Singh Laboratory
Harjeet Singh, Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Singh Laboratory
Areas of Research
- Acute Myeloid Leukemia
- Adoptive Cell Therapy
- Bone Cancer
- CAR T-cells
- Immunology
- Immunotherapy
- Leukemia
- Lymphoma
- Targeted Therapy
Our translational research laboratory develops next-generation immune cell therapies for hematologic malignancies and solid tumors. Immunotherapy has transformed cancer treatment by harnessing the body’s own immune system and applying insights from its biology to develop powerful, personalized cell-based therapies. Our laboratory combines immune cell engineering, genetic modification and preclinical modeling — including chimeric antigen receptor (CAR) and T cell receptor (TCR) platforms, tumor infiltrating lymphocytes (TILs) and single-cell analyses — to accelerate clinical translation and improve antitumor efficacy.
Our Research Projects
Our current projects include:
- Developing immune cells — T cells, natural killer (NK) cells, T cell receptor (TCR) gdT cells — for immunotherapy
- Designing chimeric antigen receptors (CARs) to achieve a fully competent T cell activation signal for efficient efficacy
- Genetic modification and ex vivo expansion of CAR T cells using viral and non-viral methods (Sleeping Beauty system)
- Developing cytokine co-stimulation by expressing membrane bound form of cytokines on T cells
- Establishing efficacy of genetically modified immune cells in mouse models
- Neo-antigen and TCR identification for solid tumors
- Isolation and characterization of tumor infiltrating lymphocytes (TILs) for various solid tumors
- Single cell analysis of immune cells evaluating motility, killing and gene expression analysis
Contact Us
Principal Investigator
Harjeet Singh, Ph.D.
Assistant Professor, Pediatrics Research
Email: HSingh@MDAnderson.org
Phone: 713-745-0642
Office Location
Modular Labs (MOD1.021a)
7777 Knight Road
Houston, TX 77054
Mailing Address
MD Anderson Cancer Center
Pediatrics - Research
1515 Holcombe Blvd.
Unit 0853
Houston, TX 77030-4009
Harjeet Singh, Ph.D., Assistant Professor (left), Fiorela Hernandez, M.D., Clinical Assistant Professor (middle), Simon Olivares, B.S., Research Laboratory Coordinator (right)