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Req #: 206100-00007
Job Title:  Postdoctoral Fellow
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​The mission of our lab is to investigate the mechanisms that regulate T cell destabilization and infiltration in cancer. Specifically, we want to understand how antigen-presenting cells control Treg reprogramming and accumulation within the tumor microenvironment. Our final goal is to develop new strategies for patients that do not respond to current cancer immunotherapies.

Learning Objectives:
​By combining genetic mouse models and analyses of human cancer samples, the successful candidates are expected to identify which key signals are necessary for intratumoral Treg instability and expansion in order to finally provide new individualized immunotherapy approaches to patients.

Eligibility Requirements:
Ph.D. in life or physical sciences (examples: immunology, biology, bioinformatics, physics)

Record of successful first author publications

Expertise in flow-cytometry and/or analysis of high-dimensional biological datasets

Experience in mouse models, single cell genomics, molecular cloning and microscopy

Mentor Matching:
This position reports to Mauro Di Pilato, Ph.D.

Additional Application Information:
Two postdoctoral training positions are available in the laboratory of Mauro Di Pilato in the Department of Immunology at University of Texas MD Anderson Cancer Center. 

Req. #: 137722
Job Title: Senior Research Assistant - Immunology
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Responsibilities:

Tissue Culture

1. Maintains and establishes tissue culture cell lines, which requires good sterile technique and ability to determine cell counts and cell viability using microscope and hemocytometer.
2. Monitors, orders and shelves tissue culture supplies.
3. Works with primary human leukocytes and tumor biopsy samples
4. Establishes short-term cell cultures using human or mouse tissues.
5. Some protocols require work on weekends/holidays and time away must be coordinated with other staff to ensure cell lines are maintained.
6. Requires cultivation of viral vectors

Lab Functions

1. Successfully completes training and certification by the Department of Veterinary Medicine to handle and work with live animals, primarily mice, in a safe and humane manner, following institutional guidelines for disposal of dead animals, biohazards and used needles.
2. Setting up breedings, weanings, transferring cages between rooms, ear tagging and tail snipping, and updating lab, breeding and genotyping records.
3. Performs Basic to intermediate techniques in immunological research, including ELISA, ELISPOT, Immune cell isolation, Flow cytometry, Western Blotting, DNA/RNA extraction, PCR, SDS-PAGE gels, Cloning.
4. Requires a willingness to learn techniques for handling chemicals
5. Requires the ability to calculate molarity and accurately prepare media solutions and reagents.
6. Uses acids and polyacrylamide solutions, flammable materials and other biohazards according to OSHA and institutional safety policies.
7. Discusses goals of projects and strategy for attaining the goals with supervisor in clear and concise manner.
8. Ensures safe and efficient functioning of the lab and pleasant work environment for self and others.
9. Responsible for ordering and maintaining laboratory supplies.
10.  Develops research protocols.
11. Assists in the design of laboratory experiments and techniques.
    
12.  Instructs other staff and students in basic laboratory techniques and to discuss project goals and strategies.

Lab Maintenance

1. Responsible for ordering laboratory animals, and maintaining up-to-date animal inventory.
2. Maintains detailed written reports of experimental data and protocols.
3. Maintains lab work area and lab equipment, monitoring it daily to ensure the lab operates safely, is clean, and all equipment is in good working order; understands correct operation of all lab equipment, and follows written instructions/operations manuals.
   
4. Other duties as assigned.
   

Eligibility Requirements:

Bachelor's degree in one of the natural sciences or related field

Three years of experience in scientific or experimental research work

With preferred degree, one year of required experience

MD Anderson Equal Employment Opportunity Statement: It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law.