Facility and Equipment
The Cyclotron Radiochemistry Facility (CRF) occupies 13,000 square feet of dedicated laboratory for the manufacturing of PET radiopharmaceuticals under cGMP. A GEHealthcare PETtrace is used for the production of PET radionuclides — 11C, 13N, 15O, and 18F together with a solid target station for the production of unconventional radionuclides — 52Mn, 61Cu, 64Cu, 68Ga, 86Y, 89Zr, etc.
The facility was designed and operates to meet current Good Manufacturing Practices (cGMP). There are seven suites in the CRF, four are utilized for the production of Positron Emission Tomography (PET) radiopharmaceuticals while the other three are dedicated to research and development of new tracers for preclinical studies. Each room has its own dedicated space for quality control of products.
There are a total of 34 hot-cells for radiopharmaceutical manufacturing. Fifteen of those are dedicated mini hot-cells housing automated manufacturing equipment (GE Fastlab and Tracerlab series). Eight full size hot-cells, three of them with remote manipulators permit handling and further processing of products and two hot-cells contain fully automated dispensing equipment. The remaining nine hot-cells are located in the research and development area.
The lab is equipped with multiple radio-HPLC systems, GC and radio-TLC. We also have the following specialized instruments: LC-MS-TOF, GC-MS and two IC systems. The facility also operates a Nuclear Pharmacy for the preparation and dispensing of patient doses.
Charles Manning, Ph.D., Director
Andrew Day, Pharm.D., Staff Radiopharmacist
Roberto Strangis, M.S., Cyclotron Engineering Specialist
Uday Mukhopadhyay, Ph.D., Senior Radiochemist
Vincenzo Paolillo, Ph.D., Senior Radiochemist
Mai Lin, Ph.D., Senior Radiochemist
Renjith Ramachandran, M.S., Drug Manufacturing Quality Specialist
Donald Williams, Radiopharmaceutical Lab Tech
Jennah Gonzales, B.A., Senior Administrative Assistant
Main phone number: 713-563-5455
1881 East Road, Unit 1903
Houston, Texas 77054