Andrew Gladden, Ph.D.
Area of Research
- Genetics Research
The main focus of our research is to gain insight into the role of cell adhesion pathways in the development and homeostasis of tissues and organs. We are also interested in understanding how the disruption of specific adhesion and signaling pathways contributes to tumor initiation and progression to metastasis. Our laboratory utilizes a number of different approaches to address this overarching goal including, genetic mouse models, cell culture studies, organotypic cultures and biochemistry.
Cells must be able to sense neighboring cells and the surrounding environment to organize into tissues and organs in the mammalian body. How cells sense and communicate with adjacent cells is a fundamental question being asked in the Gladden Laboratory. In particular, we study how cell adhesion and cell polarity are intertwined in normal tissue development and how these pathways are altered in diseases such as cancer.