) 
  
• Project 3: AI Digital Pathology Tools to Improve Lymphoma Diagnosis and Classification

Career Enhancement Program

CEP Director: Christopher Flowers, M.D. M.S., FASCO

The Career Enhancement Program (CEP) supports early-career and established investigators who are dedicated to developing novel and meritorious approaches to address gaps in diagnostic and prognostic accuracy, treatment, surveillance and outcomes for patients with lymphoma. Led by experienced mentors with strong records in funding, team science and cancer outcomes-focused mentorship, the CEP provides structured support, research infrastructure and career development to foster the next generation of leaders in lymphoma outcomes research.

Developmental Research Program

DRP Director: Jean Koff, M.D., M.Sc.

The goal of the Developmental Research Program (DRP) is to support pilot projects that take maximum advantage of the new research opportunities afforded by the SPORE. The DRP will support three to four collaborative, multidisciplinary, translational DRP awards each year that propose highly promising, innovative translational and/or clinical research approaches for addressing poor outcomes in patients with lymphoma. DRP awards are expected to utilize support from one or more of the SPORE Core Facilities, which are crucial to provide the specialized, non-overlapping infrastructure necessary for the successful execution of these lines of research. DRP awards are expected to form a research base for future SPORE projects, supporting state-of-the-art, investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis and treatment in specific patient populations.