The goal of the High Resolution Electron Microscopy Facility (HREMF) is to provide high quality electron microscopy services at an affordable price to research investigators at MD Anderson Cancer Center. The facility is located in the Smith Research Building (South Campus) and houses a JEOL JEM1010 transmission electron microscope (TEM), a JEOL JSM5900 scanning electron microscope (SEM), a Technotrade coating system, a Leica ultramicrotome, and a Leica ultrastainer. The HREMF personnel are available to provide research support for investigators who are interested in electron microscopy.
HREMF transmission electron microscopy is featured in high impact publications
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers in Western countries, with a dormant subpopulation of cancer cells being able to survive oncogene ablation and cause tumor relapse. Analysis of surviving cells suggests mitochindorial and and autophagic functions are enhanced. In this work, the authors rely on our expertise with transmission electron microscopy to identify autophagic structures in PDAC cells and to examine the morphology of mitochondria in surviving cancer cells.
Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchex N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 514(7524):628-32, 2014.
Core Grant Citation
Publications using the HREMF should include an acknowledgment of the Cancer Center Core Grant NIH P30CA016672.
The HREMF is located in the R.E. "Bob" Smith Research Building, Room SRB1.660.
7777 Knight Road
Houston, Texas 77030
Robert R. Langley, Ph.D., Director
Kenneth Dunner Jr., B.S. (EM certification, Microscopy Society of America)
Research Laboratory Manager