The Huse Laboratory seeks to understand the molecular pathogenesis of primary brain tumors and brain metastases. We're particularly interested in how epigenetic and gene-regulatory mechanisms influence these disease processes.
The recent focus of our research has been on specific chromatin modifying alterations involved in the development of diffusely infiltrating gliomas. We're also studying how unique transcriptional signatures drive the process of brain metastasis. Finally, we are employing molecular profiling to refine brain tumor classification, and explore links with germline genetics and clinical outcome measures.
Jason T. Huse, M.D., Ph.D.
Associate Professor, Pathology
LSP9.4009, Unit 2951
Houston, TX 77030