Publications
2025
Soluble E-cadherin Drives Brain Metastasis in Inflammatory Breast Cancer. Hu X, Xiong Y, Villodre ES, Zhang H, Song J, Fowlkes N, Krishnamurthy S, Rylander M, Bartholomeusz C, Tripathy D; MD Anderson Inflammatory Breast Cancer Team; Woodward WA, Chen J, Debeb BG. bioRxiv [Preprint]. 2025 Jun 24:2025.06.18.660428. doi: 10.1101/2025.06.18.660428
Inhibition of MCL-1 and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers. Mughees M, Tacam M, Tan AW, Pitner MK, Iles LR, Hu X, Villodre ES, Debeb BG, Kogawa T, Lim B, Layman RM, Woodward WA, Ueno NT, Tripathy D, Krishnamurthy S, Qi Y, Pusztai L, Wang J, Gandhi V, Bartholomeusz G, Bartholomeusz C. Mol Cancer Ther. 2025 Sep 2;24(9):1453-1465. doi: 10.1158/1535-7163.MCT-24-0593
2024
NDRGs in Breast Cancer: A Review and In Silico Analysis. Villodre ES, Nguyen APN, Debeb BG. Cancers (Basel). 2024 Mar 29;16(7):1342. doi: 10.3390/cancers16071342
In Vivo Simvastatin and Brain Radiation in a Model of HER2+ Inflammatory Breast Cancer Brain Metastasis. Kumar S, Larson RA, Stecklein S, Reddy J, Debeb BG, Amos RA, Cologna SM, Woodward WA. bioRxiv [Preprint]. 2024 May 30:2024.05.25.595905. doi: 10.1101/2024.05.25.595905
Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy. Yin L, Hu X, Pei G, Tang M, Zhou Y, Zhang H, Huang M, Li S, Zhang J, Citu C, Zhao Z, Debeb BG, Feng X, Chen J. Life Sci Alliance. 2024 Feb 5;7(4): e202302353. doi: 10.26508/lsa.202302353
2023
High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells. Balema W, Morton J, Larson RA, Li L, Velasquez FC, Fowlkes NW, Krishnamurthy S, Debeb BG, Sevick-Muraca E, Woodward WA. J Mammary Gland Biol Neoplasia. 2023 Oct 6;28(1):21. doi: 10.1007/s10911-023-09548-8
Influence of Macrophages on Vascular Invasion of Inflammatory Breast Cancer Emboli Measured Using an In Vitro Microfluidic Multi-Cellular Platform. Gadde M, Mehrabi Dehdezi M, Debeb BG, Woodward WA, Rylander MN. Cancers (Basel). 2023 Oct 8;15(19):4883. doi: 10.3390/cancers15194883
2022
Response to de Nonneville, Finetti, Mamessier, and Bertucci. Villodre ES, Hu X, Huo L, Debeb BG. J Natl Cancer Inst. 2022 Jul 11;114(7):1048-1049. doi: 10.1093/jnci/djac032
2021
NDRG1 in Aggressive Breast Cancer Progression and Brain Metastasis. Villodre, ES; Hu, X; Eckhardt, BL; Larson, R; Huo, L; Yoon, EC; Gong, Y; Song, J; Liu, S; Ueno, NT; Krishnamurthy, S; Pusch, S; Tripathy, D; Woodward, WA;. Debeb, BG. Journal of the National Cancer Institute, 2021; djab222, DOI: 10.1093/jnci/djab222
Inflammatory breast cancer appearance at presentation is associated with overall survival. Balema W, Liu D, Shen Y, El-Zein R, Debeb BG, Kai M, Overmoyer B, Miller KD, Le-Petross HT, Ueno NT, Woodward WA. Cancer Med. e-Pub 2021. PMCID: PMC8446552
Lipocalin 2 promotes inflammatory breast cancer tumorigenesis and skin invasion. Villodre, ES; Hu, X; Larson, R; Finetti, P; Gomez, K; Balema, W; Stecklein, SR; Santiago-Sánchez, GS; Krishnamurthy, S; Song, J; Su, X; Ueno, NT; Tripathy, T; Van Laere, S; Bertucci, F; Vivas-Mejía, P; Woodward, WA; Debeb, BG. Molecular Oncology, 2021. PMCID: PMC8486564
Targeting Lipocalin-2 in inflammatory breast cancer cells with small interference RNA and small molecule inhibitors. Santiago-Sánchez, GS; Noriega-Rivera, R; Hernández-O’Farrill, E; Valiyeva, F; Quiñones-Diaz, B; Villodre, ES; Debeb, BG; Rosado-Albacarys, A; Vivas-Mejía, PE. International Journal of Molecular Sciences, 22, 8581, 2021. PMCID: PMC8395282
Modeling Brain Metastasis Via Tail-Vein Injection of Inflammatory Breast Cancer Cells. Hu, X*; Villodre, ES*; Woodward, WA; Debeb, BG. J. Vis. Exp., 168, e62249, 2021. DOI: 10.3791/62249
Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis. Fukumura, K; Malgulwar, PB; Fischer, GM; Hu, X; Mao, X; Song, X; Hernandez, SD; Zhang, XH; Zhang, J; Parra, ER; Yu, D; Debeb, BG; Davies, MA; Huse, JT. Acta Neuropathol 141(2):303-321, 2/2021. DOI: 10.1007/s00401-020-02256-1
Decorin-mediated suppression of tumorigenesis, invasion, and metastasis in inflammatory breast cancer. Hu, X; Villodre, ES; Larson, R; Rahal, OM; Wang, X; Gong, Y; Song, J; Krishnamurthy, S; Ueno, NT; Tripathy, D; Woodward, WA; Debeb, BG. Communications Biology, 4, 72, 2021. PMCID: PMC7811004
Prophylactic cranial irradiation reduces the incidence of brain metastasis in a mouse model of metastatic, HER2-positive breast cancer. Smith DL, Debeb BG, Diagaradjane P, Larson R, Kumar S, Ning J, Lacerda L, Li L, Woodward WA. Genes Cancer 12:28-38, 2021. PMCID: PMC8045965
2020
NDRG1 expression is an independent prognostic factor in inflammatory breast cancer. Villodre, ES; Gong Y, Hu X, Huo L, Yoon EC, Ueno NT, Woodward WA, Tripathy D, Song J, Debeb BG. Cancers, 12, 3711, 2020. PMCID: PMC7763268
Differential functions of ERK1 and ERK2 in lung metastasis processes in triple-negative breast cancer. Gagliardi M, Pitner MK, Park J, Xie X, Saso H, Larson RA, Sammons RM, Chen H, Wei C, Masuda H, Chauhan G, Kondo K, Tripathy D, Ueno NT, Dalby KN, Debeb BG, Bartholomeusz C. Sci Rep 10(1):8537; 2020; PMCID: PMC7244517
NOTCH and DNA repair pathways are more frequently targeted by genomic alterations in inflammatory than in non-inflammatory breast cancers. Bertucci F, Rypens C, Finetti P, Guille A, Adélaïde J, Monneur A, Carbuccia N, Garnier S, Dirix P, Gonçalves A, Vermeulen P, Debeb BG, Wang X, Dirix L, Ueno NT, Viens P, Cristofanilli M, Chaffanet M, Birnbaum D, Van Laere S. Mol Oncol 14(3):504-519; 2020 PMCID: PMC7053236