Areas of Research
- Breast Cancer
- Chemical Inhibitors
- Critical Care
- Host-Pathogen Interactions
- Infectious Disease
The research focus of Sharma Lab is innate immune responses in acute and chronic disease conditions. Specifically, the research group is engaged in understanding the myeloid cell generation, turnover and effector functions in regulation of inflammation in pneumonic and oncologic sepsis, chronic granulomatous disease (CGD) and breast cancer. We are conducting highly translational and clinical research using genetically engineered mouse models and patient samples aimed at diagnostic and therapeutic targeting of neutrophil and macrophage responses in these disease conditions.
- Glycolipid Metabolite β-Glucosylceramide Is a Neutrophil Extracellular Trap-Inducing Ligand of Mincle Released during Bacterial Infection and Inflammation. Sharma A, Chauhan A, Chauhan P, Evans DL, Szlabick RE, Aaland MO, Mishra BB, Sharma J.J Immunol. 2022 Jul 15;209(2):391-400. doi: 10.4049/jimmunol.2100855. Epub 2022 Jun 29.PMID: 35768151
- Sharma A, Mccann, K., Tripathi JK, Chauhan P, Zerbe C, Mishra BB, Holland SM, Sharma J. 2019. Tamoxifen restores extracellular trap formation in neutrophils from patients of chronic granulomatous disease, in ROS-independent manner. J Allergy Clin Immunol. 2019 Apr 27.
- Jondle, C.N., Gupta, K; Mishra, BB, Sharma, J. 2018. Klebsiella pneumoniae infection of neutrophils inhibits their efferocytic clearance by modulating phosphatidylserine exposure and cell death pathway. PLoS Pathogens. 2018 Oct 1;14(10):e1007338. doi: 10.1371/journal.ppat.1007338. eCollection 2018 Oct.
- Chauhan A, Sun Y, Sukumaran P, Quenum Zangbede FO, Jondle CN, Sharma A, Evans DL, Chauhan P, Szlabick RE, Aaland MO, Birnbaumer L, Sharma J, Singh BB, Mishra BB. M1 Macrophage Polarization Is Dependent on TRPC1-Mediated Calcium Entry. iScience. 2018 Oct 26;8:85-102. doi: 10.1016/j.isci.2018.09.014. Epub 2018 Sep 20. PubMed PMID: 30293012; PubMed Central PMCID: PMC6174824.
Join Our Lab
Lab is currently accepting graduate students
Title: Neutrophil Extracellular Traps and Host Immunity
Funding Source: NIH/NIAID
This project aims to elucidate the molecular mechanism of neutrophil extracellular trap formationn to harness its therapeutic potential for restoring antimicrobial capacity of neutrophils in NOX2 independent manner.
Title: Lung Macrophage Memory Development and Responses in Secondary Pneumonia and Sepsis
Funding Source: NIH/NIAID
Title: Correlation of circulating NETs and cell-free DNA with inflammatory immune responses in cancer patients with sepsis
Funding Source: VolitionRX