Publications
Eduful B, O'Byrne S, Temme L, Asquith CRM, Liang Y, Picado A, Pilotte J, Wells C, Zuercher WJ, Catta-Preta C, Ramos PZ, Santiago A, Counago R, Langendorf CG, Nay K, Oakhill JS, Pulliam TL, Lin C, Awad D, Willson TM, Frigo DE, Scott JW, and Drewry DH. Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem (Online ahead of print), 2021. PMID: 34264658.
Barton M, Frigo DE, Madak-Erdogan Z, Mauvais-Jarvis F, and Prossnitz ER. Steroid Hormones and Receptors in Health and Disease: A Research Conference Co-Organized by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH), May 25-27, 2021. FASEB J (In press), 2021.
Shatnawi A, Abu Rabe DI and Frigo DE. Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer. Adv Cancer Res 152:225-262, 2021. PMID: 34353439.
Lin C, Blessing AM, Pulliam TL, Shi Y, Wilkenfeld SR, Han JJ, Murray MM, Pham AH, Duong K, Brun SN, Shaw RJ, Ittmann MM, and Frigo DE. Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. Oncogene 40(9):1690-1705, 2021. PMID: 33531625.
Subramani E and Frigo DE. Mitochondria in Metabolic Syndrome, Reproduction and Transgenerational Inheritance—Ongoing Debates and Emerging Links. Endocrinology 162(1):bqaa182, 2021. PMID: 33275660.
Dahl HC, Kanchwala M, Thomas-Jardin SE, Sandhu A, Kanumuri P, Xing C, Lin C, Frigo DE and Delk NA. Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence. PLoS One 15(12):e0242970, 2020. PMID: 33326447.
Chen R, Liang X, Murray MM, Karasik E, Han JJ, Zhu M, Foster BA*, Frigo DE* and Wang G*. A simple quantitative PCR assay to determine TRAMP transgene zygosity. Prostate Cancer Prostatic Dis 24(2):358-361, 2021. PMID: 32895469.
Lin C, Salzillo TC, Bader DA, Wilkenfeld SR, Awad D, Pulliam TL, Dutta P, Pudakalakatti S, Titus M, McGuire SE, Bhattacharya PK and Frigo DE. Prostate Cancer Energetics and Biosynthesis. Adv Exp Med Biol 1210:185-237, 2019. PMID: 31900911.
Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM and Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4). Pii: E340, 2019. PMID: 30978984.
Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA and Bhattacharya P. Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Mol Imaging Biol [Epub ahead of print], 2018. PMID: 29748904.
Awad D, Pulliam TL, Lin C, Wilkenfeld SR and Frigo DE. Delineation of the androgen-regulated signaling pathways in prostate cancer facilitates the development of novel therapeutic approaches. Curr Opin Pharmacol 41:1-11, 2018. PMID: 29609138.
Yu G, Cheng CJ, Lin SC, Lee YC, Frigo DE, Yu-Lee LY, Gallick GE, Titus MA, Nutt LK and Lin SH. Calmodulin kinase II activation through organelle-derived acetyl-CoA promotes prostate cancer cell survival and migration in vitro and metastasis in vivo. Cancer Res 78(10):2490-2502, 2018. PMID: 29535221.
White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C and Frigo DE. GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocr Relat Cancer 25(4):453-469, 2018. PMID: 29431615.
Wilkenfeld SR, Lin C
White MA, Lin C, Rajapakshe K, Dong J, Shi Y, Tsouko E, Mukhopadhyay R, Jasso D, Dawood W, Coarfa C and Frigo DE. Glutamine Transporters are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer. Mol Cancer Res 15(8):1017-1028, 2017. PMID: 28507054.
Khan AS and Frigo DE. A Spatiotemporal Hypothesis for the Regulation, Role
Blessing AM, Rajapakshe K, Bollu LR, Shi Y, White MA, Pham AH, Lin C, Jonsson P, Cortes CJ, Cheung E, La Spada AR, Bast RC, Merchant FA, Coarfa C and Frigo DE. Transcriptional Regulation of Core Autophagy and Lysosomal Genes by the Androgen Receptor Promotes Prostate Cancer Progression. Autophagy 13(3):506-521, 2017. PMID: 27977328.
Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards D, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G and Sreekumar A. Inhibition of Hexosamine Biosynthetic Pathway Promotes Castration Resistant Prostate Cancer. Nat Commun 7;11612, 2016. PMID: 27194471.
Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat V, Bhowmik S, Gupta V, Arora K, Wu D, Tsouko E, Zhang Y, Maity S, Donti TR, Graham BH, Frigo DE, Coarfa C, Yotnda P, Putluri N, Lewis MT, Sreekumar A, Creighton CJ, Wong LJC and Kaipparettu BA. Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming to the Regulation of Oncogenic Properties in Triple Negative Breast Cancer. Cell Rep 14(9):2154-65, 2016. PMID: 26923594.
Klionsky DJ, Abdelmohsen K, Abe A, Frigo DE, Zughaier SM. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition). Autophagy 12(1):1-222, 2016. PMID: 26799652.
Blessing AM, Sathya G, Rajapakshe K, Sung YY, Bollu LR, Shi Y, Cheung E, Coarfa C, Chang JT, McDonnell DP and Frigo DE. Identification of a novel coregulator, SH3YL1, that interacts with the androgen receptor N-terminus. Mol Endocrinol 29(10):1426-39, 2015. PMID: 26305679.
Shafi AA, Putluri V, Arnold JM, Tsouko E, Maity S, Roberts JM, Coarfa C, Frigo DE, Putluri N, Sreekumar A and Weigel NL. Differential Regulation of Metabolic Pathways by Androgen Receptor (AR) and its Constitutively Active Splice Variant, AR-V7. Oncotarget 6(31):31997-2012, 2015. PMID: 26378018.
Gaur S, Wen Y, Song JH, Mangala LS, Blessing AM, Ivan C, Wu SY, Parikh NU, Varkaris A, Shi Y, Lopez-Berestein G, Frigo DE, Sood AK and Gallick GE. Chitosan Nanoparticle-Mediated Delivery of miRNA-34a Decreases Prostate Tumor Growth in the Bone and its Expression Induces Non-Canonical Autophagy. Oncotarget 6(30):29161-77, 2015. PMID: 26313360.
Tsouko E, Wang J, Frigo DE, Aydogdu E and Williams C. miR-200a inhibits migration of triple-negative breast cancer cells through direct repression of the EPHA2 oncogene. Carcinogenesis 36(9):1051-60, 2015. PMID: 26088362.
Popovics P*, Frigo DE*, Schally AV and Rick FG. Targeting the 5′-
*Co-first authors
Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, Sharpe MA, Xin L and Frigo DE. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis 3: e103, 2014. PMID: 24861463.
Tennakoon JB, Shi Y, Han JJ, Tsouko E, White MA, Burns AR, Zhang A, Xia X, Ilkayeva OR, Xin L, Ittmann MM, Rick EG, Schally AV and Frigo DE. Androgens Regulate Prostate Cancer Cell Growth via an AMPK-PGC-1a-Mediated Metabolic Switch. Oncogene 33(45):5251-61, 2014. PMID: 24186207.
Augello MA, Burd CJ, Birbe R, McNair C, Ertel A, Magee MS, Frigo DE, Wilder-Romans K, Shilkrut M, Han S, Jernigan DL, Dean JL, Fatatis A, McDonnell DP, Visakorpi T, Feng FY and Knudsen KE. Convergence of Oncogenic and Hormone Receptor Pathways Promotes Pro-Metastatic Phenotypes. J Clin Invest 123 (1): 493-508, 2013. PMID: 23257359.
Shi Y, Han JJ, Tennakoon JB, Mehta FF, Merchant FA, Burns AR, Howe MK, McDonnell DP and Frigo DE. Androgens Promote Prostate Cancer Cell Growth through Induction of Autophagy. Mol Endocrinol 27 (2): 280-95, 2013. PMID: 23250485. (Cover)
Bratton MR, Frigo DE, Segar HC, McLachlan JA, Wiese TE and Burow ME. The Organochlorine o,p’-DDT Plays a Role in Coactivator-Mediated MAPK Crosstalk in MCF-7 Breast Cancer Cells. Environ Health Perspect 120 (9): 1291-6, 2012. PMID: 22609851.
Frigo DE, Howe MK, Wittmann BM, Brunner AM, Cushman I, Wang Q, Brown M, Means AR and McDonnell DP. CaM
Frigo DE, Sherk AB, Wittmann BM, Norris JD, Wang Q, Joseph JD, Toner AP, Brown M, and McDonnell DP. Induction of Krüppel-like Factor 5 Expression by Androgens Results in Increased CXCR4-dependent Migration of Prostate Cancer Cells in vitro. Mol Endocrinol 23: 1385-1396, 2009. PMID: 19460858.
Frigo DE*, Bratton MR*, Vigh KA, Fan D, John A. McLachlan JA, and Burow ME. Phosphorylation and potentiation of the transcriptional coactivator p300 by p38 MAPK. Carcinogenesis 30 (1): 106-13, 2009. PMID: 18791200. *denotes co-first authors.
Sherk AB, Frigo DE, Schnackenberg CG, Bray JD, Laping NJ, Trizna W, Hammond M, Patterson JR, Thompson SK, Kazmin D, Norris JD, and McDonnell DP. Development of a Small Molecule Serum and Glucocorticoid-regulated Kinase 1 Antagonist and its Evaluation as a Prostate Cancer Therapeutic. Cancer Res 68 (18): 1-9, 2008. PMID: 18794135.
Frigo DE and McDonnell DP. Differential Effects of Prostate Cancer Therapeutics on Neuroendocrine Transdifferentiation. Mol Cancer Ther 7 (3): 659-69, 2008. PMID: 18347151.