Palaniraja Thandapani, Ph.D.
Areas of Research
- RNA Biology
- Gene Expression
- CRISPR Screens
Welcome to the Thandapani lab! Our lab studies mechanisms governing plasticity of mRNA translation during tumorigenesis, specifically how deregulation of transfer RNA (tRNA) pathways favor codon-biased translation of oncogenic programs in leukemias.
The overarching goals of our research program
We aim to understand (i) the full extent of tRNA expression, modifications and aminoacylation changes during normal hematopoiesis and in acute leukemias, (ii) mechanisms regulating these changes in normal versus disease states and (iii) how cells integrate this information to rewire translation and acquire phenotypic plasticity.
Join Our Lab
Individuals with a Ph.D. in cancer biology, molecular biology, biochemistry, genetics, immunology or a related field with a track record of publications/preprints are encouraged to apply for a postdoctoral fellow position. Candidates, particularly senior graduate students, interested in the projects outlined should apply with a CV, career objectives, and names of three references.