In the United States today, 10 million individuals suffer from osteoporosis (porous bone), and almost 34 million more are estimated to have low bone mass, placing them at increased risk for osteoporosis. Anyone over the age of 50 is at risk, making osteoporosis a major public health threat.
Recent advances in treatment regimens for breast and prostate cancer have greatly improved patient survival; however, these therapies can weaken bones. Increasingly, patients who are otherwise cured, or whose cancer is successfully managed for years, are developing osteoporosis at an accelerated rate due to cancer treatment.
Bone metastasis, which occurs most often when breast, prostate, lung, kidney and thyroid cancers spread to bones, is one of the most frequent causes of pain in individuals with cancer. Metastasis to bone is the primary cause of death in prostate cancer.
The Rolanette and Berdon Lawrence Bone Disease Program of Texas, a collaborative research, clinical and education program of Baylor College of Medicine, The University of Texas MD Anderson Cancer Center, and The University of Texas Health Science Center at Houston. The Program was established in 2002 to improve basic and translational research of bone diseases and to convert basic science findings to more effective treatment and prevention options.
- Develop bone-forming treatment for all degenerative bone diseases
- Improve prevention and treatment for bone cancer metastasis
- Foster existing collaborations between the three institutions in this area
Bone Research Club
The Bone Research Club is an informal group of Bone Disease Program of Texas researchers and clinicians that meets to discuss a variety of topics in skeletal biology.
The club meets on the second Wednesday of each month from 6-7:30 p.m. at Third Coast, located in the John P. McGovern Commons Building, for a roundtable discussion and a light dinner.
Please call 713-798-2133 if you are interested in joining.
Events and Announcements
Dr. Theresa Guise joins the Bone Disease Program of Texas as its new Co-Director.
The Bone Disease Program of Texas is pleased to announce that Dr. Theresa Guise succeeds Dr. Robert F. Gagel as Co-Director of the Rolanette and Berdon Lawrence Bone Disease Program of Texas. Dr. Guise has assumed the position of Chief of the Section of Bone and Mineral Disorders in the Department of Endocrine Neoplasia and Hormonal Disorders at MD Anderson Cancer Center.
Dr. Guise joins us from Indiana University School of Medicine, where she was Professor of Medicine and Pharmacology and Co-Leader of the Tumor Microenvironment and Metastasis program at the IU Simon and NCI Comprehensive Cancer Center. Her groundbreaking discoveries in the field of cancer metastases to bone have been widely recognized and have led to therapies benefitting patients world-wide. As a truly innovative scientist who makes seminal contributions to the cancer and bone field in a highly creative and impressive manner, her laboratory has been consistently funded by the National Institutes of Health, Department of Defense, and the Susan G. Komen, Prostate Cancer, and V Foundations.
Dr. Guise is well respected clinician for her expertise in a broad variety of bone and mineral disorders, particularly those affecting patients with cancer. Dr. Guise has been the recipient of numerous honors, including having been elected to the American Society for Clinical Investigation, and chairing the Tumor Microenvironment Steering Committee of the American Association for Cancer Research.
As we welcome Dr. Guise, we thank Dr. Gagel for leading the creation of the Bone Disease Program of Texas in 2002 and for his many years in leadership positions along with Baylor College of Medicine and The University of Texas Health Science Center at Houston. We look forward to Dr. Gagel’s continued participation in the BDPT as the “Emeritus Founding Director” and wish him well in the next chapter.
Congratulations to the First Place Research Award Winners at the 2020 Rolanette and Berdon Lawrence Scientific Retreat!
- Greg Couasnay, Ph.D., Department of Orthopedics, Baylor College of Medicine
“A Revisited Ton EBP Biology Study”
- Trupti B. Trivedi, Ph.D., Department of Endocrine Neoplasia and Hormonal Disorders, MD Anderson Cancer Center
“Role of Bone Derived TGF-B on Glucose Metabolism, Muscle Function and Bone Quality in the Setting of Total Estrogen Deprivation and High Fat Diet”
- Joohyun (Jason) Lim, Ph.D., Department of Molecular and Human Genetics, Baylor College of Medicine
“Investigating the Pathogenic Mechanisms Underlying Bruck Syndrome 1"