Critical Care Medicine
Karen Chen, M.D.
Professor and chair ad interim
- Departments, Labs and Institutes
- Departments and Divisions
- Critical Care
The Critical Care Medicine department was organized in 1997 to develop a unified, multidisciplinary approach to critical care in our 52-bed, state-of-the-art, Intensive Care Unit.
Critically ill medical and surgical patients are managed by a multidisciplinary team of board-certified intensivists trained in the fields of anesthesiology, pulmonary medicine and surgery, critical care fellows, anesthesiology house staff, mid-level providers, critical care nurses, respiratory care practitioners, pharmacists, nutritionists, physical therapists, ethicists, social workers and members of the clergy. Our team works side by side with the primary oncology teams to treat the life-threatening complications that sometimes arise during a cancer patient’s treatment.
Research
The department's research mission is to facilitate oncology studies at MD Anderson. Research in the department typically involves identifying problems from clinical observational studies and quality improvement initiatives and testing potential solutions in the lab and through clinical trials. These efforts include:
- Describing patterns of medical and surgical critical illness specific to the cancer population and predicting outcomes in the ICU
- Finding new ways to predict patients at greatest risk of treatment toxicity
- Developing techniques for organ function preservation to allow patients to tolerate increasingly toxic cancer treatments
- Providing expert physiological measurements to collaborators as they measure the efficacy of their own novel treatments
Please see the Critical Care Medicine research page for more information.
Related Departments & Divisions
FY25 Department Accomplishments
Clinical
- Patio for ICU Patients & Families: Located on the west side of the Main Building, this first-of-its-kind initiative at MD Anderson was led by Dr. Nisha Rathi, Joseph McCarty, PT, and Tina Watkins, OT. The space was repurposed into a dedicated outdoor space for patients in the Intensive Care Unit (ICU). A safety algorithm, developed by the interdisciplinary team, identifies which patients may go outdoors.
- ICU Liberation Bundle: A total of 120 participants, including physicians, APPs, nurses, pharmacists, RTs, and PTs/Ots, have completed the SCCM ICU Liberation course hosted by the Department of Critical Care Medicine. This course incorporates recommendations from the pain, agitation/sedation, delirium, immobility, and sleep disruption guidelines and provides implementation strategies through the ICU Liberation Bundle (A-F). In FY25 the ICU Liberation Bundle initiative became an institutional QAPI Structural PFA. We operationalized EPIC Dashboards, EPIC tools, made EPIC process and order changes, and began process improvement initiatives to improve bundle component and overall bundle compliance.
- Advanced Support Unit (ASU): 160 patients were admitted to the ASU in FY2025, which improved the Vizient efficiency metric for ICU utilization in the last 2 days of life.
Education
- Joseph Nates, M.D., has advanced the global reach of oncologic and critical care medicine through leadership, education, and international collaboration. As President of the Global Society of Oncologic Critical Care (GSOCC), he oversaw the society’s second international congress and secured its membership in the World Federation of Intensive Care Societies. In addition to Dr. Nates, MD Anderson faculty Olakunle Idowu, M.D., Dereddi Raja Reddy, M.D., and Dilip Thakar, M.D., also presented at the GSOCC conference in Panama in 2025. He also played a central role in expanding partnerships with the Iberic and PanAmerican Federation of Critical Care Societies, which represent 25 countries, and collaborated with the Spanish Society of Critical Care to host the first Oncologic Critical Care Symposium in Seville, Spain. In addition to Dr. Nates, MD Anderson faculty Karen Chen, M.D., Philip Thakar, M.D. and Dereddi Raja Reddy, M.D., also presented at the conference. His efforts in launching multilingual education, including the Third World Symposium of Critical Care, which is offered in both English and Spanish, continue to remove barriers and broaden access to critical care knowledge worldwide—positioning MD Anderson as a leader in shaping the future of oncologic critical care. In addition to his leadership, Dr. Nates has contributed to advancing standards of care through scholarship, teaching, and global health initiatives. He has collaborated with leading international groups, including Nine i/GRRR-OH and Tecno-Sepsis, where he was recognized in Dubai for his innovations in sepsis management. His work with the Pan American Health Organization and World Health Organization has helped shape sepsis training for developing countries, and his leadership on guideline task forces has informed critical policies on resource allocation, sedation, analgesia, and delirium management in intensive care units. Through these achievements, Dr. Nates has elevated MD Anderson’s Department of Critical Care as a global authority in oncologic critical care, extending the institution’s impact far beyond its campus and advancing its mission worldwide.
Research
- Activated a US multicenter prospective trial, “Association of lymphopenia on outcomes of septic cancer patients admitted to the ICU.”
- Received grant funding for two ongoing randomized/multicenter trials.
- Multicenter clinical trial of IL-7 and COVID-19, JCI.
- Septic shock in the immunocompromised cancer patient: a narrative review. Critical Care with Nine-I Investigators.
- Cytokine Storms in COVID-19, HLH and CAR-T Therapy, JAMA Netw Open.
- Presented many Abstracts at National and International Meetings.
Contact Us
Critical Care
1515 Holcombe Blvd., Unit 112
Room B7.4320
Houston, Texas 77030
Phone: 713-792-5040
Fax: 713-792-0488
Critical Care Fellowship
request an appointment online.