Ludwig Laboratory
Joseph Ludwig, M.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Ludwig Laboratory
Areas of Research
- Osteosarcoma
- Ewing Sarcoma
- Single-Cell Genomics
- Tumor Microenvironment
The Ludwig Lab studies sarcoma across the continuum of basic discovery, translational research and clinical investigation. Our research seeks to understand how fusion oncogenes, lineage plasticity and the tumor microenvironment govern tumor evolution, metastasis and treatment resistance. By combining single-cell and spatial omics, bioengineering, functional genomics and advanced computational approaches, we identify new therapeutic vulnerabilities in rare cancers. We collaborate closely with clinicians and industry partners to translate these discoveries into innovative therapies, including strategies targeting the IGF1/PI3K/mTOR pathway. Looking forward, we are building multimodal AI-driven digital twins that integrate genomic, spatial, radiologic and clinical data to guide precision treatment and improve outcomes for patients with sarcoma.
Our Research
Our research is multidisciplinary and ranges from basic science to translational work.
Select Publications
Truong DD, Weistuch C, Murgas KA, Admane P, King BL, Chauviere Lee J, Lamhamedi-Cherradi SE, Swaminathan J, Daw NC, Gordon N, Gopalakrishnan V, Gorlick RG, Somaiah N, Deasy JO, Mikos AG, Tannenbaum A, Ludwig J. Mapping the Single-Cell Differentiation Landscape of Osteosarcoma. Clin Cancer Res. 2024 Aug 1;30(15):3259-3272. doi: 10.1158/1078-0432.CCR-24-0563. PMID: 38775859; PMCID: PMC11293971.
Lamhamedi-Cherradi SE, Maitituoheti M, Menegaz BA, Krishnan S, Vetter AM, Camacho P, Wu CC, Beird HC, Porter RW, Ingram DR, Ramamoorthy V, Mohiuddin S, McCall D, Truong DD, Cuglievan B, Futreal PA, Velasco AR, Anvar NE, Utama B, Titus M, Lazar AJ, Wang WL, Rodriguez-Aguayo C, Ratan R, Livingston JA, Rai K, MacLeod AR, Daw NC, Hayes-Jordan A, Ludwig JA. The androgen receptor is a therapeutic target in desmoplastic small round cell sarcoma. Nat Commun. 2022 Jun 1;13(1):3057. doi: 10.1038/s41467-022-30710-z. PMID: 35650195; PMCID: PMC9160255.
Truong DD, Lamhamedi-Cherradi SE, Porter RW, Krishnan S, Swaminathan J, Gibson A, Lazar AJ, Livingston JA, Gopalakrishnan V, Gordon N, Daw NC, Navin NE, Gorlick R, Ludwig JA. Dissociation protocols used for sarcoma tissues bias the transcriptome observed in single-cell and single-nucleus RNA sequencing. BMC Cancer. 2023 May 31;23(1):488. doi: 10.1186/s12885-023-10977-1. PMID: 37254069; PMCID: PMC10230784.
Wu CC, Beird HC, Lamhamedi-Cherradi SE, Soeung M, Ingram D, Truong DD, Porter RW, Krishnan S, Little L, Gumbs C, Zhang J, Titus M, Genovese G, Ludwig JA, Lazar AJ, Hayes-Jordan A, Futreal PA. Multi-site desmoplastic small round cell tumors are genetically related and immune-cold. NPJ Precis Oncol. 2022 Apr 4;6(1):21. doi: 10.1038/s41698-022-00257-9. PMID: 35379887; PMCID: PMC8980094.
Lamhamedi-Cherradi SE, Mohiuddin S, Mishra DK, Krishnan S, Velasco AR, Vetter AM, Pence K, McCall D, Truong DD, Cuglievan B, Menegaz BA, Utama B, Daw NC, Molina ER, Zielinski RJ, Livingston JA, Gorlick R, Mikos AG, Kim MP, Ludwig JA. Transcriptional activators YAP/TAZ and AXL orchestrate dedifferentiation, cell fate, and metastasis in human osteosarcoma. Cancer Gene Ther. 2021 Dec;28(12):1325-1338. doi: 10.1038/s41417-020-00281-6. Epub 2021 Jan 6. PMID: 33408328; PMCID: PMC8636268.
Contact Us
Principal Investigator
Joseph Ludwig, M.D.
Professor, Sarcoma Medical Oncology
JALudwig@MDAnderson.org
Mailing Address
UT MD Anderson
Sarcoma Medical Oncology
1515 Holcombe Blvd.
Unit 1952
Houston, TX 77030-4009
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Research Areas
Find out about the four types of research taking place at UT MD Anderson.