- Departments, Labs and Institutes
- Shukla Laboratory
Areas of Research
- Immunotherapy Research
- Artificial Intelligence
- Acute Myeloid Leukemia Research
- Lymphoma Research
- Colorectal Cancer Research
- Cancer Genomics
- Single-Cell Genomics Research
- Melanoma Research
- Gastrointestinal Cancer Research
- Kidney Cancer Research
- Computational Biology Research
The Shukla lab is a highly translational group focused on antigen discovery and development of personalized immunotherapies.
We develop computational approaches and harness state-of-the-art bulk and single-cell sequencing technologies and experimental assays to identify the full complement of tumor antigens in patient samples, and their cognate T-cell receptors. We are creating the next generation of personalized cancer vaccines designed to target antigens identified within each patient. These novel vaccination approaches will be tested in clinical trials across multiple tumor types.We are building pipelines and machine learning models for integrated multi-omic analysis in order to elucidate mechanisms governing immunogenicity, immune escape and clinical outcomes to cancer immunotherapy. We are also establishing a comprehensive computational toolkit for characterization of highly polymorphic immune system-related genes which will significantly enable fundamental and translational research in tumor immunology.
The New York Times
After Giving Up on Cancer Vaccines, Doctors Start to Find Hope
October 10, 2022
Sachet A. Shukla, Ph.D., M.S.
Department of Hematopoietic Biology and Malignancy
Department of Immunology
7435 Fannin Street - 2SCR2.2022
Houston, TX, 77054