Publications
Chen Y, Yang S, Tavormina J, Tampe D, Zeisberg M, Wang H, Mahadevan K, Wu C-J, Sugimoto H, Chang C-C, Jenq RR, McAndrews KM, Kalluri R. Oncogenic collagen I homotrimers from cancer cells bind to a3b1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer. Cancer Cell. 2022 Aug 8;40(8): 1-17.
Chen Y, Kim J, Yang S, Wang H, Wu C-J, Sugimoto H, LeBleu VS, Kalluri R. Type I collagen deletion in aSMA+ myofibroblasts enhances immune suppression and accelerates progression of pancreatic cancer. Cancer Cell. 2021 Apr 12;39(4): 548-565.e6.
McAndrews KM*, Chen Y*, Darpolor JK*, Zheng X, Yang S, Carstens JL, Li B, Wang H, Miyake T, Correa de Sampaio P, Kirtley ML, Natale M, Wu C-C, Sugimoto H, LeBleu VS, Kalluri R. Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL-6 mediated therapy resistance in pancreatic cancer. Cancer Discovery. 2022 Jun 2;12(6):1580-1597. (*Co-first author)
Chen Y, Yang S, Lovisa S, Ambrose CG, McAndrews KM, Sugimoto H, Kalluri R. Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta. Nature Communications. 2021 Dec 10;12(1):7199.
Chen Y, McAndrews KM, Kalluri R. Clinical and therapeutic relevance of cancer-associated fibroblasts. Nature Reviews Clinical Oncology. 2021 Dec;18(12):792-804.
Chen Y, Keskin D, Sugimoto H, Kanasaki K, Phillips PE, Bizarro L, Sharpe A, LeBleu VS, Kalluri R. Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis. PLoS Biology. 2018 Dec 28;16(12):e2005907.
Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Saur D, Kalluri R. Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program. EMBO Molecular Medicine. 2018 Aug 17. pii: e9085.
Chen Y, Wang S, Lu X, Zhang H, Fu Y, Luo Y. Cholesterol sequestration by nystatin enhances the uptake and activity of endostatin in endothelium via regulating distinct endocytic pathways. Blood. 2011;117:6392-403.
Chen Y, Liu G, Guo L, Wang H, Fu Y, Luo Y. Enhancement of tumor uptake and therapeutic efficacy of EGFR-targeted antibody cetuximab and antibody-drug conjugates by cholesterol sequestration. International Journal of Cancer. 2015;136(1):182-194.
Liu G, Chen Y*, Guo L, Qi F, Wang H, Fu Y, Luo Y. Specific chemotherapeutic agents induce metastatic behaviour through stromal- and tumour-derived cytokine and angiogenic factor signalling. Journal of Pathology. 2015:237(2):190-202. (*Co-first author)
Chen Y, Du Y, Wu F, Fu Y, Li Z, Luo Y. Phase I trial of PEGylated recombinant human endostatin (M2ES) plus gemcitabine in advanced pancreatic cancer. Molecular and Clinical Oncology. 2014;2(4):586-590.
Tang M, Chen Y, Li B, Sugimoto H, Yang S, Yang C, LeBleu VS, McAndrews KM, Kalluri R. Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis. FASEB Journal. 2021 May 35 (5);e21557.
McAndrews KM, Chen Y, Kalluri R. Stromal Cells Exhibit Prevalent Genetic Aberrations in Colorectal Cancer. Cancer Cell. 2020 Dec 14;38(6):774-775.
Guo L, Chen Y, He T, Qi F, Liu G, Fu Y, Rao C, Wang J, Luo Y. Nuclear-translocated endostatin downregulates hypoxia inducible factor-1α activation through interfering with Zn(II) homeostasis. Molecular Medicine Reports. 2015 May;11(5):3473-80.
Wang H, Chen Y, Lu XA, Liu G, Fu Y, Luo Y. Endostatin Prevents Dietary-Induced Obesity by Inhibiting Adipogenesis and Angiogenesis. Diabetes. 2015 Jan 20. pii: db140528.
Yang J, Song X, Chen Y, Lu X, Fu Y, Luo Y. PLCγ1-PKCγ signaling mediated Hsp90α plasma membrane translocation facilitates tumor metastasis. Traffic. 2014;15(8):861-878.
Guo L, Geng X, Chen Y, Qi F, Liu L, Miao Y, Lin Z, Fu Y, Li B, Luo Y. Pre-clinical pharmacokinetics and safety study of M2ES, a PEGylated recombinant human endostatin, in rhesus monkeys. Regulatory Toxicology and Pharmacology. 2014;69(3):512-523.
Zhao H, Huang Y, Xue C, Chen Y, Hou X, Guo Y, Zhao L, Hu Zh, Huang Y, Luo Y, Zhang L. Prognostic significance of the combined score of endothelial expression of nucleolin and CD31 in surgically resected non-small cell lung cancer. PLoS One. 2013;8(1):e54674.
Ding Y, Song N, Liu C, He T, Zhuo W, He X, Chen Y, Song X, Fu Y, Luo Y. Heat Shock Cognate 70 Regulates the Translocation and Angiogenic Function of Nucleolin. Arterioscler Thromb Vasc Biol. 2012;32(9):e126-34.
Song N, Ding Y, Zhuo W, He T, Fu Z, Chen Y, Song X, Fu Y, Luo Y. The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells. Angiogenesis. 2012;15(4):697-711.
Zhuo W, Chen Y, Song X, Luo Y. Endostatin specifically targets both tumor blood vessels and lymphatic vessels. Frontiers of medicine. 2011;5:336-40.
Fu Y, Chen Y, Luo X, Liang Y, Shi H, Gao L, Zhan S, Zhou D, Luo Y. The heparin binding motif of endostatin mediates its interaction with receptor nucleolin. Biochemistry. 2009;48:11655-63.
Yu Q, Chen Y, Kou C, Liu S, Yu Y. Relationship between HLA class II gene polymorphism and schizophrenia. Journal of Jilin University (Medicine Edition). 2007;33(2):306-309.
Zhang H, Ju G, Wei J, Hu Y, Liu L, Xu Q, Chen Y, Sun Z, Liu S, Yu Y, Guo Y, Shen Y. A combined effect of the KPNA3 and KPNB3 genes on susceptibility to schizophrenia. Neuroscience Letters. 2006;402:173-175.