Selected Publications

Alonso S, Chu K, Granowsky E, Rabanales VS, Parsons MJ, Gunasinghe H, Shia J, Yaeger R, Dow LE. Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in colorectal cancer. Cancer Cell. 2026 May 21;. doi: 10.1016/j.ccell.2026.04.009. [Epub ahead of print] PubMed PMID: 42167227.

Bild AH, Sangar MC, McQuerry JA, Ideker T, Kopetz S, Carey L, Nath A, Marcus D, Regier A, Rashid N, Barzilay R, Winer E, Salgia R, Malhotra J, Gentles A, Buetow K, Mahmood F, Markman DW, Eddy JA, ADAPT Consortium. The ADAPT learning cancer treatment system: ARPA-H's initiative to revolutionize cancer therapy. Cancer Cell. 2026 Mar 9;44(3):449-454. doi: 10.1016/j.ccell.2025.12.008. Epub 2026 Jan 8. PubMed PMID: 41512871; PubMed Central PMCID: PMC12912820.

Alonso S, Raghav K, Morris VK, Alfaro-Munoz K, Bekaii-Saab T, Cannon TL, Corcoran RB, Duesbery N, George M, Hsu D, Lieu C, Maitra A, Maru D, McQuerry JA, Menter D, Mizrahi J, Ng K, Parikh A, Rai K, Sangar MC, Shaw KR, Shen JP, Strickler JH, Feehan AD, Tam AL, Vetere G, Yaeger R, Yuan Y, Shen X, Bild AH, Kopetz S. Framework for cancer evolution profiling and interception in colorectal cancer: ASCEND-CRC program. Cancer Cell. 2026 Mar 9;44(3):455-459. doi: 10.1016/j.ccell.2025.12.016. Epub 2026 Jan 8. PubMed PMID: 41512869.

Alonso S, Chu K, Parsons MJ, Granowsky E, Gunasinghe H, Shia J, Yaeger R, Dow LE. Concurrent genetic and non-genetic resistance mechanisms to KRAS inhibition in CRC. bioRxiv. 2025 Aug 5;. doi: 10.1101/2025.08.05.668666. PubMed PMID: 40799551; PubMed Central PMCID: PMC12340827.

Villanueva JW, Kwong L, Han T, Martinez SA, Shanahan MT, Kanke M, Dow LE, Danko CG, Sethupathy P. Comprehensive microRNA analysis across genome-edited colorectal cancer organoid models reveals miR-24 as a candidate regulator of cell survival. BMC Genomics. 2022 Dec 1;23(1):792. doi: 10.1186/s12864-022-09018-1. PubMed PMID: 36457077; PubMed Central PMCID: PMC9716731.

Alonso Martinez S, Segal NH, Cercek A, Yaeger R, Stadler Z, Kemeny NE, Nusrat M, Shahrokni A, Connell L, Saltz LB. Simplified Graded Infusion Strategy for Mitigation of Oxaliplatin Hypersensitivity. Clin Colorectal Cancer. 2022 Jun;21(2):149-153. doi: 10.1016/j.clcc.2022.01.006. Epub 2022 Jan 19. PubMed PMID: 35125319; PubMed Central PMCID: PMC9149089.

Alonso S, Dow LE. Engineering chromosome rearrangements in cancer. Dis Model Mech. 2021 Sep 1;14(9). doi: 10.1242/dmm.049078. Epub 2021 Sep 29. Review. PubMed PMID: 34585724; PubMed Central PMCID: PMC8489016.

Alonso S, Saltz L. The Landmark Series: Chemotherapy for Non-Metastatic Colon Cancer. Ann Surg Oncol. 2021 Feb;28(2):995-1001. doi: 10.1245/s10434-020-09375-9. Epub 2020 Nov 23. Review. PubMed PMID: 33230749.

Hernandez D, Palau L, Norsworthy K, Anders NM, Alonso S, Su M, Petkovich M, Chandraratna R, Rudek MA, Smith BD, Jones RJ, Ghiaur G. Overcoming microenvironment-mediated protection from ATRA using CYP26-resistant retinoids. Leukemia. 2020 Nov;34(11):3077-3081. doi: 10.1038/s41375-020-0790-4. Epub 2020 Mar 9. PubMed PMID: 32152463; PubMed Central PMCID: PMC7483812.

Chang YT, Hernandez D, Alonso S, Gao M, Su M, Ghiaur G, Levis MJ, Jones RJ. Role of CYP3A4 in bone marrow microenvironment-mediated protection of FLT3/ITD AML from tyrosine kinase inhibitors. Blood Adv. 2019 Mar 26;3(6):908-916. doi: 10.1182/bloodadvances.2018022921. PubMed PMID: 30898762; PubMed Central PMCID: PMC6436013.

Alonso S, Yilmaz ÖH. Nutritional Regulation of Intestinal Stem Cells. Annu Rev Nutr. 2018 Aug 21;38:273-301. doi: 10.1146/annurev-nutr-082117-051644. Epub 2018 May 23. Review. PubMed PMID: 29799767.

Alonso S, Jones RJ, Ghiaur G. Retinoic acid, CYP26, and drug resistance in the stem cell niche. Exp Hematol. 2017 Oct;54:17-25. doi: 10.1016/j.exphem.2017.07.004. Epub 2017 Jul 25. Review. PubMed PMID: 28754309; PubMed Central PMCID: PMC5603425.

Alonso S, Hernandez D, Chang YT, Gocke CB, McCray M, Varadhan R, Matsui WH, Jones RJ, Ghiaur G. Hedgehog and retinoid signaling alters multiple myeloma microenvironment and generates bortezomib resistance. J Clin Invest. 2016 Dec 1;126(12):4460-4468. doi: 10.1172/JCI88152. Epub 2016 Oct 24. PubMed PMID: 27775549; PubMed Central PMCID: PMC5127663.

Alonso S, Su M, Jones JW, Ganguly S, Kane MA, Jones RJ, Ghiaur G. Human bone marrow niche chemoprotection mediated by cytochrome P450 enzymes. Oncotarget. 2015 Jun 20;6(17):14905-12. doi: 10.18632/oncotarget.3614. PubMed PMID: 25915157; PubMed Central PMCID: PMC4558124.

Su M, Alonso S, Jones JW, Yu J, Kane MA, Jones RJ, Ghiaur G. All-Trans Retinoic Acid Activity in Acute Myeloid Leukemia: Role of Cytochrome P450 Enzyme Expression by the Microenvironment. PLoS One. 2015;10(6):e0127790. doi: 10.1371/journal.pone.0127790. eCollection 2015. PubMed PMID: 26047326; PubMed Central PMCID: PMC4457893.