Selected Publications
#: equal contribution
2022
Drews, R.M., Hernando, B., Tarabichi, M., Haase, K., Lesluyes, T., Smith, P.S., Morrill Gavarró, L., Couturier, D.L., Liu, L., Schneider, M., Brenton, J.D., Van Loo, P., Macintyre, G.#, Markowetz, F.# (2022). A pan-cancer compendium of chromosomal instability. Nature, 606:976-983.
Steele, C.D., Abbasi, A., Islam, S.M.A., Bowes, A.L., Khandekar, A., Haase, K., Hames-Fathi, S., Ajayi, D., Verfaillie, A., Dhami, P., McLatchie, A., Lechner, M., Light, N., Shlien, A., Malkin, D., Feber, A., Proszek, P., Lesluyes, T., Mertens, F., Flanagan, A.M., Tarabichi, M., Van Loo, P., Alexandrov, L.B.#, Pillay, N.# (2022). Signatures of copy number alterations in human cancer. Nature, 606:984-991.
Cao, S.#, Wang, J.R.#, Ji, S.#, Yang, P., Dai, Y., Guo, S., Montierth, M.D., Shen, J.P., Zhao, X., Chen, J., Lee, J.J., Guerrero, P.A., Spetsieris, N., Engedal, N., Taavitsainen, S., Yu, K., Livingstone, J., Bhandari, V., Hubert, S.M., Daw, N.C., Futreal, P.A., Efstathiou, E., Lim, B., Viale, A., Zhang, J., Nykter, M., Czerniak, B.A., Brown, P.H., Swanton, C., Msaouel, P., Maitra, A., Kopetz, S., Campbell, P., Speed, T.P., Boutros, P.C., Zhu, H., Urbanucci, A., Demeulemeester, J., Van Loo, P., Wang, W. (2022). Estimation of tumor cell total mRNA expression in 15 cancer types predicts disease progression. Nature Biotechnology, 40:1624-1633.
Kaufmann, T.L.#, Petkovic, M.#, Watkins, T.B.K.#, Colliver, E.C., Laskina, S., Thapa, N., Minussi, D.C., Navin, N., Swanton, C., Van Loo, P., Haase, K., Tarabichi, M., Schwarz, R.F. (2022). MEDICC2: whole-genome doubling aware copy-number phylogenies for cancer evolution. Genome Biology, 23:241.
Cross, W., Lyskjær, I., Lesluyes, T., Hargreaves, S., Strobl, A.C., Davies, C., Waise, S., Hames-Fathi, S., Oukrif, D., Ye, H., Amary, F., Tirabosco, R., Gerrand, C., Baker, T., Barnes, D., Steele, C., Alexandrov, L., Bond, G.; Genomics England Research Consortium, Cool, P., Pillay, N., Van Loo, P.#, Flanagan, A.M.# (2022). A genetic model for central chondrosarcoma evolution correlates with patient outcome. Genome Medicine, 14:99.
Bowes, A.L., Tarabichi, M., Pillay, N., Van Loo, P. (2022). Leveraging single-cell sequencing to unravel intratumour heterogeneity and tumour evolution in human cancers. The Journal of Pathology, 257:466-478. Review.
Demeulemeester, J., Dentro, S.C., Gerstung, M., Van Loo, P. (2022). Biallelic mutations in cancer genomes reveal local mutational determinants. Nature Genetics, 54:128-133.
2021
Tarabichi, M., Demeulemeester, J., Verfaillie, A., Flanagan, A.M., Van Loo, P.#, Konopka, T.# (2021). A pan-cancer landscape of somatic substitutions in non-unique regions of the human genome. Nature Biotechnology, 39:1589-1596.
Yan, H., Tarabichi, M., McGranahan, N., Van Loo, P. (2021). DeCiFering the subclonal composition of tumors. Cell Systems, 12(10):955-957. Preview.
Dentro, S.C.#, Leshchiner, I.#, Haase, K.#, Tarabichi, M.#, Wintersinger, J.#, Deshwar, A.G.#, Yu, K.#, Rubanova, Y.#, Macintyre, G.#, Demeulemeester, J.#, Vázquez-García, I., Kleinheinz, K., Livitz, D.G., Malikic, S., Donmez, N., Sengupta, S., Anur, P., Jolly, C., Cmero, M., Rosebrock, D., Schumacher, S.E., Fan, Y., Fittall, M., Drews, R.M., Yao, X., Watkins, T.B.K., Lee, J., Schlesner, M., Zhu, H., Adams, D.J., McGranahan, N., Swanton, C., Getz, G., Boutros, P.C., Imielinski, M., Beroukhim, R., Sahinalp, S.C., Ji, Y., Peifer, M., Martincorena, I., Markowetz, F., Mustonen, V., Yuan, K., Gerstung, M., Spellman, P.T., Wang, W.#, Morris, Q.D.#, Wedge, D.C.#, Van Loo, P.#, on behalf of the PCAWG Evolution and Heterogeneity Working Group and the PCAWG consortium (2021). Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. Cell, 184:2239-2254.
Tarabichi, M.#, Salcedo, A.#, Deshwar, A.G.#, Ni Leathlobhair, M.#, Wintersinger, J., Wedge, D.C.#, Van Loo, P.#, Morris, Q.D.#, Boutros, P.C.# (2021). A practical guide to cancer subclonal reconstruction from DNA sequencing. Nature Methods, 18:144-155. Review.
Minussi, D.C.#, Nicholson, M.D.#, Ye, H.#, Davis, A., Wang, K., Baker, T., Tarabichi, M., Sei, E., Du, H., Rabbani, M., Peng, C., Hu, M., Bai, S., Lin, Y., Schalck, A., Multani, A., Ma, J., McDonald, T.O., Casasent, A., Barrera, A., Chen, H., Lim, B., Arun, B., Meric-Bernstam, F., Van Loo, P., Michor, F.#, Navin, N.E.# (2021). Breast Tumors Maintain a Reservoir of Subclonal Diversity During Expansion. Nature, 592:302-308.
2020
Gerstung, M.#, Jolly, C.#, Leshchiner, I.#, Dentro, S.C.#, Gonzalez, S.#, Rosebrock, D., Mitchell, T.J., Rubanova, Y., Anur, P., Yu, K., Tarabichi, M., Deshwar, A., Wintersinger, J., Kleinheinz, K., Vázquez-García, I., Haase, K., Jerman, L., Sengupta, S., Macintyre, G., Malikic, S., Donmez, N., Livitz, D.G., Cmero, M., Demeulemeester, J., Schumacher, S., Fan, Y., Yao, X., Lee, J., Schlesner, M., Boutros, P.C., Bowtell, D.D., Zhu, H., Getz, G., Imielinski, M., Beroukhim, R., Sahinalp, S.C., Ji, Y., Peifer, M., Markowetz, F., Mustonen, V., Yuan, K., Wang, W., Morris, Q.D., PCAWG Evolution and Heterogeneity Working Group, Spellman, P.T.#, Wedge, D.C.#, Van Loo, P.#; PCAWG Consortium (2020). The evolutionary history of 2,658 cancers. Nature, 578:122-128.
ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium (2020). Pan-cancer analysis of whole genomes. Nature, 578:82-93.
Salcedo, A.#, Tarabichi, M.#, Espiritu, S.M.G.#, Deshwar, A.G.#, David, M., Wilson, N.M., Dentro, S., Wintersinger, J.A., Liu, L.Y., Ko, M., Sivanandan, S., Zhang, H., Zhu, K., Ou Yang, T.H., Chilton, J.M., Buchanan, A., Lalansingh, C.M., P'ng, C., Anghel, C.V., Umar, I., Lo, B., Zou, W., DREAM SMC-Het Participants, Simpson, J.T., Stuart, J.M., Anastassiou, D., Guan, Y., Ewing, A.D., Ellrott, K.#, Wedge, D.C.#, Morris, Q.D.#, Van Loo, P.#, Boutros, P.C.# (2020). A community effort to create standards for evaluating tumor subclonal reconstruction. Nature Biotechnology, 38:97-107.
Watkins, T.B.K.#, Lim, E.L.#, Petkovic, M., Elizalde, S., Birkbak, N.J., Wilson, G.A., Moore, D.A., Gronroos. E., Rowan, A., Dewhurst, S.M., Demeulemeester, J., Dentro, S.C., Horswell, S., Au, L., Haase, K., Escudero, M., Rosenthal, R., Al Bakir, M., Xu, H., Litchfield, K., Lu, W.T., Mourikis, T.P., Dietzen, M., Spain, L., Cresswell, G.D., Biswas, D., Lamy, P., Nordentoft, I., Harbst, K., Castro-Giner, F., Yates, L.R., Caramia, F., Jaulin, F., Vicier, C., Tomlinson, I.P.M., Brastianos, P.K., Cho, R.J., Bastian, B.C., Dyrskjot, L., Jonsson, G.B., Savas, P., Loi, S., Campbell, P.J., Andre, F., Luscombe, N.M., Steeghs, N., Tjan-Heijnen, V.C.G., Szallasi, Z., Turajlic, S., Jamal-Hanjani, M., Van Loo, P., Bakhoum, S.M., Schwarz, R.F.#, McGranahan, N.#, Swanton, C.# (2020). Pervasive chromosomal instability and karyotype order in tumour evolution. Nature, 587:126-132.
2019
Fittall, M.W., Van Loo, P. (2019). Translating insights into tumor evolution to clinical practice: promises and challenges. Genome Medicine, 11:20. Review.
Rosenthal, R., Cadieux, E.L.#, Salgado, R.#, Bakir, M.A.#, Moore, D.A.#, Hiley, C.T.#, Lund, T.#, Tanić, M., Reading, J.L., Joshi, K., Henry, J.Y., Ghorani, E., Wilson, G.A., Birkbak, N.J., Jamal-Hanjani, M., Veeriah, S., Szallasi, Z., Loi, S., Hellmann, M.D., Feber, A., Chain, B., Herrero, J., Quezada, S.A., Demeulemeester, J., Van Loo, P., Beck, S., McGranahan, N., Swanton, C.; TRACERx consortium. (2019). Neoantigen-directed immune escape in lung cancer evolution. Nature, 567:479-485.
Steele, C.D., Tarabichi, M., Oukrif, D., Webster, A.P., Ye, H., Fittall, M., Lombard, P., Martincorena, I., Tarpey, P.S., Collord, G., Haase, K., Strauss, S.J., Berisha, F., Vaikkinen, H., Dhami, P., Jansen, M., Behjati, S., Amary, M.F., Tirabosco, R., Feber, A., Campbell, P.J., Alexandrov, L.B., Van Loo, P., Flanagan, A.M., Pillay, N. (2019). Undifferentiated sarcomas develop through distinct evolutionary pathways. Cancer Cell, 35:441-456.e8.
2018
Tarabichi, M., Martincorena, I., Gerstung, M., Leroi, A.M., Markowetz, F., PCAWG Evolution and Heterogeneity Working Group, Spellman, P.T., Morris, Q.D., Lingjærde, O.C., Wedge, D.C., Van Loo, P. (2018). Neutral tumor evolution? Nature Genetics, 50:1630-1633. Correspondence.
Jolly, C., Van Loo, P. (2018). Timing somatic events in the evolution of cancer. Genome Biology, 19:95. Review.
Turajlic, S.#, Xu, H.#, Litchfield, K.#, Rowan, A.#, Horswell, S.#, Chambers, T.#, O'Brien, T.#, Lopez, J.I.#, Watkins, T.B.K., Nicol, D., Stares, M., Challacombe, B., Hazell, S., Chandra, A., Mitchell, T.J., Au, L., Eichler-Jonsson, C., Jabbar, F., Soultati, A., Chowdhury, S., Rudman, S., Lynch, J., Fernando, A., Stamp, G., Nye, E., Stewart, A., Xing, W., Smith, J.C., Escudero, M., Huffman, A., Matthews, N., Elgar, G., Phillimore, B., Costa, M., Begum, S., Ward, S., Salm, M., Boeing, S., Fisher, R., Spain, L., Navas, C., Grönroos, E., Hobor, S., Sharma, S., Aurangzeb, I., Lall, S., Polson, A., Varia, M., Horsfield, C., Fotiadis, N., Pickering, L., Schwarz, R.F., Silva, B., Herrero, J., Luscombe, N.M., Jamal-Hanjani, M., Rosenthal, R., Birkbak, N.J., Wilson, G.A., Pipek, O., Ribli, D., Krzystanek, M., Csabai, I., Szallasi, Z., Gore, M., McGranahan, N., Van Loo, P., Campbell, P., Larkin, J., Swanton, C.; TRACERx Renal Consortium (2018). Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal. Cell, 173:595-610.e11.
2017
McGranahan, N.#, Rosenthal, R.#, Hiley, C.T., Rowan, A.J., Watkins, T.B.K., Wilson, G.A., Birkbak, N.J., Veeriah, S., Van Loo, P., Herrero, J., Swanton, C.; TRACERx Consortium (2017). Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution. Cell, 171:1259-1271.e11.
Cheng, J.#, Demeulemeester, J.#, Wedge, D.C., Vollan, H.K.M., Pitt, J.J., Russnes, H.G., Pandey, B.P., Nilsen, G., Nord, S., Bignell, G.R., White, K.P., Børresen-Dale, A.L., Campbell, P.J., Kristensen, V.N., Stratton, M.R., Lingjærde, O.C., Moreau, Y., Van Loo, P. (2017). Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nature Communications, 8:1221.
Martincorena, I., Raine, K.M., Gerstung, M., Dawson, K.J., Haase, K., Van Loo, P., Davies, H., Stratton, M.R., Campbell, P.J. (2017). Universal Patterns of Selection in Cancer and Somatic Tissues. Cell, 171:1029-1041.e21.
Yates, L.R.#, Knappskog, S.#, Wedge, D., Farmery, J.H.R., Gonzalez, S., Martincorena, I., Alexandrov, L.B., Van Loo, P., Haugland, H.K., Lilleng, P.K., Gundem, G., Gerstung, M., Pappaemmanuil, E., Gazinska, P., Bhosle, S.G., Jones, D., Raine, K., Mudie, L., Latimer, C., Sawyer, E., Desmedt, C., Sotiriou, C., Stratton, M.R., Sieuwerts, A.M., Lynch, A.G., Martens, J.W., Richardson, A.L., Tutt, A., Lønning, P.E.#, Campbell, P.J.# (2017). Genomic Evolution of Breast Cancer Metastasis and Relapse. Cancer Cell, 32:169-184.e7.
Jamal-Hanjani, M.#, Wilson, G.A.#, McGranahan, N.#, Birkbak, N.J.#, Watkins, T.B.K.#, Veeriah, S.#, Shafi, S., Johnson, D.H., Mitter, R., Rosenthal, R., Salm, M., Horswell, S., Escudero, M., Matthews, N., Rowan, A., Chambers, T., Moore, D.A., Turajlic, S., Xu, H., Lee, S.M., Forster, M.D., Ahmad, T., Hiley, C.T., Abbosh, C., Falzon, M., Borg, E., Marafioti, T., Lawrence, D., Hayward, M., Kolvekar, S., Panagiotopoulos, N., Janes, S.M., Thakrar, R., Ahmed, A., Blackhall, F., Summers, Y., Shah, R., Joseph, L., Quinn, A.M., Crosbie, P.A., Naidu, B., Middleton, G., Langman, G., Trotter, S., Nicolson, M., Remmen, H., Kerr, K., Chetty, M., Gomersall, L., Fennell, D.A., Nakas, A., Rathinam, S., Anand, G., Khan, S., Russell, P., Ezhil, V., Ismail, B., Irvin-Sellers, M., Prakash, V., Lester, J.F., Kornaszewska, M., Attanoos, R., Adams, H., Davies, H., Dentro, S., Taniere, P., O'Sullivan, B., Lowe, H.L., Hartley, J.A., Iles, N., Bell, H., Ngai, Y., Shaw, J.A., Herrero, J., Szallasi, Z., Schwarz, R.F., Stewart, A., Quezada, S.A., Le Quesne, J., Van Loo, P., Dive, C., Hackshaw, A., Swanton, C.; TRACERx Consortium (2017). Tracking the Evolution of Non-Small-Cell Lung Cancer. New England Journal of Medicine, 376:2109-2121.
Dentro, S.C., Wedge, D.C., Van Loo, P. (2017). Principles of reconstructing the subclonal architecture of cancers. In Cancer Evolution (Cold Spring Harbor Laboratory Press). Swanton, C., Bardelli, A., Shah, S., Polyak, K., Graham, T. (eds.).
2016
Demeulemeester, J.#, Kumar, P.#, Møller, E.K.#, Nord, S., Wedge, D.C., Peterson, A., Mathiesen, R.R., Fjelldal, R., Zamani Esteki, M., Theunis, K., Fernandez Gallardo, E., Grundstad, A.J., Borgen, E., Baumbusch, L.O., Børresen-Dale, A.L., White, K.P.#, Kristensen, V.N.#, Van Loo, P.#, Voet, T.#, Naume, B.# (2016). Tracing the origin of disseminated tumor cells in breast cancer using single-cell sequencing. Genome Biology, 17:250.
Alexandrov, L.B., Ju, Y.S., Haase, K., Van Loo, P., Martincorena, I., Nik-Zainal, S., Totoki, Y., Fujimoto, A., Nakagawa, H., Shibata, T., Campbell, P.J., Vineis, P., Phillips, D.H., Stratton, M.R. (2016). Mutational signatures associated with tobacco smoking in human cancer. Science, 354:618-622.
2015
Martincorena, I., Roshan, A., Gerstung, M., Ellis, P., Van Loo, P., McLaren, S., Wedge, D.C., Fullam, A., Alexandrov, L.B., Tubio, J.M., Stebbings, L., Menzies, A., Widaa, S., Stratton, M.R., Jones, P.H., Campbell, P.J. (2015). High burden and pervasive positive selection of somatic mutations in normal human skin. Science, 348:880-886.
Gundem, G., Van Loo, P., Kremeyer, B., Alexandrov, L.B., Tubio, J.M.C., Papaemmanuil, E., Brewer, D.S., Kallio, H.M.L., Hӧgnäs, G., Annala, M., Kivinummi, K., Goody, V., Latimer, C., O’Meara, S., Dawson, K.J., Isaacs, W., Emmert-Buck, M.R., Nykter, M., Foster, C., Kote-Jarai, Z., Easton, D., Whitaker, H.C., ICGC Prostate UK Group, Neal, D.E., Cooper, C.S., Eeles, R.A., Visakorpi, T., Campbell, P.J., McDermott, U.#, Wedge, D.C.#, Bova, G.S.# (2015). The evolutionary history of lethal metastatic prostate cancer. Nature, 520:353-357.
Cooper, C.S.#, Eeles, R.#, Wedge, D.C.#, Van Loo, P.#, Gundem, G., Alexandrov, L.B., Kremeyer, B., Butler, A., Lynch, A.G., Camacho, N., Massie, C.E., Kay, J., Luxton, H.J., Edwards, S., Kote-Jarai, Z., Dennis, N., Merson, S., Leongamornlert, D., Zamora, J., Corbishley, C., Thomas, S., Nik-Zainal, S., Ramakrishna, M., O'Meara, S., Matthews, L., Clark, J., Hurst, R., Mithen, R., Bristow, R.G., Boutros, P.C., Fraser, M., Cooke, S., Raine, K., Jones, D., Menzies, A., Stebbings, L., Hinton, J., Teague, J., McLaren, S., Mudie, L., Hardy, C., Anderson, E., Joseph, O., Goody, V., Robinson, B., Maddison, M., Gamble, S., Greenman, C., Berney, D., Hazell, S., Livni, N.; the ICGC Prostate Group, Fisher, C., Ogden, C., Kumar, P., Thompson, A., Woodhouse, C., Nicol, D., Mayer, E., Dudderidge, T., Shah, N.C., Gnanapragasam, V., Voet, T., Campbell, P., Futreal, A., Easton, D., Warren, A.Y.#, Foster, C.S.#, Stratton, M.R., Whitaker, H.C.#, McDermott, U.#, Brewer, D.S.#, Neal, D.E.# (2015). Analysis of the genetic phylogeny of multifocal prostate cancer identifies multiple independent clonal expansions in neoplastic and morphologically normal prostate tissue. Nature Genetics, 47:367-372.
2014
Li, Y.#, Schwab, C.#, Ryan, S.L.#, Papaemmanuil, E., Robinson, H.M., Jacobs, P., Moorman, A.V., Dyer, S., Borrow, J., Griffiths, M., Heerema, N.A., Carroll, A.J., Talley, P., Bown, N., Telford, N., Ross, F.M., Gaunt, L., McNally, R.J., Young, B.D., Sinclair, P., Rand, V., Teixeira, M.R., Joseph, O., Robinson, B., Maddison, M., Dastugue, N., Vandenberghe, P., Haferlach, C., Stephens, P.J., Cheng, J., Van Loo, P., Stratton, M.R., Campbell, P.J.#, Harrison, C.J.# (2014). Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia. Nature, 508:98-102.
Van Loo, P., Voet, T. (2014). Single cell analysis of cancer genomes. Current Opinion in Genetics and Development, 24:82-91.
2012
Nik-Zainal, S.#, Van Loo, P.#, Wedge, D.C.#, Alexandrov, L.B., Greenman, C.D., Lau, K.W., Raine, K., Jones, D., Marshall, J., Ramakrishna, M., Shlien, A., Cooke, S.L., Hinton, J., Menzies, A., Stebbings, L.A., Leroy, C., Jia, M., Rance, R., Mudie, L.J., Gamble, S.J., Stephens, P.J., McLaren, S., Tarpey, P.S., Papaemmanuil, E., Davies, H.R., Varela, I., McBride, D.J., Bignell, G.R., Leung, K., Butler, A.P., Teague, J.W., Martin, S., Jönsson, G., Mariani, O., Boyault, S., Miron, P., Fatima, A., Langerød, A., Aparicio, S.A.J.R., Tutt, A., Sieuwerts, A.M., Borg, Å., Thomas, G., Salomon, A.V., Richardson, A.L., Børresen-Dale, A.-L., Futreal, P.A., Stratton, M.R., Campbell, P.J.; for the Breast Cancer Working Group of the International Cancer Genome Consortium (2012). The life history of 21 breast cancers. Cell, 149:994-1007.
Stephens, P.J.#, Tarpey, P.S.#, Davies, H., Van Loo, P., Greenman, C., Wedge, D.C., Nik-Zainal, S., Martin, S., Varela, I., Bignell, G.R., Yates, L.R., Papaemmanuil, E., Beare, D., Butler, A., Cheverton, A., Gamble, J., Hinton, J., Jia, M., Jayakumar, A., Jones, D., Latimer, C., Lau, K.W., McLaren, S., McBride, D.J., Menzies, A., Mudie, L., Raine, K., Rad, R., Chapman, M.S., Teague, J., Easton, D., Langerød, A., Oslo Breast Cancer Consortium (OSBREAC), Lee, M.T., Shen, C.Y., Tee, B.T., Huimin, B.W., Broeks, A., Vargas, A.C., Turashvili, G., Martens, J., Fatima, A., Miron, P., Chin, S.F., Thomas, G., Boyault, S., Mariani, O., Lakhani, S.R., van de Vijver, M., van 't Veer, L., Foekens, J., Desmedt, C., Sotiriou, C., Tutt, A., Caldas, C., Reis-Filho, J.S., Aparicio, S.A.J.R., Salomon, A.V., Børresen-Dale, A.-L., Richardson, A.L., Campbell, P.J., Futreal, P.A., Stratton, M.R. (2012). The landscape of cancer genes and mutational processes in breast cancer. Nature, 486:400-404.
2010
Van Loo, P.#, Nordgard, S.H.#, Lingjærde, O.C., Russnes, H.G., Rye, I.H., Sun, W., Weigman, V.J., Marynen P., Zetterberg, A., Naume, B., Perou, C.M., Børresen-Dale, A.-L.#, Kristensen, V.N.# (2010). Allele-specific copy number analysis of tumors. Proceedings of the National Academy of Sciences of the United States of America, 107:16910-16915.