Kalluri Lab Publications
2024
Zhou X, LeBleu VS, Fletcher-Sananikone E, Kim J, Dai J, Li B, Wu CC, Sugimoto H, Miyake T, Becker LM, Volpert OV, Lawson E, Espinosa Da Silva C, Patel SI, Kizu A, Ehsanipour EA, Sha D, Karam JA, McAndrews KM, Kalluri R. Vascular heterogeneity of tight junction Claudins guides organotropic metastasis. Nat Cancer. 2024 Sep;5(9):1371-1389. doi:10.1038/s43018-024-00813-1. Epub 2024 Sep 17. PMID: 39289595.
Kapoor KS, Harris K, Arian KA, Ma L, Schueng Zancanela B, Church KA, McAndrews KM, Kalluri R. High throughput and rapid isolation of extracellular vesicles and exosomes with purity using size exclusion liquid chromatography. Bioact Mater. 2024 Sep 4;40:683-695. doi:10.1016/j.bioactmat.2024.08.002. PMID: 39290685; PMCID: PMC11407901.
Luo X, McAndrews KM, Arian KA, Morse SJ, Boeker V, Kumbhar SV, Hu Y, Mahadevan KK, Church KA, Chitta S, Ryujin NT, Hensel J, Dai J, Dowlatshahi DP, Sugimoto H, Kirtley ML, LeBleu VS, Shalapour S, Simmons JH, Kalluri R. Development of an engineered extracellular vesicles-based vaccine platform for combined delivery of mRNA and protein to induce functional immunity. J Control Release. 2024 Oct;374:550-562. doi:10.1016/j.jconrel.2024.08.017. Epub 2024 Aug 30. PMID: 39146981.
Kalluri R. The biology and function of extracellular vesicles in immune response and immunity. Immunity. 2024 Aug 13;57(8):1752-1768. doi:10.1016/j.immuni.2024.07.009. PMID: 39142276; PMCID: PMC11401063.
Mahadevan KK, Dyevoich AM, Chen Y, Li B, Sugimoto H, Sockwell AM, McAndrews KM, Sthanam LK, Wang H, Shalapour S, Watowich SS, Kalluri R. Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer. Science. 2024 Jun 28;384(6703):eadh4567. doi: 10.1126/science.adh4567. Epub 2024 Jun 28. PMID: 38935717.
Li B, Kugeratski FG, Kalluri R. A novel machine learning algorithm selects proteome signature to specifically identify cancer exosomes. eLife, 2024, 10.7554/eLife.90390.3. PMID: 38529947.
McAndrews KM, Mahadevan KK, Kalluri R. Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses. Cold Spring Harb Perspect Med. 2024 Jul 1;14(7):a041411. PMID: 38191175; PMCID: PMC11216184.
Kapoor KS, Kong S, Sugimoto H, Guo W, Boominathan V, Chen YL, Biswal SL, Terlier T, McAndrews KM, Kalluri R. Single Extracellular Vesicle Imaging and Computational Analysis Identifies Inherent Architectural Heterogeneity. ACS Nano. 2024 May 7;18(18):11717-11731. Epub 2024 Apr 23. PMID:38651873.
2023
Mahadevan KK, McAndrews KM, LeBleu VS, Yang S, Lyu H, Li B, Sockwell AM, Kirtley ML, Morse SJ, Moreno Diaz BA, Kim MP, Feng N, Lopez AM, Guerrero PA, Paradiso H, Sugimoto H, Arian KA, Ying H, Barekatain Y, Sthanam LK, Kelly PJ, Maitra A, Heffernan TP, Kalluri R. KRASG12D inhibition
reprograms the tumor microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells. Cancer Cell, e-Pub 8/2023. PMID: 37625401 PMCID: PMC10785700
Mahadevan KK, LeBleu VS, Ramirez EV, Chen Y, Li B, Sockwell AM, Gagea M, Sugimoto H, Tampe D, Zeisberg M, Ying H, Jain AK, DePinho RA, Maitra A, McAndrews KM, Kalluri R. Elimination of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8+ T cells. Developmental Cell. e-Pub 8/2023. PMID: 37625403. PMCID: PMC10810082
LeBleu VS, Dai J, Tsutakawa S, MacDonald BA, Alge JL, Sund M, Xie L, Sugimoto H, Tainer J, Zon LI, Kalluri R. Identification of unique α4 chain structure and conserved anti-angiogenic activity of α3NC1 type IV collagen in zebrafish. Dev Dyn. e-Pub 4/2023. PMID:37002899.
Kalluri R, McAndrews KM. The role of extracellular vesicles in cancer. Cell. 2023 Apr 13;186(8):1610-1626. doi: 10.1016/j.cell.2023.03.010. PMID: 37059067; PMCID: PMC10484374.
2022
Haltom AR, Hassen WE, Hensel J, Kim J, Sugimoto H, Li B, McAndrews KM, Conner MR, Kirtley ML, Luo X, Xie B, Volpert OV, Olalekan S, Maltsev N, Basu A, LeBleu VS, Kalluri R. Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma. Extracell Vesicle. 2022 Dec; 1 PMID: 37503329.
Chen Y, Yang S, Tavormina J, Tampe D, Zeisberg M, Wang H, Mahadevan KK, Wu CJ, Sugimoto H, Chang CC, Jenq RR, McAndrews KM, Kalluri R. Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer. Cancer Cell. e-Pub 7/2022. PMID: 35868307.
McAndrews KM, Miyake T, Ehsanipour EA, Kelly PJ, Becker LM, McGrail DJ, Sugimoto H, LeBleu VS, Ge Y, Kalluri R. Dermal αSMA+ myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production. EMBO J 41(7):e109470, 4/2022. e-Pub 2/2022. PMID: 35212000. PMCID: PMC8982612.
McAndrews KM, Chen Y, Darpolor JK, Zheng X, Yang S, Carstens JL, Li B, Wang H, Miyake T, Correa de Sampaio P, Kirtley ML, Natale M, Wu CC, Sugimoto H, LeBleu VS, Kalluri R. Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer. Cancer Discov 12(6):1580-1597, 6/2022. e-Pub 3/2022. PMID: 35348629.
2021
Chen Y, Yang S, Lovisa S, Ambrose CG, McAndrews KM, Sugimoto H, Kalluri R. Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta. Nat Commun 12(1):7199, 12/2021. e-Pub 12/2021. PMID: 34893625. PMCID: PMC8664945.
McAndrews KM, Xiao F, Chronopoulos A, LeBleu VS, Kugeratski FG, Kalluri R. Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer. Life Sci Alliance 4(9), 9/2021. e-Pub 7/2021. PMID: 34282051. PMCID: PMC8321670.
McAndrews KM, Vázquez-Arreguín K, Kwak C, Sugimoto H, Zheng X, Li B, Kirtley ML, LeBleu VS, Kalluri R. αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression. Oncogene 40(26):4440-4452, 7/2021. e-Pub 6/2021. PMID: 34108617. PMCID: PMC9150816.
Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R. Quantitative proteomics identifies the core proteome of exosomes with syntenin-1 as the highest abundant protein and a putative universal biomarker. Nat Cell Biol 23(6):631–641, 6/2021. e-Pub 6/2021. PMCID: PMC9290189.
Tang M, Chen Y, Li B, Sugimoto H, Yang S, Yang C, LeBleu VS, McAndrews KM, Kalluri R. Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis. FASEB J 35(5):e21557, 5/2021. PMID: 33855751.
Zhou X, Kurywchak P, Wolf-Dennen K, Che SPY, Sulakhe D, D'Souza M, Xie B, Maltsev N, Gilliam TC, Wu CC, McAndrews KM, LeBleu VS, McConkey DJ, Volpert OV, Pretzsch SM, Czerniak BA, Dinney CP, Kalluri R. Unique somatic variants in DNA from urine exosomes of individuals with bladder cancer. Mol Ther Methods Clin Dev 22:360-376, 9/2021. e-Pub 5/2021. PMID: 34108659. PMCID: PMC8408559.
Chen Y, Kim J, Yang S, Wang H, Wu CJ, Sugimoto H, LeBleu VS, Kalluri R. Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer. Cancer Cell 39(4):548-565.e6, 4/2021. e-Pub 3/2021. PMID: 33667385. PMCID: PMC8423173.
Zhou X, Xiao F, Sugimoto H, Li B, McAndrews KM, Kalluri R. Acute kidney injury instigates malignant renal cell carcinoma via CXCR2 in mice with inactivated Trp53 and Pten in proximal tubular kidney epithelial cells. Cancer Res 10.1158/0008-5472.CAN-20-2930, online ahead of print(10):2690-2702, 5/2021. e-Pub 2/2021. PMID: 33558337.
Carstens JL, Yang S, Correa de Sampaio P, Zheng X, Barua S, McAndrews KM, Rao A, Burks JK, Rhim AD, Kalluri R. Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer. Cell Rep 35(2):108990, 4/2021. PMID: 33852841. PMCID: PMC8078733.
Kugeratski FG, McAndrews KM, Kalluri R. Multifunctional applications of engineered extracellular vesicles in the treatment of cancer. Endocrinology 162(3), 3/2021. PMID: 33411885. PMCID: PMC8502448.
Parchem JG, Kanasaki K, Lee SB, Kanasaki M, Yang JL, Xu Y, Earl KM, Keuls RA, Gattone VH, Kalluri R. STOX1 deficiency is associated with renin-mediated gestational hypertension and placental defects. JCI Insight 6(2), 1/2021. e-Pub 1/2021. PMID: 33301424. PMCID: PMC7934881.
McAndrews KM, Che SPY, LeBleu VS, Kalluri R. Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity. J Biol Chem 296:100523, Jan-Jun, 1/2021. e-Pub 3/2021. PMID: 33711340. PMCID: PMC8042450
2020
McAndrews KM, Chen Y, Kalluri R. Stromal cells exhibit prevalent genetic aberrations in colorectal cancer. Cancer Cell 38(6):774–775, 12/2020. PMID: 33321084.
Hensel J, McAndrews KM, McGrail DJ, Dowlatshahi DP, LeBleu VS, Kalluri R. Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses. Sci Rep 10(1):18377, 10/2020. e-Pub 10/2020. PMCID: PMC7591473.
Kugeratski FG, Kalluri R. Exosomes as mediators of immune regulation and immunotherapy in cancer. FEBS J 288(1):10-35, 1/2021. e-Pub 10/2020. PMID: 33110184. PMCID: PMC9116040.
Chronopoulos A, Kalluri R. Emerging role of bacterial extracellular vesicles in cancer. Oncogene 39(46):6951-6960, 11/2020. e-Pub 10/2020. PMID: 33060855. PMCID: PMC7557313.
McAndrews KM, Kalluri R. A map of human breast cancer: new players in stromal-immune crosstalk. EMBO J 39(19):e106368, 10/2020. e-Pub 9/2020. PMID: 32909627. PMCID: PMC7527925.
Xunian Z, Kalluri R. Biology and therapeutic potential of mesenchymal stem cell-derived exosomes. Cancer Sci 111(9):3100-3110, 9/2020. e-Pub 7/2020. PMCID: PMC7469857.
McGrail DJ, Dai J, McAndrews KM, Kalluri R. Enacting national social distancing policies corresponds with dramatic reduction in COVID19 infection rates. PLoS One 15(7):e0236619, 2020. e-Pub 7/2020. PMID: 32639675. PMCID: PMC7392246.
McAndrews KM, Dowlatshahi DP, Dai J, Becker LM, Hensel J, Snowden LM, Leveille JM, Brunner MR, Holden KW, Hopkins NS, Harris AM, Kumpati J, Whitt MA, Lee JJ, Ostrosky-Zeichner LL, Papanna R, LeBleu VS, Allison JP, Kalluri R. Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity. JCI Insight 5(18), 9/2020. e-Pub 9/2020. PMID: 32796155. PMCID: PMC7526535.
Becker LM, O'Connell JT, Vo AP, Cain MP, Tampe D, Bizarro L, Sugimoto H, McGow AK, Asara JM, Lovisa S, McAndrews KM, Zielinski R, Lorenzi PL, Zeisberg M, Raza S, LeBleu VS, Kalluri R. Epigenetic reprogramming of cancer-associated fibroblasts deregulates glucose metabolism and facilitates progression of breast cancer. Cell Rep 31(9):107701, 6/2020. PMID: 32492417. PMCID: PMC7339325.
Lovisa S, Fletcher-Sananikone E, Sugimoto H, Hensel J, Lahiri S, Hertig A, Taduri G, Lawson E, Dewar R, Revuelta I, Kato N, Wu CJ, Bassett RL, Putluri N, Zeisberg M, Zeisberg EM, LeBleu VS, Kalluri R. Endothelial-to-Mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis. Sci Signal 13(635), 6/2020. e-Pub 6/2020. PMID: 32518142. PMCID: PMC7790440.
LeBleu VS, Kalluri R. Exosomes as a multicomponent biomarker platform in cancer. Trends Cancer 6(9):767-774, 9/2020. e-Pub 4/2020. PMID: 32307267.
Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science 367(6478), 2/2020. PMID: 32029601. PMCID: PMC7717626.
2019
McAndrews KM, LeBleu VS, Kalluri R. SIRT1 regulates lysosome function and exosome secretion. Dev Cell 49(3):302-303, 5/2019. PMID: 31063745.
McAndrews KM, Kalluri R. Nischarin regulates secretion of exosomes and cancer progression. Cancer Res 79(9):2099-2101, 5/2019. PMID: 31043427.
McAndrews KM, Kalluri R. Mechanisms associated with biogenesis of exosomes in cancer. Mol Cancer 18(1):52, 3/2019. e-Pub 3/2019. PMID: 30925917. PMCID: PMC6441149.
LeBleu VS, Kalluri R. Exosomes exercise inhibition of anti-tumor immunity during chemotherapy. Immunity 50(3):547-549, 3/2019. PMID: 30893584.
2018
Chen Y, Keskin D, Sugimoto H, Kanasaki K, Phillips PE, Bizarro L, Sharpe A, LeBleu VS, Kalluri R. Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis. PLoS Biol 16(12):e2005907, 12/2018. e-Pub 12/2018. PMID: 30592710. PMCID: PMC6310240.
Parchem JG, Kanasaki K, Kanasaki M, Sugimoto H, Xie L, Hamano Y, Lee SB, Gattone VH, Parry S, Strauss JF, Garovic VD, McElrath TF, Lu KH, Sibai BM, LeBleu VS, Carmeliet P, Kalluri R. Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice. J Clin Invest 128(11):5008-5017, 11/2018. e-Pub 10/2018. PMID: 30179860. PMCID: PMC6205389.
Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Saur D, Kalluri R. Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program. EMBO Mol Med 10(10), 10/2018. e-Pub 8/2018. PMID: 30120146. PMCID: PMC6180301.
Eikesdal HP, Becker LM, Teng Y, Kizu A, Carstens JL, Kanasaki K, Sugimoto H, LeBleu VS, Kalluri R. BMP7 signaling in TGFBR2-deficient stromal cells provokes epithelial carcinogenesis. Mol Cancer Res 16(10):1568-1578, 10/2018. e-Pub 6/2018. PMID: 29934328. PMCID: PMC6170697.
Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, Marszalek JR, Maitra A, Yee C, Rezvani K, Shpall E, LeBleu VS, Kalluri R. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight 3(8), 4/2018. e-Pub 4/2018. PMID: 29669940. PMCID: PMC5931131.
LeBleu VS, Kalluri R. A peek into cancer-associated fibroblasts: Origins, functions and translational impact. Dis Model Mech 11(4), 4/2018. e-Pub 4/2018. PMID: 29686035. PMCID: PMC5963854.
Lovisa S, Kalluri R. Fatty acid oxidation regulates the activation of endothelial-to-mesenchymal transition. Trends Mol Med 24(5):432-434, 5/2018. e-Pub 3/2018. PMID: 29573973.
Kurywchak P, Tavormina J, Kalluri R. The emerging roles of exosomes in the modulation of immune responses in cancer. Genome Med 10(1):23, 3/2018. e-Pub 3/2018. PMID: 29580275. PMCID: PMC5868069.
2017
Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Ruivo CF, Melo SA, Lee JJ, Kalluri R. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature 546(7659):498-503, 6/2017. e-Pub 6/2017. PMID: 28607485. PMCID: PMC5538883.
Kurywchak P, Kalluri R. An evolving function of DNA-containing exosomes in chemotherapy-induced immune response. Cell Res 27(6):722-723, 6/2017. e-Pub 5/2017. PMID: 28524163. PMCID: PMC5518880.
Kalluri R, LeBleu VS. Discovery of double-stranded genomic DNA in circulating exosomes. Cold Spring Harb Symp Quant Biol 81:275-280, 2016. e-Pub 4/2017. PMID: 28424339.
Carstens JL, Correa de Sampaio P, Yang D, Barua S, Wang H, Rao A, Allison JP, LeBleu VS, Kalluri R. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer. Nat Commun 8:15095, 4/2017. e-Pub 4/2017. PMID: 28447602. PMCID: PMC5414182.
Yang S, Che SP, Kurywchak P, Tavormina JL, Gansmo LB, Correa de Sampaio P, Tachezy M, Bockhorn M, Gebauer F, Haltom AR, Melo SA, LeBleu VS, Kalluri R. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. Cancer Biol Ther 18(3):0, 3/2017. e-Pub 1/2017. PMID: 28121262. PMCID: PMC5389423.
2016
Tampe B, Steinle U, Tampe D, Carstens JL, Korsten P, Zeisberg EM, Müller GA, Kalluri R, Zeisberg M. Low-dose hydralazine prevents fibrosis in a murine model of acute kidney injury-to-chronic kidney disease progression. Kidney Int 91(1):157-176, 1/2017. e-Pub 9/2016. PMID: 27692563.
Kalluri R. The biology and function of fibroblasts in cancer. Nat Rev Cancer 16(9):582-98, 8/2016. PMID: 27550820.
Lovisa S, Zeisberg M, Kalluri R. Partial epithelial-to-mesenchymal transition and other new mechanisms of kidney fibrosis. Trends Endocrinol Metab 27(10):681-95, 10/2016. e-Pub 6/2016. PMID: 27372267.
Kalluri R. The biology and function of exosomes in cancer. J Clin Invest 126(4):1208-15, 4/2016. e-Pub 4/2016. PMID: 27035812. PMCID: PMC4811149.
2015
Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature 527(7579):525-30, 11/2015. e-Pub 11/2015. PMID: 26560028.
Zeisberg M, Kalluri R. Physiology of the renal interstitium. Clin J Am Soc Nephrol 10(10):1831-40, 10/2015. e-Pub 3/2015. PMID: 25813241. PMCID: PMC4594057.
Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med 21(9):998-1009, 9/2015. e-Pub 8/2015. PMID: 26236991. PMCID: PMC4587560.
Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature 523(7559):177-82, 7/2015. e-Pub 6/2015. PMID: 26106858.
Keskin D, Kim J, Cooke VG, Wu CC, Sugimoto H, Gu C, De Palma M, Kalluri R, LeBleu VS. Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep 10(7):1066-81, 2/2015. e-Pub 2/2015. PMID: 25704811. PMCID: PMC4342328.
2014
Ayala de la Peña F, Kanasaki K, Kanasaki M, Vong S, Rovira C, Kalluri R. Specific activation of K-RasG12D allele in the bladder urothelium results in lung alveolar and vascular defects. PLoS One 9(4):e95888, 2014. e-Pub 4/2014. PMID: 24760005.
Melo SA, Sugimoto H, O'Connell JT, Kato N, Villanueva A, Vidal A, Qiu L, Vitkin E, Perelman LT, Melo CA, Lucci A, Ivan C, Calin GA, Kalluri R. Cancer exosomes perform cell-independent microRNA biogenesis and promote tumorigenesis. Cancer Cell 26(5):707-21, 11/2014. e-Pub 10/2014. PMID: 25446899. PMCID: PMC4254633.
Miyake T, Kalluri R. Cardiac biology: Cell plasticity helps hearts to repair. Nature 514(7524):575-6, 10/2014. e-Pub 10/2014. PMID: 25317554.
Zeisberg M, Tampe B, LeBleu V, Tampe D, Zeisberg EM, Kalluri R. Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure. Am J Pathol 184(10):2687-98, 10/2014. e-Pub 8/2014. PMID: 25111226. PMCID: PMC4715225.
LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol 16(10):992-1003, 10/2014. e-Pub 9/2014. PMID: 25241037. PMCID: PMC4369153.
Ozdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell 25(6):719-34, 6/2014. e-Pub 5/2014. PMID: 24856586.
Carstens JL, Lovisa S, Kalluri R. Microenvironment-dependent cues trigger miRNA-regulated feedback loop to facilitate the EMT/MET switch. J Clin Invest 124(4):1-3, 4/2014. e-Pub 3/2014. PMID: 24642461. PMCID: PMC3973103.
Kahlert C, Melo SA, Protopopov A, Tang J, Seth S, Koch M, Zhang J, Weitz J, Chin L, Futreal A, Kalluri R. Identification of double stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J Biol Chem 289(7):3869-75, 2/2014. e-Pub 1/2014. PMID: 24398677. PMCID: PMC3924256.
2013
LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. Origin and function of myofibroblasts in kidney fibrosis. Nat Med 19(8):1047-53, 8/2013. e-Pub 6/2013. PMID: 23817022.
Zeisberg M, Kalluri R. The kielin/chordin-like protein checkpoint constitutes a system of checks and balances in CKD. J Am Soc Nephrol 24(6):863-5, 5/2013. e-Pub 5/2013. PMID: 23687357.
Duncan MB, Yang C, Tanjore H, Boyle PM, Keskin D, Sugimoto H, Zeisberg M, Olsen BR, Kalluri R. Type XVIII collagen is essential for survival during acute liver injury in mice. Dis Model Mech 6(4):942-51, 7/2013. e-Pub 4/2013. PMID: 23580202. PMCID: PMC3701214.
Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med 19(7):810-1, 7/2013. PMID: 23836214.
Kahlert C, Kalluri R. Exosomes in tumor microenvironment influence cancer progression and metastasis. J Mol Med (Berl) 91(4):431-7, 4/2013. e-Pub 3/2013. PMID: 23519402.
Melo SA, Kalluri R. miR-29b moulds the tumour microenvironment to repress metastasis. Nat Cell Biol 15(2):139-40, 2/2013. PMID: 23377028.
LeBleu VS, Teng Y, O'Connell JT, Charytan D, Müller GA, Müller CA, Sugimoto H, Kalluri R. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. Nat Med 19(2):227-31, 2/2013. e-Pub 1/2013. PMID: 23353556.
2012
Borges FT, Melo SA, Ozdemir BC, Kato N, Revuelta I, Miller CA, Gattone VH 2nd, Lebleu VS, Kalluri R. TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis. J Am Soc Nephrol. e-Pub 12/2012. PMID: 23274427
Medici D, Kalluri R. Endothelial-mesenchymal transition and its contribution to the emergence of stem cell phenotype. Semin Cancer Biol 22(5-6):379-84, 10/2012. e-Pub 4/2012. PMID: 22554794. PMCID: PMC3422405.
Melo SA, Kalluri R. Molecular pathways: MicroRNAs as cancer therapeutics. Clin Cancer Res 18(16):4234-9, 8/2012. e-Pub 6/2012. PMID: 22711704.
Melo SA, Kalluri R. Angiogenesis is controlled by miR-27b associated with endothelial tip cells. Blood 119(11):2439-40,3/2012. PMID: 22422815.
Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med 18(3):396-404, 3/2012. e-Pub 2/2012. PMID: 22306733.
Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell 21(1):66-81, 1/2012. PMID: 22264789.
Complete List
A complete listing of Dr. Kalluri's publications is online at his NCBI Bibliography