The research in Moghaddam Laboratory focuses on airway inflammation and its role in airway epithelial tumorigenesis. Cigarette smoking is the principal cause of lung cancer. However, several studies have found that smokers with chronic obstructive pulmonary disease (COPD), an inflammatory disease of the lung, have an increased risk of lung cancer compared to smokers with comparable cigarette exposure but without COPD.
Importantly, among smokers with COPD, even following smoke cessation, inflammation persists as does the increased risk of lung cancer. These facts suggest a strong link between COPD-related airway inflammation and lung cancer which is being studied and mechanistically dissected in Moghaddam Laboratory.