Relevant Publications

Gardner EE, Gay CM. Exclusion of immune cells by vascular gates. Trends in Cancer. 2026 Jul 9:S2405-8033(26)00138-X. doi: 10.1016/j.trecan.2026.06.010. Online ahead of print.

Sanchez-Cespedes M, Lockwood WW, Suda K, Gardner EE, Mitsudomi T, Politi K, Rolfo C, Sen T, Sos ML, Tammela T, Wynes MW, Tsao MS, Berger AH. Tolerance and Resistance to Targeted Therapy in NSCLC:  Emerging Concepts and Strategies. JTO Clin Res Rep 2025 Dec 11;7(4):100944. doi: 10.1016/j.jtocrr.2025.100944. eCollection 2026 Apr.

Earlie EM, Gardner EE, Varmus H, Laughney AM. Dissecting Histological Transformation. Trends in Cancer Jun;12(6):485-494. doi: 10.1016/j.trecan.2026.02.001. Epub 2026 Mar 26.

Parang B, Yoffe L, Khan R, Li Z, Nagiec MJ, Gardner EE, Shieh Y, Heise RS, Saxena A, Altorki N, Blenis J. Propionate metabolism is dysregulated in non-small cell lung cancer patients and EGFR-mutant drug-tolerant persister cells. Scientific Reports 2026 Mar 18. doi: 10.1038/s41598-026-44451-2

Li X, Gardner EE, Molina-Pinelo S, Wilhelm C, Mu P, Quintanal-Villalonga Á. Lineage plasticity and histological transformation:  tumor histology as a spectrum. 2025 Cell Research. 2025 Nov;35(11):803-823. doi: 10.1038/s41422-025-01180-x. Epub 2025 Sep 30.

Chen HJ*, Gardner EE*, Shah Y, Zhang K, Thakur A, Zhang C, Elemento O, Varmus H. Metastatic small cell lung cancer arises from TP53/RB1-deficient and MYC overproduction hESC-derived PNECs. eLife 2025 Jul 22;13:RP93170.

Gardner EE^#, Earlie EM, Li K, Thomas J, Hubisz, Stein BD, Zhang C, Cantley LC, Laughney AM^#, Varmus H^#. Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science 2024 Feb 9;383(6683):eadj1415

Stein B, Ferrone JR, Gardner EE, Chang JW, Wu D, Hollstein PE, Liang RJ, Yuan M, Chen Q, Coukos JS, Sindelar M, Ngo B, Gross SS, Shaw RJ, Zhang C, Asara JM, Moellering RE, Varmus H, Cantley LC. LKB1-Dependent Regulation of TPI1 Creates a Divergent Metabolic Liability between Human and Mouse Lung Adenocarcinoma. Cancer Discovery 2023 Apr 3;13(4):1002-1025.

Vaishnavi A, Juan J, Jacob M, Stehn C, Gardner EE, Scherzer MT, Schuman S, Van Veen JE, Murphy B, Hackett CS, Dupuy AJ, Chmura SA, van der Weyden L, Newberg JY, Liu A, Mann K, Rust AG, Weiss WA, Kinsey CG, Adams DJ, Grossmann A, Mann MB, McMahon M. Transposon Mutagenesis Reveals RBMS3 Silencing as a Promoter of Malignant Progression of BRAFV600E-Driven Lung Tumorigenesis. Cancer Research 2022 Nov 15;82(22):4261-4273.

Gardner EE, Lok BH, Schneeberger VE, Miles LA, Arnold PK, Desmeules P, Ni A, Khodos I, de Stanchina E, Rekhtman N, Nguyen T, Sage J, Ribich S, Dowlati A, Massion PP, Poirier JT, Rudin CM. Chemosensitive relapse in small cell lung cancer proceeds through an EZH2-SLFN11 axis. Cancer Cell. 2017;31(2):286-299.