Areas of Research
- Brain and CNS Tumor Research
- Chromatin Remodelers Research
- Chromatin Research
- Epigenetics Research
- Histone Modification Research
- Genomics Research
- Genome Stability Research
- Disease Pathology Research
The Huse Laboratory seeks to understand the molecular pathogenesis of primary brain tumors and brain metastases. We're particularly interested in how epigenetic and gene-regulatory mechanisms influence these disease processes.
The recent focus of our research has been on specific chromatin modifying alterations involved in the development of diffusely infiltrating gliomas. We're also studying how unique transcriptional signatures drive the process of brain metastasis. Finally, we are employing molecular profiling to refine brain tumor classification, and explore links with germline genetics and clinical outcome measures.
Meet the Team
Back row, left to right: Carla Danussi, Kazutaka Fukumura, Vladislav Sharin, Jason Huse, Sofie Gresser, Christian Alvarez, David Irvin, Ahsan Farooqi. Front row, left to right: Sharvari Dharmaiah, Hannah Roberts.
Join the Lab
Positions are available for motivated graduate students and postdoctoral fellows with wet and/or dry lab interests. Ongoing projects in the lab involve functional genomics/epigenomics, brain tumor mouse modeling, molecular pathology/genetics, and drug screening.