Publications

Exploiting metabolic cell death for cancer therapy

Read article in Nature Reviews Cancer Opens a new window

Mao C, Jiang D, Koong AC, Gan B. 2025 Oct 15.

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

Read article in Cancer Cell Opens a new window

Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B. 2025 Jun 9;43(6):1076-1092.e5 

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance.

Read article in Cancer Cell Opens a new window

Lei G, Sun M, Cheng J, Ye R, Lu Z, Horbath A, Huo D, Wu S, Alapati A, Aggarwal S, Xu Z, Mao C, Yan Y, Yao J, Li Q, Chen X, Lee H, Zhuang L, Jiang D, Pataer A, Roth JA, Navin N, Koong AC, You MJ, Lin SH, Gan B. 2025 Jun 9;43(6):1076-1092.e5.

Histone methyltransferase ASH1L primes metastases and metabolic reprogramming of macrophages in the bone niche

Read article in Nature Communications Opens a new window

Meng C, Lin K, Shi W, Teng H, Wan X, DeBruine A, Wang Y, Liang X, Leo J, Chen F, Gu Q, Zhang J, Van V, Maldonado KL, Gan B, Ma L, Lu Y, Zhao D. 2025.0 May 20. 1(16).

Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins.

Read article in Molecular Cancer Opens a new window

Freitas-Cortez MA, Masrorpour F, Jiang H, Mahmud I, Lu Y, Huang A, Duong LK, Wang Q, Voss TA, Kettlun Leyton CS, Wei B, Chan WK, Lin K, Zhang J, Tsouko E, Ganjoo S, Barsoumian HB, Riad TS, Hu Y, Leuschner C, Puebla-Osorio N, Wang J, Hu J, Davies MA, Puduvalli VK, Billon C, Burris TP, Lorenzi PL, Gan B, Welsh JW. 2025.0 Feb 03. 1(24).

Dodging death

Read article in Nature Chem Biol Opens a new window

Yan Y, Gan B. 2024.0 Oct. 10(20).

Rewiring cancer cell death: LPCAT1 shapes lipid composition and ferroptosis resistance.

Read article in Cell Death Differ Opens a new window

Lee H, Zhuang L, Gan B. 2024.0 Sep. 9(31).

Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis

Read article in Protein Cell Opens a new window

Liu X, Chen Z, Yan Y, Zandkarimi F, Nie L, Li Q, Horbath A, Olszewski K, Kondiparthi L, Mao C, Lee H, Zhuang L, Poyurovsky M, Stockwell BR, Chen J, Gan B. 2024.0 Sep 01. 9(15).

Metabolic cell death in cancer: ferroptosis, cuproptosis, disulfidptosis, and beyond

Read article in Protein Cell Opens a new window

Mao C, Wang M, Zhuang L, Gan B. 2024.0 Sep 01. 9(15).

Unraveling ETC complex I function in ferroptosis reveals a potential ferroptosis-inducing therapeutic strategy for LKB1-deficient cancers

Read article in Molecular Cell Opens a new window

Mao C, Lei G, Horbath A, Wang M, Lu Z, Yan Y, Liu X, Kondiparthi L, Chen X, Cheng J, Li Q, Xu Z, Zhuang L, Fang B, Marszalek J, Poyurovsky M, Olszewski K, Gan B. 2024 May 16; 84(10):1964-1979

IRE1α determines ferroptosis sensitivity through regulation of glutathione synthesis

Read article in Nature Communications Opens a new window

Jiang D, Guo Y, Wang T, Wang L, Yan Y, Xia L, Bam R, Yang Z, Lee H, Iwawaki T, Gan B, Koong A. 2024 May 15;15(1):4114

VHL governs m6A modification and PIK3R3 mRNA stability in clear cell renal cell carcinomas

Read article in Journal of Clinical Investigation Opens a new window

Lee H, Zhuang L, Gan B. 2024 Apr 15; 134(8): e179560

The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions

Read article in Cancer Cell Opens a new window

Lei G, Zhuang L, Gan B. 2024 Apr 8;42(4):513-534

Disulfidptosis: disulfide stress-induced cell death

Read article in Trends Cell Biology Opens a new window

Liu X, Zhuang L, Gan B. 2024 Apr;34(4):327-337

Exploring ferroptosis-inducing therapies for cancer treatment: Challenges and opportunities

Read article in Cancer Research Opens a new window

Lei G, Gan B. 2024 Apr 1;84(7):961-964

DePARylation is critical for S phase progression and cell survival

Read article in eLife Opens a new window

Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J. 2024 April 5;12

BRCA1-mediated dual regulation of ferroptosis exposes a vulnerability to GPX4 and PARP co-inhibition in BRCA1-deficient cancers

Read article in Cancer Discovery Opens a new window

Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. 2024 Mar 28

SLC25A39 links mitochondrial GSH sensing with iron metabolism

Read article in Molecular Cell Opens a new window

Chen X, Gan B. 2024 Feb 15;84(4):616-618

Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Read article in Nature Communications Opens a new window

Lee H, Horbath A, Kondiparthi L, Meena JK, Lei G, Dasgupta S, Liu X, Zhuang L, Koppula P, Li M, Mahmud I, Wei B, Lorenzi PL, Keyomarsi K, Poyurovsky MV, Olszewski K, Gan B. 2024 Jan 2;15(1):79

Hyperoxidized PRDX3 as a specific ferroptosis marker

Read article in Life Metabolism Opens a new window

Yan Y, Gan B. 2023 December;2(6).

The pyrimidinosome: Orchestrating pyrimidine biosynthesis and ferroptosis defense

Read article in Molecular Cell Opens a new window

Gan B. 2023 Aug 17; 83 (16) 2837-2839

Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation

Read article in Cell Metabolism Opens a new window

Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung MC, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, Yang L. 2023 August 8;35(8):1457-1473.e13.

Uncovering the IL-1β-PCAF-NNT axis: A new player in ferroptosis and tumor immune evasion

Read article in Cancer Communications Opens a new window

Li Q, Gan B. 2023 Jul 24

Ferroptosis vulnerability in FLT3-mutant leukemia

Read article in Trends in Cancer Opens a new window

Lee H, Zhuang L, Gan B. 2023 Jul; 9 (7) 524-525

SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells

Read article in Nature Communications Opens a new window

Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, Liu X, Mao C, Wu S, Zhuang L, James M, Poyurovsky M, Ma L, Olszewski K, Gan B. 2023 Jun 21; 14 (1) 3673

Ferroptosis hijacking by Mycobacterium tuberculosis

Read article in Nature Communications Opens a new window

Gan B. 2023 Mar 17; 14 (1) 1431

A time and place for inhibiting autophagy

Read article in Cancer Research Opens a new window

Gan B. 2022 Dec 02; 82 (23) 4322-4324