Research

Photoacoustic Assessment of RF Ablation Lesions

RF ablation lesion assessment with multi wavelength photo acoustic imaging.

A: Single-wavelength photoacoustic image (710 nm) overlaying ultrasound image with ablated and nonablated regions of interest (ROIs).

C: Tissue characterization map (TCM).

Photoacoustic-Ultrasonic Imaging of Brachytherapy Seeds

US B-mode (A), PA (B), and combined PAUS (C) images of a seed embedded in a bovine prostate sample in the long-axis orientation.

PA image was acquired at 870 nm and is displayed with 35-dB dynamic range; B-mode image is displayed with 55-dB range.

PA Thermography of Photothermal Therapy

Photoacoustic imaging of Dox release in vivo following intratumoral injection of Dox@PEG-HAuNS and treatment with a 6-W surface laser. (A) B-mode of tumor xenographs, (B) photoacoustic (PA) image of tumor injected with Dox@PEG-HAuNS, and (C) PAUS image of tumor. (D) Plot of PA signal amplitude over time. (E) PA signal increased linearly with temperature. (F) Fit for conversion of PA signal to temperature (E).

Development of a Transrectal Photoacoustic-Ultrasonic Imaging Probe

A SolidWorks rendering (left) and the photograph of the machined prototype (right) transrectal probe.

The probe is outfit with seven optical fibers to allow for >30 mJ/pulse of NIR irradiation.

Acoustic Radiation Force-based Shear Wave Tissue Elasticity Imaging

Displacement images at four specific times (1, 5, 13, and 21 ms for images A through D, respectively) following ARFI excitation in the myocardium.

The right-most edge of the displacement profile in each image shows a shear wavefront probating left to right through time.

Multi-wavelength PA Imaging of Targeted Nanoparticles

PAUS image (A) acquired with Vevo LAZR platform of a subcutaneous PC3 human prostate cancer tumor injected with targeted gold nanorods (AuNRs).

Multiwavelength photoacoustic acquisition (B) and spectrum (C) of AuNRs.

PA images (Endra Nexus 128) of targeted AuNRs accumulating in PC3 tumor.