Shih-Han (Peggy) Lee, Ph.D.
Areas of Research
- Gene Expression Research
- Transcription Research
- RNA Processing
- Alternative Cleavage and Polyadenylation Research
Welcome to the Lee Laboratory at MD Anderson Cancer Center. We are a RNA and cancer biology lab. We use multi-disciplinary approaches to investigate the role of RNA processing, with a focus on alternative cleavage and polyadenylation in cancer onset and progression.
Altered RNA processing is widespread in cancer, yet our knowledge of how it contributes to cancer pathogenesis remains limited. Our lab aims to uncover aberrant RNA-processing events and define their functional consequences in driving tumor development and disease progression. In addition, we investigate molecular mechanisms that regulate the expression of alternative RNA isoforms. We hope to improve our understanding of the biological importance of transcriptomic alterations and provide novel strategies for cancer diagnosis, prognosis and therapeutic intervention.