Publications

Preprint: Xie W, Gowder M, Bazzano D, Shami AN, Pandey A, Frasca M, Paniker L, de Almeida LP, Bharati BK, Liang J, Tóth A, DeSantis M, Nandakumar J, Nudler E, Mosalaganti S, Pezza R, Cole F, Hammoud SS. ZCWPW1 organizes telomeric architecture to drive meiotic chromosome movements.  bioRxiv [Preprint]. 2026 Feb 2:2026.01.30.702899. doi: 10.64898/2026.01.30.702899. PMID: 41676639 

Frasca M, Paniker L, Kang R, Chakraborty P, Pandey A, LoPresti J, Cole F. MutSgamma promotes meiotic recombination and homolog pairing in mouse spermatocytes. Genetics. 2025 Jul 9;230(3):iyaf099. PMID: 40404295

Premkumar T, Paniker L, Kang R, Biot M, Humphrey E, Destain H, Ferranti I, Okulate I, Nguyen H, Kilaru V, Frasca M, Chakraborty P, Cole F. Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis. Mol Cell. 2023 Aug 17;83(16):2941-2958. PMID: 37595556 

Toraason E, Horacek A, Clark C, Glover ML, Adler VL, Premkumar T, Salagean A, Cole F, Libuda DE. Meiotic DNA break repair can utilize homolog-independent chromatid templates in C. elegans. Curr Biol. 2021 Apr 12;31(7):1508-1514.e5. PMID: 33740427 

Patel L#, Kang R#, Rosenberg SC, Qiu Y, Raviram R, Chee S, Hu R, Ren B, Cole F*, Corbett KD*. Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase. Nat Struct Mol Biol. 2019 Mar;26(3):164-174. (#co-first authors; *co-corresponding authors) PMID: 30778236 

Zelazowski MJ, Sandoval M, Paniker L, Hamilton HM, Han J, Gribbell MA, Kang R, Cole F. Age-Dependent Alterations in Meiotic Recombination Cause Chromosome Segregation Errors in Spermatocytes. Cell. 2017 Oct 19;171(3):601-614.e13. PMID: 28942922 

Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD. Analysis of DNA polymerase ν function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet. 2017 Jun 1;13(6):e1006818. PMID: 28570559 

Vélez-Cruz R, Manickavinayaham S, Biswas AK, Clary RW, Premkumar T, Cole F, Johnson DG. RB localizes to DNA double-strand breaks and promotes DNA end resection and homologous recombination through the recruitment of BRG1. Genes Dev. 2016 Nov 15;30(22):2500-2512. PMID: 27940962

Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S. SCAI promotes DNA double-strand break repair in distinct chromosomal contexts. Nat Cell Biol. 2016 Dec;18(12):1357-1366. PMID: 27820601 

Li M, Cole F, Patel DS, Misenko SM, Her J, Malhowski A, Alhamza A, Zheng H, Baer R, Ludwig T, Jasin M, Nussenzweig A, Serrano L, Bunting SF. 53BP1 ablation rescues genomic instability in mice expressing 'RING-less' BRCA1. EMBO Rep. 2016 Nov;17(11):1532-1541. PMID: 27670884 

Cole F, Baudat F, Grey C, Keeney S, de Massy B, Jasin M. Mouse tetrad analysis provides insights into recombination mechanisms and hotspot evolutionary dynamics. Nat Genet. 2014 Oct;46(10):1072-80. PMID: 25151354

Cole F, Kauppi L, Lange J, Roig I, Wang R, Keeney S, Jasin M. Homeostatic control of recombination is implemented progressively in mouse meiosis. Nat Cell Biol 2012 Mar 4;14(4):424-30. PMID: 22388890

Lange J, Pan J, Cole F, Thelen MP, Jasin M, Keeney S. ATM controls meiotic double-strand-break formation. Nature. 2011 Oct 16;479(7372):237-40. PMID: 22002603

Shakya R, Reid LJ, Reczek CR, Cole F, Egli D, Lin CS, deRooij DG, Hirsch S, Ravi K, Hicks JB, Szabolcs M, Jasin M, Baer R, Ludwig T. BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity. Science. Oct 28;334(6055):525-8. PMID: 22034435

Cole F, Keeney S, Jasin M. Comprehensive, fine-scale dissection of homologous recombination outcomes at a hot spot in mouse meiosis. Mol Cell. 2010 Sep 10;39(5):700-10. PMID: 20832722 

Zhang W, Kang JS, Cole F, Yi MJ, Krauss RS. Cdo functions at multiple points in the Sonic Hedgehog pathway, and Cdo-deficient mice accurately model human holoprosencephaly. Dev Cell. 2006 May;10(5):657-65. PMID: 16647303

Zhang W, Yi MJ, Chen X, Cole F, Krauss RS, Kang JS. Cortical thinning and hydrocephalus in mice lacking the immunoglobulin superfamily member CDO. Mol Cell Biol. 2006 May;26(10):3764-72. PMID: 16648472 

Tenzen T, Allen BL, Cole F, Kang JS, Krauss RS, McMahon AP. The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev Cell. 2006 May;10(5):647-56. PMID: 16647304 

Krauss RS, Cole F, Gaio U, Takaesu G, Zhang W, Kang JS. Close encounters: regulation of vertebrate skeletal myogenesis by cell-cell contact. J Cell Sci. 2005 Jun 1;118(Pt 11):2355-62. PMID: 15923648. Review.

Bergemann AD, Cole F, Hirschhorn K. The etiology of Wolf-Hirschhorn syndrome. Trends Genet. 2005 Mar;21(3):188-95. PMID: 15734578 Review.

Cole F, Zhang W, Geyra A, Kang JS, Krauss RS. Positive regulation of myogenic bHLH factors and skeletal muscle development by the cell surface receptor CDO. Dev Cell. 2004 Dec;7(6):843-54. PMID: 15572127 

Kang JS, Yi MJ, Zhang W, Feinleib JL, Cole F, Krauss RS. Netrins and neogenin promote myotube formation. J Cell Biol. 2004 Nov 8;167(3):493-504. PMID: 15520228

Cole F, Krauss RS. Microform holoprosencephaly in mice that lack the Ig superfamily member Cdon. Curr Biol. 2003 Mar 4;13(5):411-5. PMID: 12620190

Premkumar T, Paniker L, Kang R, Biot M, Humphrey E, Destain H, Ferranti I, Okulate I, Nguyen H, Kilaru V, Frasca M, Chakraborty P, Cole F. Genetic dissection of crossover mutants defines discrete intermediates in mouse meiosis. bioRxiv

Humphrey E, Cole F. How sex chromosomes break up to get together. (News and Views) Nature. 2020 Jun;582(7812):346-347.

Kang R, Zelazowski MJ, Cole F. Missing the Mark: PRDM9-Dependent Methylation Is Required for Meiotic DSB Targeting. Mol Cell. 2018 Mar 1;69(5):725-727

Zelazowski MJ, Cole F. X marks the spot: PRDM9 rescues hybrid sterility by finding hidden treasure in the genome. Nat Struct Mol Biol. 2016 Apr;23(4):267-9.

Cole F. The sense and sensibility of strand exchange in recombination homeostasis. PLoS Genet. 2014 Jan;10(1):e1004104. 

Cole F, Keeney S, Jasin M. Preaching about the converted: how meiotic gene conversion influences genomic diversity. Ann N Y Acad Sci. 2012 Sep;1267:95-102. 

Cole F, Keeney S, Jasin M. Evolutionary conservation of meiotic DSB proteins: more than just Spo11. Genes Dev 2010 Jun 15;24(12):1201-7.

Cole F, Jasin M. Isolation of meiotic recombinants from mouse sperm. In: Methods Mol Biol. 745, 251-82, 2011. ISBN: 21660699.