Yao Laboratory

Cell

Hear Pancreatic Cancer Stem Cells ROR.

Yao W, Maitra A. Cell 177(3):516-518, 4/2019.

Nature

Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer.

Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Nature 568(7752):410-414, 4/2019. e-Pub 3/2019.

Cell

Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer.

Kapoor A, Yao W (co-first), Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Cell 158(1):185-197, 7/2014. e-Pub 6/2014.

Mol Cancer

Profilin-1 suppresses tumorigenicity in pancreatic cancer through regulation of the SIRT3-HIF1α axis.

Yao W, Ji S, Qin Y, Yang J, Xu J, Zhang B, Xu W, Liu J, Shi S, Liu L, Liu C, Long J, Ni Q, Li M, Yu X. Mol Cancer 13:187, 8/2014. e-Pub 8/2014.

Cancer Res

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition.

Yan L, Tu B, Yao J, Gong J, Carugo A, Bristow C, Wang Q, Zhu C, Dai B, Kang Y, Han L, Feng N, Jin Y, Fleming J, Heffernan T, Yao W (co-corresponding), Ying H. Cancers Res. 2021 Jun 11;canres.3792.2020. doi: 10.1158/0008-5472.CAN-20-3792

Cell Death & Disease

Suppression of tumor angiogenesis by targeting protein neddylation pathway

Yao W, Wu J, Yu G, Wang R, Wang K, Li L, Chen P, Jiang Y, Cheng H, Lee H, Hoffman R, Jeong L, Jia L. Cell Death & Disease, 2/2014.

EBioMedicine

Recent insights into the biology of pancreatic cancer.

Yao W, Maitra A, Ying H. EBioMedicine. 2020 Mar;53:102655

JCI Insight

YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma.

Tu B, Yao J, Ferri-Borgogno S, Zhao J, Chen S, Wang Q, Yan L, Zhou X, Zhu C, Bang S, Chang Q, Bristow CA, Kang Y, Zheng H, Wang H, Fleming JB, Kim M, Heffernan TP, Draetta GF, Pan D, Maitra A, Yao W (co-corresponding), Gupta S, Ying H. JCI Insight 4(21), 11/2019. e-Pub 11/2019.