Functional Proteomic Reverse Phase Protein Array (RPPA) Core
Yiling Lu, Rehan Akbani
Director, Co-Director
- Research Resources
- Core Facilities and Services
- Functional Proteomics RPPA Core Facility
Overview
The Functional Proteomics Reverse Phase Protein Array (RPPA) Core provides investigators with a powerful, high throughput, quantitative, cost-effective technology for functional proteomics studies. We provide centralized, standardized and quality-controlled service to investigators throughout MD Anderson and around the world. The RPPA Core has served several national consortia including TCGA, CCLE and ICBP. Learn more.
Getting Started
- Contact us at ccsgrppa@mdanderson.org or 713-792-5743 for any questions regarding experimental requirements.
Fill out an iLab service request at https://mdanderson.ilabsolutions.com.
The RPPA Core will review the request, and once all information in iLab is correct and complete, will approve the request and provide further instructions for sample submission.
Impact
The Functional Proteomics Reverse Phase Protein Array (RPPA) Core provides high quality, data rich results for both tumor tissue and cultured cells. RPPA characterizes expression levels of basal and modified proteins as well as growth factor‐ or ligand‐induced effects and time‐resolved responses appropriate for systems biology analyses. RPPA provides information to integrate the consequence of genetic aberrations in cancer, validate therapeutic targets, demonstrate on‐ and off‐target activity of drugs, and evaluate drug pharmacodynamics.
Acknowledgement
The RPPA Core is supported by NCI Grant # CA016672 and Dr. Yiling Lu’s NIH R50 Grant # R50CA221675: Functional Proteomics by Reverse Phase Protein Array in Cancer. If your publication uses data generated by the RPPA Core, please cite these grants in the acknowledgement section. Thank you!
Please use the following text in publications: "The Functional Proteomics Reverse Phase Protein Array Core was supported in part by The University of Texas MD Anderson Cancer Center, P30CA016672, and R50CA221675."
Contact
Phone: 713-792-5743 or 832-750-0145
Email: ccsgrppa@mdanderson.org
Facility Location
6565 MD Anderson Blvd., Room Z4.2040
Houston, Texas 77030
Announcement
Due to recent increases in the cost of materials and labor, the RPPA Core has increased the price of all services by 20%. See the Services page for updated pricing.
If you have any questions or concerns, please contact us at ccsgrppa@mdanderson.org or 713-792-5743.
Thank you.
Coming Soon
Updates to The Cancer Proteome Atlas (TCPA) portal.
For a brief introduction about TCPA, check the YouTube video here.