Vidya Gopalakrishnan, Ph.D.
- Departments, Labs and Institutes
- Gopalakrishnan Laboratory
Areas of Research
- Pediatric Research
- Brain and CNS Tumor Research
- Chromatin Remodelers Research
- Epigenetics Research
The overall goal of research in the Gopalakrishnan Laboratory is to understand how pediatric brain tumors develop and to translate this information for therapeutic purposes.
Despite the rarity of childhood cancers, they are the leading cause of death from disease among children in the United States. A central challenge to improving long-term survival in pediatric cancer patients is an extremely limited spectrum of therapeutics that are effective in the setting of recurrent or metastatic tumors. High-throughput genomic studies have underscored the scarcity of mutations in pediatric tumors and also highlighted the need to evaluate changes in chromatin structure, post-translational modifications on proteins and a dysfunctional tumor microenvironment as drivers of childhood cancers. The advantage to the study of epigenetic, proteomic or immune mis-regulation in cancers is that these are potentially reversible and can be therapeutically targeted. Indeed, a number of epigenetic, kinase and immune modulators are in clinical trials for adult cancers and can be readily leveraged in a pediatric setting. Thus, the overall goal of research in my lab is to understand how pediatric brain tumors develop and to translate this information for therapeutic purposes.
Cancer Prevention Research Institute of Texas (CPRIT)
National Institutes of Health (NIH)
American Cancer Society (ACS)
Addis Faith Foundation
Rally Foundation for Childhood Cancers
Meet the Team
Dr. Gopalakrishnan's lab is made up of a team of researchers with distinct specialties and various areas of expertise.
Transcriptional repressor REST drives lineage-stage specific histone H3-lysine-9 methylation and Ptch1 loss of heterozygosity and Akt hyperactivity in medulloblastoma.
Dobson THW, Tao RH, Swaminathan J, Maegawa S, Shaik S, Bravo-Alegria J, Sharma A, Kennis B, Yang Y, Callegari K, Haltom A, Talyor P, Kogiso M, Qi L, Khatua S, Goldman S, Lulla R, Fangusaro J, MacDonald T, Li XL, Hawkins C, Rajaram V, Gopalakrishnan V
Pre-clinical models of pediatric brain tumors--forging ahead
Dobson THW and Gopalakrishnan V
MLL4 is required to maintain broad range H3K4me3 peaks and super-enhancers at tumor suppressor genes
Dhar S, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe R, Chen K and Lee MG
REST upregulates gremlin to modulate diffuse intrinsic pontine glioma vasculature
Shaik S*, Kennis B*, Fangusaro J, Lulla R, Rajaram V, Goldman S, Nazarian J and Gopalakrishnan V
The ubiquitin proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities
Zaky W, Manton C, Miller C, Khatua S, Gopalakrishnan V and Chandra C
Targeting P-selectin blocks neuroblastoma growth
Nolo R, Herbrich S, Kannan S, Rao A, Zweidler-McKay P and Gopalakrishnan V
Molecular Cancer Research
Regulation of USP37 expression by REST-associated G9a-dependent histone methylation
Dobson THW, Hatcher RJ, Swaminathan J, Das CM, Shaik S, Tao RH, Milite C, Castellano S, Taylor PH, Sbardella G, Gopalakrishnan V
Methods in Molecular Biology
In vivo (19) F-magnetic resonance imaging of adoptively transferred NK cells
Somanchi SS, Kennis BA, Gopalakrishnan V, Lee DA, Bankson JA
Cell Communication and Signaling
Pharmacological Inhibition of LSD1 blocks REST-dependent medulloblastoma cell migration.
Callegari K, Maegawa S, Bravo-Alegria J and Gopalakrishnan V