Publications

Chen F, Li H, Wang Y, Tang X, Lin K, Li Q, Meng C, Shi W, Leo J, Liang X, Zhang J, Van V, Mahmud I, Wei B, Lorenzi PL, Raso MG, Aparicio A, Lu Y, Frigo DE, Gan B, Zhao D. CHD1 Loss Hijacks SREBP2-mediated Cholesterol Biosynthesis to Fuel SPOP-deficient Prostate Cancer and Confers Resistance to Castration. Nat Cancer. 2024 (in press).

Koutroumpakis E, Venkatesh N, Aparicio A, Song J, Panaretakis T, Deswal A, Logothetis CJ, Frigo DE, and Hahn AW. Leptin Levels are Associated with Coronary Artery Calcification in Patients with Advanced Prostate Cancer. Oncologist. 2024 Nov 18:oyae308. doi: 10.1093/oncolo/oyae308. [Epub ahead of print]. PMID: 39557398.

Venkatesh N, Tidwell RS, Yu Y, Aparicio A, Zurita AJ, Subudhi SK, Siddiqui BA, Mukhida SS, Gregg JR, Corn PG, Koutroumpakis E, McQuade JL, Frigo DE, Pilie PG, Huff CD, Logothetis CJ, and Hahn AW. Body composition in recurrent prostate cancer and the role of steroidogenic genotype. Endocr Relat Cancer. 2024 Sep 1;. doi: 10.1530/ERC-24-0195. [Epub ahead of print]. PMID: 39324992.

Hahn AW, Tidwell RS, Pilie PG, Yu Y, Liu J, Surasi DS, Titus M, Zhang J, Venkatesh N, Panaretakis T, Gregg JR, Zurita AJ, Siddiqui BA, Corn PG, Subudhi SK, Msaouel P, Koutroumpakis E, Huff CD, Aparicio A, McQuade JL, Frigo DE, and Logothetis CJ. Body composition as a determinant of the therapeutic index with androgen signaling inhibition. Prostate Cancer Prostatic Dis. 2024 Jul 17. doi: 10.1038/s41391-024-00870-8 (online ahead of print). PMID: 39019979.

Frigo DE. Diet and Tumor Genetics Conspire to Promote Prostate Cancer Metabolism and Shape the Tumor Microenvironment. Cancer Res. 2024 Jun 4;84(11):1742-1744. PMID: 38831750.

Cao PHA, Dominic A, Lujan FE, Senthilkumar S, Bhattacharya PK, Frigo DE*, and Subramani E*. Unlocking ferroptosis in prostate cancer— the road to novel therapies and imaging markers. Nat Rev Urol. 2024 Oct;21(10):615-637. PMID: 38627553. (Highlighted by UroToday) *Co-corresponding authors.

Awad D, Cao PHA, Pulliam TL, Spradlin M, Subramani E, Tellman TV, Ribeiro CF, Muzzioli R, Jewell BE, Pakula H, Ackroyd JJ, Murray MM, Han JJ, Leng M, Jain A, Piyarathna B, Liu J, Song X, Zhang J, Klekers AR, Drake JM, Ittmann MM, Coarfa C, Piwnica-Worms D, Farach-Carson MC, Loda M, Eberlin LS, and Frigo DE. Adipose triglyceride lipase is a therapeutic target in advanced prostate cancer that promotes metabolic plasticity. Cancer Res. 2024 Mar 4;84(5):703-724. PMID: 38038968.
 

Subramani E, Dominic A, Bhattacharya PK, Frigo DE, Bederman I, Vaziri-Gohar A. Editorial: Metabolic regulation under oxidative stress in cancer. Front Oncol. 2023 Sep 12;13:1286086. doi: 10.3389/fonc.2023.1286086. PMID: 37771445.

Hasterok S, Scott TG, Roller DG, Spencer A, Dutta AB, Sathyan KM, Frigo DE, Guertin MJ, Gioeli D. The androgen receptor does not directly regulate the transcription of DNA damage response genes. Mol Cancer Res. 2023 Sep 12. doi: 10.1158/1541-7786.MCR-23-0358. Epub ahead of print. PMID: 37698543.

Xu W, Qadir MMF, Nasteska D, Mota de Sa P, Gorvin CM, Blandino-Rosano M, Evans CR, Ashford FB, Bitsi S, Fan J, Bhondeley M, Song K, Sure VN, Schiffer L, Beatty W, Wyatt R, Frigo DE, Liu X, Katakam PV, Arlt W, Buck J, Levin LR, Hu T, Kolls J, Burant CF, Tomas A, Bernal-Mizrachi E, Hodson DJ, and Mauvais-Jarvis F. Architecture of androgen receptor pathways amplifying glucagon-like peptide-1 insulinotropic action in male pancreatic β-cells. Cell Rep. 2023 May 30;42(5):112529. PMID: 37200193.

Hahn AW, Siddiqui BA, Leo J, Dondossola E, Basham KJ, Miranti CK, Frigo DE. Cancer Cell-Extrinsic Roles for the Androgen Receptor in Prostate Cancer. Endocrinology. 2023 Apr 17;164(6):bqad078. doi: 10.1210/endocr/bqad078. PMID: 37192413.

Leo J, Dondossola E, Basham KJ, Wilson NR, Alhalabi O, Gao J, Kurnit KC, White MG, McQuade JL, Westin SN, Wellberg EA, and Frigo DE. Stranger Things: New Roles and Opportunities for Androgen Receptor in Oncology Beyond Prostate Cancer. Endocrinology. 2023 Apr 17;164(6):bqad071. doi: 10.1210/endocr/bqad071. PMID: 37154098.

Wells C, Liang Y, Pulliam TL, Lin C, Awad D, Eduful B, O’Byrne S, Hossain MA, Catta-Preta CMC, Ramos PZ, Gileadi O, Gileadi C, Couñago RM, Stork B, Langendorf CG, Nay K, Oakhill J, Mukherjee D, Racioppi L, Means AR, York B, McDonnell DP, Scott JW, Frigo DE and Drewry DH. SGC-CAMKK2-1: A chemical probe for CAMKK2. Cells 12(2): 287, 2023. PMID: 36672221.

Mossa F, Robesti D, Sumankalai R, Corey E, Titus M, Kang Y, Zhang J, Briganti A, Montorsi F, Vellano CP, Marszaleck JR, Frigo DE, Logothetis CJ, Gujral TS and Dondossola E. Subtype and site specific-induced metabolic vulnerabilities in prostate cancer. Mol Cancer Res 21(1): 51-61, 2023. PMID: 36112348. 

Sakellakis MJ, Hahn AW, Ramachandran S, Zhang M, Hoang A, Song JH, Liu J, Wang F, Basu HS, Sheperd P, Wang X, Frigo DE, Lin SH, Panaretakis T, Zhang J, Navone NM, Troncoso P, Logothetis CJ and Titus MA. Characterization of prostate cancer adrenal metastases: dependence upon androgen receptor signaling and steroid hormones. Prostate Cancer Prostatic Dis (Epub ahead of print), 2022. PMID: 36100698.

Pulliam TL, Awad D, Han JJ, Murray MM, Ackroyd JJ, Goli P, Oakhill JS, Scott JW, Ittmann MM, and Frigo DE. Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer. Cells 11(12): 1890, 2022. PMID: 35741020.

Pulliam TL, Goli P, Awad D, Lin C, Wilkenfeld SR, and Frigo DE. Regulation and Role of CAMKK2 in Prostate Cancer. Nat Rev Urol 19(6):367-380, 2022. PMID: 35474107.

Frigo DE, Bondesson M, and Williams C. Nuclear Receptors: From Molecular Mechanisms to Therapeutics. Essays Biochem 65(6):847-856, 2021. PMID: 34825698. 

Eduful B, O'Byrne S, Temme L, Asquith CRM, Liang Y, Picado A, Pilotte J, Wells C, Zuercher WJ, Catta-Preta C, Ramos PZ, Santiago A, Counago R, Langendorf CG, Nay K, Oakhill JS, Pulliam TL, Lin C, Awad D, Willson TM, Frigo DE, Scott JW, and Drewry DH. Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes. J Med Chem 64(15):10849-10877, 2021. PMID: 34264658.

Barton M, Frigo DE, Madak-Erdogan Z, Mauvais-Jarvis F, and Prossnitz ER. Steroid Hormones and Receptors in Health and Disease: A Research Conference Co-Organized by FASEB and the International Committee on Rapid Responses to Steroid Hormones (RRSH), May 25-27, 2021. FASEB J 35(11):e21858, 2021. PMID: 34634152.

Shatnawi A, Abu Rabe DI and Frigo DE. Roles of the tumor suppressor inhibitor of growth family member 4 (ING4) in cancer. Adv Cancer Res 152:225-262, 2021. PMID: 34353439.

Lin C, Blessing AM, Pulliam TL, Shi Y, Wilkenfeld SR, Han JJ, Murray MM, Pham AH, Duong K, Brun SN, Shaw RJ, Ittmann MM, and Frigo DE. Inhibition of CAMKK2 impairs autophagy and castration-resistant prostate cancer via suppression of AMPK-ULK1 signaling. Oncogene 40(9):1690-1705, 2021. PMID: 33531625.

Subramani E and Frigo DE. Mitochondria in Metabolic Syndrome, Reproduction and Transgenerational Inheritance—Ongoing Debates and Emerging Links. Endocrinology 162(1):bqaa182, 2021. PMID: 33275660.

Dahl HC, Kanchwala M, Thomas-Jardin SE, Sandhu A, Kanumuri P, Xing C, Lin C, Frigo DE and Delk NA. Chronic IL-1 exposure drives LNCaP cells to evolve androgen and AR independence. PLoS One 15(12):e0242970, 2020. PMID: 33326447.

Lin C, Salzillo TC, Bader DA, Wilkenfeld SR, Awad D, Pulliam TL, Dutta P, Pudakalakatti S, Titus M, McGuire SE, Bhattacharya PK and Frigo DE. Prostate Cancer Energetics and Biosynthesis. Adv Exp Med Biol 1210:185-237, 2019. PMID: 31900911.

Dutta P, Salzillo TC, Pudakalakatti S, Gammon ST, Kaipparettu BA, McAllister F, Wagner S, Frigo DE, Logothetis CJ, Zacharias NM and Bhattacharya PK. Assessing Therapeutic Efficacy in Real-time by Hyperpolarized Magnetic Resonance Metabolic Imaging. Cells 8(4). Pii: E340, 2019. PMID: 30978984.

Zacharias N, Lee J, Ramachandran S, Shanmugavelandy S, McHenry J, Dutta P, Millward S, Gammon S, Efstathiou E, Troncoso P, Frigo DE, Piwnica-Worms D, Logothetis CJ, Maity SN, Titus MA and Bhattacharya P. Androgen Receptor Signaling in Castration-Resistant Prostate Cancer Alters Hyperpolarized Pyruvate to Lactate Conversion and Lactate Levels In Vivo. Mol Imaging Biol 21(1):86-94, 2019. PMID: 29748904. 

Awad D, Pulliam TL, Lin C, Wilkenfeld SR and Frigo DE. Delineation of the androgen-regulated signaling pathways in prostate cancer facilitates the development of novel therapeutic approaches. Curr Opin Pharmacol 41:1-11, 2018. PMID: 29609138.

Yu G, Cheng CJ, Lin SC, Lee YC, Frigo DE, Yu-Lee LY, Gallick GE, Titus MA, Nutt LK and Lin SH. Calmodulin kinase II activation through organelle-derived acetyl-CoA promotes prostate cancer cell survival and migration in vitro and metastasis in vivo. Cancer Res 78(10):2490-2502, 2018. PMID: 29535221.

White MA, Tsouko E, Lin C, Rajapakshe K, Spencer JM, Wilkenfeld SR, Vakili SS, Pulliam TL, Awad D, Nikolos F, Katreddy RR, Kaipparettu BA, Sreekumar A, Zhang X, Cheung E, Coarfa C and Frigo DE. GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocr Relat Cancer 25(4):453-469, 2018. PMID: 29431615.

Wilkenfeld SR, Lin C and Frigo DE. Communication between genomic and non-genomic signaling events coordinate steroid hormone actions. Steroids 133:2-7, 2018. PMID: 29155216.

White MA, Lin C, Rajapakshe K, Dong J, Shi Y, Tsouko E, Mukhopadhyay R, Jasso D, Dawood W, Coarfa C and Frigo DE. Glutamine Transporters are Targets of Multiple Oncogenic Signaling Pathways in Prostate Cancer. Mol Cancer Res 15(8):1017-1028, 2017. PMID: 28507054.

Khan AS and Frigo DE. A Spatiotemporal Hypothesis for the Regulation, Role and Targeting of AMPK in Prostate Cancer. Nat Rev Urol 14(3):164-180, 2017. PMID: 28169991.

Blessing AM, Rajapakshe K, Bollu LR, Shi Y, White MA, Pham AH, Lin C, Jonsson P, Cortes CJ, Cheung E, La Spada AR, Bast RC, Merchant FA, Coarfa C and Frigo DE. Transcriptional Regulation of Core Autophagy and Lysosomal Genes by the Androgen Receptor Promotes Prostate Cancer Progression. Autophagy 13(3):506-521, 2017. PMID: 27977328.

Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards D, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G and Sreekumar A. Inhibition of Hexosamine Biosynthetic Pathway Promotes Castration Resistant Prostate Cancer. Nat Commun 7;11612, 2016. PMID: 27194471.

Park JH, Vithayathil S, Kumar S, Sung PL, Dobrolecki LE, Putluri V, Bhat V, Bhowmik S, Gupta V, Arora K, Wu D, Tsouko E, Zhang Y, Maity S, Donti TR, Graham BH, Frigo DE, Coarfa C, Yotnda P, Putluri N, Lewis MT, Sreekumar A, Creighton CJ, Wong LJC and Kaipparettu BA. Fatty Acid Oxidation-Driven Src Links Mitochondrial Energy Reprogramming to the Regulation of Oncogenic Properties in Triple Negative Breast Cancer. Cell Rep 14(9):2154-65, 2016. PMID: 26923594.

Klionsky DJ, Abdelmohsen K, Abe A,…..Frigo DE,……..Zughaier SM. Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition). Autophagy 12(1):1-222, 2016. PMID: 26799652.