Publications
Lucchetti D, Colella F, d'Amati A, Servidei T, Gessi M, Chiara P, Cellini B, Toma F, Giacò L, Persiani F, Perelli L, Mantini G, Genovese G, Masetto I, Ruggiero A, Sgambato A. Spatial Analysis Identifies CD147 as a Novel Marker of High-Grade Childhood Posterior Fossa Ependymoma. Lab Invest. 2025 Jul;105(7):104175. doi: 10.1016/j.labinv.2025.104175. Epub 2025 Apr 16. PMID: 40250710.
Perelli L, Genovese G. Switching on the evolutionary potential of pancreatic cancer: the tumor suppressor functions of PBRM1. J Clin Invest. 2025 Jun 2;135(11):e193205. doi: 10.1172/JCI193205. PMID: 40454477; PMCID: PMC12126216.
Perelli L, Zhang L, Mangiameli S, Giannese F, Mahadevan KK, Peng F, Citron F, Khan H, Le C, Gurreri E, Carbone F, Russell AJC, Soeung M, Lam TNA, Lundgren S, Marisetty S, Zhu C, Catania D, Mohamed AMT, Feng N, Augustine JJ, Sgambato A, Tortora G, Draetta GF, Tonon G, Futreal A, Giuliani V, Carugo A, Viale A, Kim MP, Heffernan TP, Wang L, Kalluri R, Cittaro D, Chen F, Genovese G. Evolutionary fingerprints of epithelial-to-mesenchymal transition. Nature. 2025 Apr;640(8060):1083-1092. doi: 10.1038/s41586-025-08671-2. Epub 2025 Mar 5. PMID: 40044861.
Colella F, Calapà F, Artemi G, Pazzaglia E, Colonna R, Vitale S, Lazzarino G, Vincenzoni F, Fiori ME, De Maria R, Lucchisani S, Genovese G, Perelli L, Tavazzi B, Sgambato A, Lucchetti D. CD147 Mediates the Metabolic Reprogramming of Cancer Associated Fibroblasts Induced by EVs Released by Differentiating Cancer Stem Cells. J Extracell Biol. 2025 Mar 17;4(3):e70039. doi: 10.1002/jex2.70039. PMID: 40104175; PMCID: PMC11913892.
Citron F, Ho IL, Balestrieri C, Liu Z, Yen EN, Cecchetto L, Perelli L, Zhang L, Castillo Montanez LA, Blazanin N, Dyke CA, Shah R, Attanasio S, Srinivasan S, Chen KC, Chen Z, Scognamiglio I, Pham N, Khan H, Jiang S, Pan J, Vanderkruk B, Leung C, Mattohti M, Rai K, Chu Y, Wang L, Gao S, Deem AK, Carugo A, Wang H, Yao W, Tonon G, Xiong Y, Lorenzi PL, Bonini C, Zal A, Hoffman B, Giuliani V, Heffernan T, Jeter CR, Lissanu Y, Genovese G, Di Pilato M, Viale A, Draetta GF. WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer. bioRxiv [Preprint]. 2025 Jan 2:2024.10.21.619543. doi: 10.1101/2024.10.21.619543. PMID: 39484624; PMCID: PMC11526913.
Firsanov D, Zacher M, Tian X, Sformo TL, Zhao Y, Tombline G, Lu JY, Zheng Z, Perelli L, Gurreri E, Zhang L, Guo J, Korotkov A, Volobaev V, Biashad SA, Zhang Z, Heid J, Maslov A, Sun S, Wu Z, Gigas J, Hillpot E, Martinez J, Lee M, Williams A, Gilman A, Hamilton N, Haseljic E, Patel A, Straight M, Miller N, Ablaeva J, Tam LM, Couderc C, Hoopman M, Moritz R, Fujii S, Hayman DJ, Liu H, Cai Y, Leung AKL, Simons MJP, Zhang Z, Nelson CB, Abegglen LM, Schiffman JD, Gladyshev VN, Modesti M, Genovese G, Vijg J, Seluanov A, Gorbunova V. DNA repair and anti-cancer mechanisms in the long-lived bowhead whale. bioRxiv [Preprint]. 2024 Nov 5:2023.05.07.539748. doi: 10.1101/2023.05.07.539748. PMID: 39574710; PMCID: PMC11580846.
Perelli L, Genovese G, Draetta GF. The KRAS mutational spectrum and its clinical implications in pancreatic cancer. Cancer Cell. 2024 Sep 9;42(9):1494-1496. doi: 10.1016/j.ccell.2024.08.001. Epub 2024 Aug 29. PMID: 39214093.
Bezwada D, Perelli L, Lesner NP, Cai L, Brooks B, Wu Z, Vu HS, Sondhi V, Cassidy DL, Kasitinon S, Kelekar S, Cai F, Aurora AB, Patrick M, Leach A, Ghandour R, Zhang Y, Do D, McDaniel P, Sudderth J, Dumesnil D, House S, Rosales T, Poole AM, Lotan Y, Woldu S, Bagrodia A, Meng X, Cadeddu JA, Mishra P, Garcia-Bermudez J, Pedrosa I, Kapur P, Courtney KD, Malloy CR, Genovese G, Margulis V, DeBerardinis RJ. Mitochondrial complex I promotes kidney cancer metastasis. Nature. 2024 Sep;633(8031):923-931. doi: 10.1038/s41586-024-07812-3. Epub 2024 Aug 14. PMID: 39143213; PMCID: PMC11424252.
Perelli L, Zhang L, Mangiameli S, Russell AJC, Giannese F, Peng F, Carbone F, Le C, Khan H, Citron F, Soeung M, Lam TNA, Lundgren S, Zhu C, Catania D, Feng N, Gurreri E, Sgambato A, Tortora G, Draetta GF, Tonon G, Futreal A, Giuliani V, Carugo A, Viale A, Heffernan TP, Wang L, Cittaro D, Chen F, Genovese G. Evolutionary fingerprints of EMT in pancreatic cancers. bioRxiv [Preprint]. 2023 Sep 19:2023.09.18.558231. doi: 10.1101/2023.09.18.558231. PMID: 37786705; PMCID: PMC10541589.
Perelli L, Carbone F, Zhang L, Huang JK, Le C, Khan H, Citron F, Del Poggetto E, Gutschner T, Tomihara H, Soeung M, Minelli R, Srinivasan S, Peoples M, Lam TNA, Lundgren S, Xia R, Zhu C, Mohamed AMT, Zhang J, Sircar K, Sgambato A, Gao J, Jonasch E, Draetta GF, Futreal A, Bakouny Z, Van Allen EM, Choueiri T, Signoretti S, Msaouel P, Litchfield K, Turajlic S, Wang L, Chen YB, Di Natale RG, Hakimi AA, Giuliani V, Heffernan TP, Viale A, Bristow CA, Tannir NM, Carugo A, Genovese G. Interferon signaling promotes tolerance to chromosomal instability during metastatic evolution in renal cancer. Nat Cancer. 2023 Jul;4(7):984-1000. doi: 10.1038/s43018-023-00584-1. Epub 2023 Jun 26. PMID: 37365326; PMCID: PMC10368532.
Gurreri E, Genovese G, Perelli L, Agostini A, Piro G, Carbone C, Tortora G. KRAS-Dependency in Pancreatic Ductal Adenocarcinoma: Mechanisms of Escaping in Resistance to KRAS Inhibitors and Perspectives of Therapy. Int J Mol Sci. 2023 May 26;24(11):9313. doi: 10.3390/ijms24119313. PMID: 37298264; PMCID: PMC10253344.
Soeung M, Perelli L, Chen Z, Dondossola E, Ho IL, Carbone F, Zhang L, Khan H, Le CN, Zhu C, Peoples MD, Feng N, Jiang S, Zacharias NM, Minelli R, Shapiro DD, Deem AK, Gao S, Cheng EH, Lucchetti D, Walker CL, Carugo A, Giuliani V, Heffernan TP, Viale A, Tannir NM, Draetta GF, Msaouel P, Genovese G. SMARCB1 regulates the hypoxic stress response in sickle cell trait. Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2209639120. doi: 10.1073/pnas.2209639120. Epub 2023 May 15. PMID: 37186844; PMCID: PMC10214195.
Shapiro DD, Zacharias NM, Tripathi DN, Karki M, Bertocchio JP, Soeung M, He R, Westerman ME, Gao J, Rao P, Lam TNA, Jonasch E, Perelli L, Cheng EH, Carugo A, Heffernan TP, Walker CL, Genovese G, Tannir NM, Karam JA, Msaouel P. Neddylation inhibition sensitises renal medullary carcinoma tumours to platinum chemotherapy. Clin Transl Med. 2023 May;13(5):e1267. doi: 10.1002/ctm2.1267. PMID: 37226898; PMCID: PMC10210052.
Shapiro DD, Soeung M, Perelli L, Dondossola E, Surasi DS, Tripathi DN, Bertocchio JP, Carbone F, Starbuck MW, Van Alstine ML, Rao P, Katz MHG, Parker NH, Shah AY, Carugo A, Heffernan TP, Schadler KL, Logothetis C, Walker CL, Wood CG, Karam JA, Draetta GF, Tannir NM, Genovese G, Msaouel P. Association of High-Intensity Exercise with Renal Medullary Carcinoma in Individuals with Sickle Cell Trait: Clinical Observations and Experimental Animal Studies. Cancers (Basel). 2021 Nov 30;13(23):6022. doi: 10.3390/cancers13236022. PMID: 34885132; PMCID: PMC8656882.
Lucchetti D, Santini G, Perelli L, Ricciardi-Tenore C, Colella F, Mores N, Macis G, Bush A, Sgambato A, Montuschi P. Detection and characterisation of extracellular vesicles in exhaled breath condensate and sputum of COPD and severe asthma patients. Eur Respir J. 2021 Aug 5;58(2):2003024. doi: 10.1183/13993003.03024-2020. PMID: 33795323.
Tomihara H, Carbone F, Perelli L, Huang JK, Soeung M, Rose JL, Robinson FS, Lissanu Deribe Y, Feng N, Takeda M, Inoue A, Poggetto ED, Deem AK, Maitra A, Msaouel P, Tannir NM, Draetta GF, Viale A, Heffernan TP, Bristow CA, Carugo A, Genovese G. Loss of ARID1A Promotes Epithelial-Mesenchymal Transition and Sensitizes Pancreatic Tumors to Proteotoxic Stress. Cancer Res. 2021 Jan 15;81(2):332-343. doi: 10.1158/0008-5472.CAN-19-3922. Epub 2020 Nov 6. PMID: 33158812; PMCID: PMC8728103.
Citron F, Perelli L, Deem AK, Genovese G, Viale A. Leukotrienes, a potential target for Covid-19. Prostaglandins Leukot Essent Fatty Acids. 2020 Oct;161:102174. doi: 10.1016/j.plefa.2020.102174. Epub 2020 Sep 17. PMID: 32977289; PMCID: PMC7495247.
Lucchetti D, Battaglia A, Ricciardi-Tenore C, Colella F, Perelli L, De Maria R, Scambia G, Sgambato A, Fattorossi A. Measuring Extracellular Vesicles by Conventional Flow Cytometry: Dream or Reality? Int J Mol Sci. 2020 Aug 29;21(17):6257. doi: 10.3390/ijms21176257. PMID: 32872424; PMCID: PMC7503575.
Lucchetti D, Perelli L, Colella F, Ricciardi-Tenore C, Scoarughi GL, Barbato G, Boninsegna A, De Maria R, Sgambato A. Low-intensity pulsed ultrasound affects growth, differentiation, migration, and epithelial-to-mesenchymal transition of colorectal cancer cells. J Cell Physiol. 2020 Jun;235(6):5363-5377. doi: 10.1002/jcp.29423. Epub 2020 Jan 22. PMID: 31967331.
Msaouel P, Malouf GG, Su X, Yao H, Tripathi DN, Soeung M, Gao J, Rao P, Coarfa C, Creighton CJ, Bertocchio JP, Kunnimalaiyaan S, Multani AS, Blando J, He R, Shapiro DD, Perelli L, Srinivasan S, Carbone F, Pilié PG, Karki M, Seervai RNH, Vokshi BH, Lopez-Terrada D, Cheng EH, Tang X, Lu W, Wistuba II, Thompson TC, Davidson I, Giuliani V, Schlacher K, Carugo A, Heffernan TP, Sharma P, Karam JA, Wood CG, Walker CL, Genovese G, Tannir NM. Comprehensive Molecular Characterization Identifies Distinct Genomic and Immune Hallmarks of Renal Medullary Carcinoma. Cancer Cell. 2020 May 11;37(5):720-734.e13. doi: 10.1016/j.ccell.2020.04.002. Epub 2020 Apr 30. PMID: 32359397; PMCID: PMC7288373.
Lucchetti D, Colella F, Perelli L, Ricciardi-Tenore C, Calapà F, Fiori ME, Carbone F, De Maria R, Sgambato A. CD147 Promotes Cell Small Extracellular Vesicles Release during Colon Cancer Stem Cells Differentiation and Triggers Cellular Changes in Recipient Cells. Cancers (Basel). 2020 Jan 21;12(2):260. doi: 10.3390/cancers12020260. PMID: 31973205; PMCID: PMC7072373.