Di Pilato Laboratory
Mauro Di Pilato, Ph.D.
Areas of Research
- Tumor Microenvironment
The Di Pilato Laboratory investigates the mechanisms that regulate T cell stability and infiltration in cancer. Specifically, we want to understand how antigen-presenting cells control Treg reprogramming and accumulation within the tumor microenvironment. Our final goal is to develop new strategies for patients that do not respond to current cancer immunotherapies.
By combining genetic mouse models and analyses of human cancer samples, the Di Pilato Laboratory wants to identify which key signals are necessary for intratumoral Treg destabilization and expansion in order to finally provide new individualized immunotherapy approaches to patients.
Our primary interests are understanding how tumor-associated neutrophils control regulatory T cell activation and effector T cell dysfunction and determining which chemokine are involved in their intratumoral accumulation and survival.