Most Significant Publications

Liebau RC, Waters C, Ahmed A, Soni RK, Gautier J. UVSSA facilitates transcription-coupled repair of DNA interstrand crosslinks. DNA Repair (Amst). 2024 Nov;143:103771. PMID: 39383571.

Min J, Zhao J, Zagelbaum J, Lee J, Takahashi S, Cummings P, Schooley A, Dekker J, Gottesman ME, Rabadan R, Gautier J. Mechanisms of insertions at a DNA double-strand break. Mol Cell. 2023 Jul 20;83(14):2434-2448.e7. PMID: 37402370. 

Zagelbaum J, Schooley A, Zhao J, Schrank BR, Callen E, Zha S, Gottesman ME, Nussenzweig A, Rabadan R, Dekker J, Gautier J. Multiscale reorganization of the genome following DNA damage facilitates chromosome translocations via nuclear actin polymerization. Nat Struct Mol Biol. 2023 Jan;30(1):99-106. doi: 10.1038/s41594-022-00893-6. PMID: 36564591. 

Prakash R, Sandoval T, Morati F, Zagelbaum JA, Lim PX, White T, Taylor B, Wang R, Desclos ECB, Sullivan MR, Rein HL, Bernstein KA, Krawczyk PM, Gautier J, Modesti M, Vanoli F, Jasin M. Distinct pathways of homologous recombination controlled by the SWS1-SWSAP1-SPIDR complex. Nat Commun. 2021 Jul 12;12(1):4255. PMID: 34253720.

Tao Y, Aparicio T, Li M, Leong KW, Zha S, Gautier J. Inhibition of DNA replication initiation by silver nanoclusters. Nucleic Acids Res. 2021 May 21;49(9):5074-5083. PMID: 33905520.

Sato M, Liebau RC, Liu Z, Liu L, Rabadan R, Gautier J. The UVSSA complex alleviates MYC-driven transcription stress. J Cell Biol. 2021 Feb 1;220(2):e201807163. PMID: 33404608.

Tao Y, Li M, Liu X, Leong KW, Gautier J*, Zha S*. Dual-Color Plasmonic Nanosensor for Radiation Dosimetry. ACS Appl Mater Interfaces. 2020 May 20;12(20):22499-22506. PMID: 32337977. (*equal contribution).

Schrank BR, Aparicio T, Li Y, Chang W, Chait BT, Gundersen GG, Gottesman ME, Gautier J. Nuclear ARP2/3 drives DNA break clustering for homology-directed repair. Nature. 2018 Jul;559(7712):61-66. PMID: 29925947.

Kato N, Kawasoe Y, Williams H, Coates E, Roy U, Shi Y, Beese LS, Schärer OD, Yan H, Gottesman ME, Takahashi TS, Gautier J. Sensing and Processing of DNA Interstrand Crosslinks by the Mismatch Repair Pathway. Cell Rep. 2017 Oct 31;21(5):1375-1385. PMID: 29091773.

Aparicio T, Baer R, Gottesman M, Gautier J. MRN, CtIP, and BRCA1 mediate repair of topoisomerase II-DNA adducts. J Cell Biol. 2016 Feb 15;212(4):399-408. PMID: 26880199. 

Srinivasan SV, Dominguez-Sola D, Wang LC, Hyrien O, Gautier J. Cdc45 is a critical effector of myc-dependent DNA replication stress. Cell Rep. 2013 May 30;3(5):1629-39. PMID: 23643534.

Rozier L, Guo Y, Peterson S, Sato M, Baer R, Gautier J*, Mao Y*. The MRN-CtIP pathway is required for metaphase chromosome alignment. Mol Cell. 2013 Mar 28;49(6):1097-107. PMID: 23434370. (*co-corresponding authors).

Peterson SE, Li Y, Wu-Baer F, Chait BT, Baer R, Yan H, Gottesman ME, Gautier J. Activation of DSB processing requires phosphorylation of CtIP by ATR. Mol Cell. 2013 Feb 21;49(4):657-67. PMID: 23273981.

Williams HL, Gottesman ME, Gautier J. Replication-independent repair of DNA interstrand crosslinks. Mol Cell. 2012 Jul 13;47(1):140-7. PMID: 22658724.

Peterson SE, Li Y, Chait BT, Gottesman ME, Baer R, Gautier J. Cdk1 uncouples CtIP-dependent resection and Rad51 filament formation during M-phase double-strand break repair. J Cell Biol. 2011 Sep 5;194(5):705-20. PMID: 21893598.

Kurth I, Gautier J. Origin-dependent initiation of DNA replication within telomeric sequences. Nucleic Acids Res. 2010 Jan;38(2):467-76. PMID: 19906732.

Di Virgilio M, Ying CY, Gautier J. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair (Amst). 2009 Nov 2;8(11):1311-20. PMID: 19709933.

Ben-Yehoyada M, Wang LC, Kozekov ID, Rizzo CJ, Gottesman ME, Gautier J. Checkpoint signaling from a single DNA interstrand crosslink. Mol Cell. 2009 Sep 11;35(5):704-15. PMID: 19748363.

Wang LC, Stone S, Hoatlin ME, Gautier J. Fanconi anemia proteins stabilize replication forks. DNA Repair (Amst). 2008 Dec 1;7(12):1973-81. PMID: 18786657.

Dupré A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, Kopelovich L, Jasin M, Baer R, Paull TT, Gautier J. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008 Feb;4(2):119-25. PMID: 18176557. Isolation of the first inhibitor of the Mre11 helicase.

Dominguez-Sola D, Ying CY, Grandori C, Ruggiero L, Chen B, Li M, Galloway DA, Gu W, Gautier J, Dalla-Favera R. Non-transcriptional control of DNA replication by c-Myc. Nature. 2007 Jul 26;448(7152):445-51. PMID: 17597761.

Dupré A, Boyer-Chatenet L, Gautier J. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Struct Mol Biol. 2006 May;13(5):451-7. PMID: 16622404.

Ying CY, Gautier J. The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding. EMBO J. 2005 Dec 21;24(24):4334-44. PMID: 16369567.

Di Virgilio M, Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol. 2005 Dec 5;171(5):765-71. PMID: 16330708.

Yeo W, Gautier J. XNGNR1-dependent neurogenesis mediates early neural cell death. Mech Dev. 2005 May;122(5):635-44. PMID: 15817221.

Shechter D, Ying CY, Gautier J. DNA unwinding is an Mcm complex-dependent and ATP hydrolysis-dependent process. J Biol Chem. 2004 Oct 29;279(44):45586-93. PMID: 15326181

Shechter D, Costanzo V, Gautier J. ATR and ATM regulate the timing of DNA replication origin firing. Nat Cell Biol. 2004 Jul;6(7):648-55. PMID: 15220931.

Costanzo V, Paull T, Gottesman M, Gautier J. Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLoS Biol. 2004 May;2(5):E110. PMID: 15138496.

Yeo W, Gautier J. A role for programmed cell death during early neurogenesis in xenopus. Dev Biol. 2003 Aug 1;260(1):31-45. PMID: 12885553.

Costanzo V, Shechter D, Lupardus PJ, Cimprich KA, Gottesman M, Gautier J. An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication. Mol Cell. 2003 Jan;11(1):203-13. PMID: 12535533.

Costanzo V, Robertson K, Bibikova M, Kim E, Grieco D, Gottesman M, Carroll D, Gautier J. Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication. Mol Cell. 2001 Jul;8(1):137-47. PMID: 11511367.

Costanzo V, Robertson K, Ying CY, Kim E, Avvedimento E, Gottesman M, Grieco D, Gautier J. Reconstitution of an ATM-dependent checkpoint that inhibits chromosomal DNA replication following DNA damage. Mol Cell. 2000 Sep;6(3):649-59. PMID: 11030344.

Shechter DF, Ying CY, Gautier J. The intrinsic DNA helicase activity of Methanobacterium thermoautotrophicum delta H minichromosome maintenance protein. J Biol Chem. 2000 May 19;275(20):15049-59. PMID: 10747908.

Bao J, Talmage DA, Role LW, Gautier J. Regulation of neurogenesis by interactions between HEN1 and neuronal LMO proteins. Development. 2000 Jan;127(2):425-35. PMID: 10603358.

Hensey C, Gautier J. Programmed cell death during Xenopus development: a spatio-temporal analysis. Dev Biol. 1998 Nov 1;203(1):36-48. PMID: 9806771.

Hensey C, Gautier J. A developmental timer that regulates apoptosis at the onset of gastrulation. Mech Dev. 1997 Dec;69(1-2):183-95. PMID: 9486540.

Hendrickson M, Madine M, Dalton S, Gautier J. (1996) Phosphorylation of MCM4 by the cdc2protein kinase inhibits the activity of the minichromosome maintenance complex. Proc Natl Acad Sci USA. 1996 Oct 29;93(22):122223-8. PMID: 8901561.

Gautier J, Solomon MJ, Booher RN, Bazan JF, Kirschner MW. cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2. Cell. 1991 Oct 4;67(1):197-211. PMID: 1913817.

Gautier J, Minshull J, Lohka M, Glotzer M, Hunt T, Maller JL. Cyclin is a component of maturation-promoting factor from Xenopus. Cell. 1990 Feb 9;60(3):487-94. PMID: 1967981.

Gautier J, Matsukawa T, Nurse P, Maller J. Dephosphorylation and activation of Xenopus p34cdc2 protein kinase during the cell cycle. Nature. 1989 Jun 22;339(6226):626-9. PMID: 2543932.

Gautier J, Norbury C, Lohka M, Nurse P, Maller J. Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+. Cell. 1988 Jul 29;54(3):433-9. PMID: 3293803.

Ahmed A, Kato N, Gautier J. Replication-Independent ICL Repair: From Chemotherapy to Cell Homeostasis. J Mol Biol. 2024 Jul 1;436(13):168618. PMID: 38763228 (Review).

Min J, Gautier J. Chromatin compartments at DNA double-stranded breaks. Cell Res. 2024 May;34(5):337-338. PMID: 38097773 (Research Highlight).

Zagelbaum J, Gautier J. Double-strand break repair and mis-repair in 3D. DNA Repair (Amst). 2023 Jan;121:103430. PMID: 36436496 (Review).

Aparicio Casado T, Gautier J. DNA Damage Response in Xenopus laevis Cell-Free Extracts. Methods Mol Biol. 2021;2267:103-144. PMID: 33786788. (Methods).

Schrank B, Gautier J. Assembling nuclear domains: Lessons from DNA repair. J Cell Biol. 2019 Aug 5;218(8):2444-2455. PMID: 31324649 (Review).

Dominguez-Sola D, Gautier J. MYC and the control of DNA replication. Cold Spring Harb Perspect Med. 2014 Jun 2;4(6):a014423. PMID: 24890833. (Review).

Symington LS, Gautier J. Double-strand break end resection and repair pathway choice. Annu Rev Genet. 2011;45:247-71. PMID: 21910633. (Review).

Shechter D, Gautier J. ATM and ATR check in on origins: a dynamic model for origin selection and activation. Cell Cycle. 2005 Feb;4(2):235-8. PMID: 15655372.

Shechter D, Costanzo V, Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):901-8. PMID: 15279775. (Review).