Selected Publications

Singh AK, Ruiz D, Pandey VK, Ur Rasheed MS, Turner DJL, Avery TD, Abell AD, Grace PM.

Targeted activation of Nrf2 at sites of oxidative stress reverses doxorubicin-induced cognitive impairments in mice. Opens a new window

Brain Behav Immun 129:547-556, 2025.

Fiore NT, Willcox KF, Grieco AR, Dayani D, Zuberi YA, Heijnen CJ, Grace PM.

Autoreactive IgG levels and Fc receptor γ subunit upregulation drive mechanical allodynia after nerve constriction or crush injury Opens a new window

bioRxiv [Preprint] 2025.03.22.644748, 2025.

Yousuf MS, Mancilla Moreno M, Woodall BJ, Thakur V, Li J, He L, Arjarapu R, Royer D, Zhang J, Chattopadhyay M, Grace PM, Price TJ.

Diroximel fumarate acts through Nrf2 to attenuate methylglyoxal-induced nociception in mice and decrease ISR activation in DRG neurons. Opens a new window

Diabetes 74(5):827-837, 2025.

Fiore NT, Willcox KF, Dayani D, Zuberi YA, Heijnen CJ, Grace PM.

Reducing IgG accumulation via neonatal Fc receptor (FcRn) blockade relieves neuropathic pain. Opens a new window

Brain Behav Immun 125:371-387, 2025.

Avery TD, Li J, Turner DJL, Rasheed MSU, Cherry FR, Stachura DL, Rivera-Escalera F, Ruiz DM, Lacagnina MJ, Gaffney CM, Aguilar C, Yu J, Wang Y, Xie H, Liang D, Shepherd AJ, Abell AD, Grace PM.

Site-specific drug release of monomethyl fumarate to treat oxidative stress disorders. Opens a new window

Nat Biotechnol 10.1038/s41587-024-02460-4, 2024.

Lacagnina MJ, Willcox KF, Boukelmoune N, Bavencoffe A, Sankaranarayanan I, Barratt DT, Zuberi YA, Dayani D, Chavez MV, Lu JT, Farinotti AB, Shiers S, Barry AM, Mwirigi JM, Tavares-Ferreira D, Funk GA, Cervantes AM, Svensson CI, Walters ET, Hutchinson MR, Heijnen CJ, Price TJ, Fiore NT, Grace PM.

B cells drive neuropathic pain-related behaviors in mice through IgG-Fc gamma receptor signaling. Opens a new window

Sci Transl Med 16(766):eadj1277, 2024.

Cazuza RA, Zagrai SM, Grieco AR, Avery TD, Abell AD, Wey HY, Loggia ML, Grace PM.

18 kDa Translocator protein (TSPO) is upregulated in rat brain after peripheral nerve injury and downregulated by diroximel fumarate. Opens a new window

Brain Behav Immun 123:11-27, 2024.

Das AC, Nichols JM, Crelli CV, Liu L, Vichare R, Pham HV, Gaffney CM, Cherry FR, Grace PM, Shepherd AJ, Janjic JM.

Injectable, reversibly thermoresponsive captopril-laden hydrogel for the local treatment of sensory loss in diabetic neuropathy. Opens a new window

Sci Rep 14(1):18978, 2024.

Green-Fulgham SM, Lacagnina MJ, Willcox KF, Li J, Harland ME, Ciena AP, Rocha IRC, Ball JB, Dreher RA, Zuberi YA, Dragavon JM, Chacur M, Maier SF, Watkins LR, Grace PM.

Voluntary wheel running prevents formation of membrane attack complexes and myelin degradation after peripheral nerve injury. Opens a new window

Brain Behav Immun 115:419-431, 2023.

Green-Fulgham SM, Ball JB, Kwilasz AJ, Harland ME, Frank MG, Dragavon JM, Grace PM, Watkins LR.

Interleukin-1beta and inflammasome expression in spinal cord following chronic constriction injury in male and female rats. Opens a new window

Brain Behav Immun 115:157-168, 2023.

Mustafa S, Bajic JE, Barry B, Evans S, Siemens KR, Hutchinson MR, Grace PM.

One immune system plays many parts: the dynamic role of the immune system in chronic pain and opioid pharmacology. Opens a new window

Neuropharmacology 228:109459, 2023.

Li J, Stratton HJ, Lorca SA, Grace PM, Khanna R.

Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats. Opens a new window

Channels (Austin) 16(1):1-8, 2022.

Zhang J, Junigan JM, Trinh R, Kavelaars A, Heijnen CJ, Grace PM.

HDAC6 inhibition reverses cisplatin-induced mechanical hypersensitivity via tonic delta opioid receptor signaling. Opens a new window

J Neurosci 42(42):7862-7874, 2022.

Green-Fulgham SM, Harland ME, Ball JB, Li J, Lacagnina MJ, D'Angelo H, Dreher RA, Willcox KF, Lorca SA, Kwilasz AJ, Maier SF, Watkins LR, Grace PM.

Preconditioning by voluntary wheel running attenuates later neuropathic pain via nuclear factor E2-related factor 2 antioxidant signaling in rats. Opens a new window

Pain 163(10):1939-1951, 2022.

Green-Fulgham SM, Ball JB, Maier SF, Rice KC, Watkins LR, Grace PM.

Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists. Opens a new window

J Neurosci Res 100(1):265-277, 2022.

Cata JP, Patiño M, Lacagnina MJ, Li J, Gorur A, Agudelo-Jimenez R, Wei B, Hagberg CA, Dougherty PM, Shureiqi I, Yang P, Grace PM.

A rat model to investigate quality of recovery after abdominal surgery. Opens a new window

Pain Rep 6(2):e943, 2021.

Hoogendoorn A, Avery TD, Li J, Bursill C, Abell A, Grace PM.

Emerging therapeutic applications for fumarates. Opens a new window

Trends Pharmacol Sci 42(4):239-254, 2021.

Lacagnina MJ, Heijnen CJ, Watkins LR, Grace PM.

Autoimmune regulation of chronic pain. Opens a new window

Pain Rep 6(1):e905, 2021.

Grace PM, Tawfik VL, Svensson CI, Burton MD, Loggia ML, Hutchinson MR.

The neuroimmunology of chronic pain: from rodents to humans. Opens a new window

J Neurosci 41(5):855-865, 2021.

Muscat SM, Deems NP, D'Angelo H, Kitt MM, Grace PM, Andersen ND, Silverman SN, Rice KC, Watkins LR, Maier SF, Barrientos RM.

Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats. Opens a new window

Neurobiol Aging 98:214-224, 2021.