Selected Publications
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Garrity R, Arora N, Haque MA, Weis D, Trinh RT, Neerukonda SV, Kumari S, Cortez I, Ubogu EE, Mahalingam R, Tavares-Ferreira D, Price TJ, Kavelaars A, Heijnen CJ, Shepherd AJ. Fibroblast-derived PI16 sustains inflammatory pain via regulation of CD206(+) myeloid cells. Brain Behav Immun. 2023 Aug;112:220-234. doi: 10.1016/j.bbi.2023.06.011. Epub 2023 Jun 12. PubMed PMID: 37315702.
McIlvried LA, Del Rosario JS, Pullen MY, Wangzhou A, Sheahan TD, Shepherd AJ, Slivicki RA, Lemen JA, Price TJ, Copits BA, Gereau RW. Intrinsic homeostatic plasticity in mouse and human sensory neurons. bioRxiv. 2023 Jun 14;. doi: 10.1101/2023.06.13.544829. PubMed PMID: 37398430; PubMed Central PMCID: PMC10312743.
Robilotto GL, Mohapatra DP, Shepherd AJ, Mickle AD. Role of Src kinase in regulating protein kinase C mediated phosphorylation of TRPV1. Eur J Pain. 2022 Oct;26(9):1967-1978. doi: 10.1002/ejp.2017. Epub 2022 Aug 4. PubMed PMID: 35900227; PubMed Central PMCID: PMC9483845.
Balogh M, Zhang J, Gaffney CM, Kalakuntla N, Nguyen NT, Trinh RT, Aguilar C, Pham HV, Milutinovic B, Nichols JM, Mahalingam R, Shepherd AJ. Sensory neuron dysfunction in orthotopic mouse models of colon cancer. J Neuroinflammation. 2022 Aug 12;19(1):204. doi: 10.1186/s12974-022-02566-z. PubMed PMID: 35962398; PubMed Central PMCID: PMC9375288.
Gaffney CM, Muwanga G, Shen H, Tawfik VL, Shepherd AJ. Mechanical conflict-avoidance assay to measure pain behavior in mice. J Vis Exp. 2022 Feb 18;(180). doi: 10.3791/63454. PubMed PMID: 35253785; PubMed Central PMCID: PMC9058981.
Balogh M, Janjic JM, Shepherd AJ. Targeting neuroimmune interactions in diabetic neuropathy with nanomedicine. Antioxid Redox Signal. 2022 Jan;36(1-3):122-143. doi: 10.1089/ars.2021.0123. PubMed PMID: 34416821; PubMed Central PMCID: PMC8823248.
Nichols JM, Crelli CV, Liu L, Pham HV, Janjic JM, Shepherd AJ. Tracking macrophages in diabetic neuropathy with two-color nanoemulsions for near-infrared fluorescent imaging and microscopy. J Neuroinflammation. 2021 Dec 23;18(1):299. doi: 10.1186/s12974-021-02365-y. PubMed PMID: 34949179; PubMed Central PMCID: PMC8697472.
Balogh M, Aguilar C, Nguyen NT, Shepherd AJ. Angiotensin receptors and neuropathic pain. Pain Rep. 2021;6(1):e869. doi: 10.1097/PR9.0000000000000869. eCollection 2021. Review. PubMed PMID: 33981922; PubMed Central PMCID: PMC8108581.
Du KN, Shepherd AJ, Ma IV, Roldan CJ, Amit M, Feng LMS, Desai S, Cata JP. Lack of association between angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and pain improvement in patients with oral cancer. Ecancermedicalscience. 2020;14:1121. doi: 10.3332/ecancer.2020.1121. eCollection 2020. Review. PubMed PMID: 33209112; PubMed Central PMCID: PMC7652423.
English K, Shepherd A, Uzor NE, Trinh R, Kavelaars A, Heijnen CJ. Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer. Acta Neuropathol Commun. 2020 Mar 20;8(1):36. doi: 10.1186/s40478-020-00897-7. PubMed PMID: 32197663; PubMed Central PMCID: PMC7082981.
Shepherd AJ, Mohapatra DP. Attenuation of unevoked mechanical and cold pain hypersensitivities associated with experimental neuropathy in mice by angiotensin II type-2 receptor antagonism. Anesth Analg. 2019 Jun;128(6):e84-e87. doi: 10.1213/ANE.0000000000003857. PubMed PMID: 31094778; PubMed Central PMCID: PMC6652216.
Warwick CA, Shutov LP, Shepherd AJ, Mohapatra DP, Usachev YM. Mechanisms underlying mechanical sensitization induced by complement C5a: the roles of macrophages, TRPV1, and calcitonin gene-related peptide receptors. Pain. 2019 Mar;160(3):702-711. doi: 10.1097/j.pain.0000000000001449. PubMed PMID: 30507785; PubMed Central PMCID: PMC6377341.
Shepherd AJ, Mickle AD, McIlvried LA, Gereau RW 4th, Mohapatra DP. Parathyroid hormone-related peptide activates and modulates TRPV1 channel in human DRG neurons. Eur J Pain. 2018 Oct;22(9):1685-1690. doi: 10.1002/ejp.1251. Epub 2018 Jun 11. PubMed PMID: 29797679.
Shepherd AJ, Mickle AD, Golden JP, Mack MR, Halabi CM, de Kloet AD, Samineni VK, Kim BS, Krause EG, Gereau RW 4th, Mohapatra DP. Macrophage angiotensin II type 2 receptor triggers neuropathic pain. Proc Natl Acad Sci U S A. 2018 Aug 21;115(34):E8057-E8066. doi: 10.1073/pnas.1721815115. Epub 2018 Aug 6. PubMed PMID: 30082378; PubMed Central PMCID: PMC6112686.