Publications

McCarty, J. H. (2020) alpahVbeta8 Integrin Adhesion and Signaling Pathways in Development, Physiology and Disease, Journal of Cell Science, 15;133: jcs239434. PMID: 32540905.

Morales, J. E., De, A., Chen, Z., Miller, A., and McCarty, J. H. (2021) Mlc1-Expressing Perivascular Astrocytes Promote Integrity of the Blood-Brain Barrier, Journal of Neuroscience, 42:1406-1416. PMID: 34965971

De, A., Chen, Z., Morales, J. E., Sebastian, S., and McCarty J. H. (2022) The Beta-8 Integrin Cytoplasmic Domain Activates Extracellular Matrix Adhesion During Brain Neurovascular Development, Development, 149:dev200472. PMID: 35217866

Yosef, N., Xi, Y., and McCarty, J. H. (2020) Isolation and Transcriptional Characterization of Mouse Perivascular Astrocytes, PLoS One, 15(10):e0240035. PMID: 33031376

Lattier, J. M., De, A., Chen, Z., Morales, J. E., Lang, F. F., Huse, J. T., and McCarty J. H. (2020) MLC1 Promotes Glioblastoma Cell Invasion in the Brain Microenvironment, Oncogene, 39: 7253-7264. PMID: 33040087

Chen, Z., Morales, J. E., Avci, N., Guerrero, P. A., Rao, G., Seo, J. H., and McCarty, J. H. (2020) The Vascular Endothelial Cell-Expressed Prion Protein Doppel Promotes Angiogenesis and Blood-Brain Barrier Development. Development, 147(18):dev193094. PMID: 32895288

Morales, J. E., De, A., Chen, Z., Miller, A., and McCarty, J. H. (2021) Mlc1-Expressing Perivascular Astrocytes Promote Integrity of the Blood-Brain Barrier, Journal of Neuroscience, 42:1406-1416. PMID: 34965971

De, A., Chen, Z., Morales, J. E., Sebastian, S., and McCarty, J. H. (2021) The beta8 Integrin Cytoplasmic Domain Activates Extracellular Matrix Adhesion During Brain Neurovascular Development, Development, 149;dev200472. PMID: 35217866 

Tiwary, S., Morales, J. E., Kwiatkowski, S. C., Lang, F. F., Rao, G., and McCarty J. H. (2018) Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a, Scientific Reports, 8:8267.

Toutounchian, J. J., Morales, J. E., Lattier, J. M., and McCarty, J. H. (2017) Selective Expression of EGFP in Mouse Perivascular Astrocytes by Modification of the Mlc1 Gene using T2A-Based Ribosome Skipping., Genesis, in press. *Cover article.

Guerrero, P. A., Tchaicha, J. H., Chen, Z., Wang, Q., Sulman, E. P., McCarty, N., Fuller, G., Lang, F. F., Rao, G., and McCarty, J. H. (2017) Glioblastoma Stem Cells Exploit the avb8 Integrin-TGFb1 Signaling Axis to Drive Tumor Initiation and Progression, Oncogene, in press.

Kwiatkowski, S. C., Hirota, S., Morales, J. E., Aghi, M., and McCarty, J. H. (2017) Neuropilin-1 Promotes TGFb Receptor Internalization and Signaling to Drive Glioblastoma Growth and Recurrence after Anti-Angiogenic Therapy, PLoS One, 12(9): e0185065.

Cheerathodi, M., Gul, N. A., Lee, H. S., Morales, J. E., Tang, L-K., Popp, J., Lang, F. F., Rivera, G. M. and McCarty, J. H. (2016) The Cytoskeletal Adaptor Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma, Molecular Cancer Research, 14: 1277-1287.

Lee, H. S., Cheerathodi, M., Chaki, S. L., Reyes, S. B., Zheng, Y., DerMardirossian, C., Lu, Z., Lacy-Hulbert, A., Rivera, G. M. and McCarty, J. H. (2015) A Signaling Unit Comprised of b8 Integrin and PTP-PEST Regulates Spatiotemporal Patterns of RhoGDI1 Activation in Migrating Cells, Molecular and Cellular Biology, 35: 1401-1413. PMCID: PMC4372704, *Cover article.

Savar, A., Acin, S., El Sawy, T., Mejia, O., Esmaeli, B., El-Naggar, A., Lacy-Hulbert, A., McCarty, J. H., and Caulin, C. (2014) Loss of p53 and av Integrin Cooperate to Induce Head and Neck Squamous Cell Carcinomas in Mice, Oncogene, in press.

McCarty, J. H. (2013) Glioblastoma Resistance to Anti-VEGF Therapy: Has the Challenge Been MET? Clinical Cancer Research, 19:1631-3.

Narayanan, A. S., Reyes, S. B., Um, K., McCarty, J. H., and Tolias, K. F. (2013) The Rac-GAP Bcr is a Regulator of the Par Complex that Controls Astrocyte Polarity. Molecular Biology of the Cell, 24: 3857-68.

Reyes, S. B., Narayanan, A. S., Tchaicha, J. H., Shin, H. S., Lang, F. F., Aldape, K. D., Tolias, K. F., and McCarty, J. H. (2013) avb8 Integrin Associates with RhoGDI1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion. Molecular Biology of the Cell, 4: 474-482.

Allinson, K., Lee, H. S., Fruttiger, M., McCarty, J. H., and Arthur, H. (2012) Endothelial Expression of TGFb Type II Receptor is Required to Maintain Vascular Integrity during Post-natal Development of the Central Nervous System. PLoS One, e39336.

Hirota, S., Liu, Q., Lee, H. S., Hossain, M. G., Lacy-Hulbert, A., and McCarty, J. H. (2011) The Astrocyte-Expressed Integrin avb8 Governs Blood Vessel Sprouting in the Developing Retina. Development, 23: 5157-5166.

Tchaicha, J. H., Reyes, S. B., Shin, J., Hossain, M. G., Lang, F. F., and McCarty, J. H. (2011) Glioblastoma Angiogenesis and Tumor Cell Invasiveness are Differentially Regulated by b8 Integrin. Cancer Research, 71: 6371-6381.

Jung, Y., Kissil, J. L., and McCarty, J. H. (2011) b8 Integrin and Band 4.1B Cooperatively Regulate Morphogenesis of the Embryonic Heart. Developmental Dynamics, 240: 271–277.

Nguyen, H. L., Park, S. O., Shin, J. K., McCarty, J. H.*, and Oh, S. P.* (2011) TGFb Signaling in Endothelial Cells, but not Neuroepithelial Cells, Controls Cerebral Vascular Development. Laboratory Investigation, 91: 1554-1563. *co-corresponding authors.

Mobley, A. K. and McCarty, J. H. (2011) b8 Integrin is Essential for Neuroblast Migration in the Rostral Migratory Stream. Glia, 59: 1579-1587.

Tchaicha, J. H., Mobley, A. K., Hossain, M. G., Aldape, K., and McCarty, J. H. (2010) A Mosaic Mouse Model of Astrocytoma Identifies avb8 Integrin as a Negative Regulator of Tumor Angiogenesis. Oncogene, 29: 4460-4472.

Mobley, A. K., Tchaicha, J. H., Shin, J., Hossain, M. G., and McCarty, J.H. (2009) b8 Integrin Regulates Neurogenesis and Neurovascular Homeostasis in the Adult Brain. Journal of Cell Science, 122: 1842-1851.

McCarty, J. H., Lacy-Hulbert, A., Charest, A., Crowley, D., Housman, D., Savill, J., Roes, J., and Hynes, R. O. (2005) Selective Ablation of av Integrins in the Central Nervous System Leads to Cerebral Hemorrhage, Seizures, Axonal Degeneration and Premature Death. Development, 132: 165-176.

McCarty, J. H., Cook, A. A., and Hynes, R. O. (2005) An Interaction between avb8 Integrin and Band 4.1B via a Highly Conserved Region of the Band 4.1 C-Terminal Domain. Proceedings of the National Academy of Sciences, 102: 13479-83.