- Pancreatic Cancer Research
Welcome to Fleming and Koay Laboratory. We are a translational pancreatic cancer research laboratory. Groups lead by Jason Fleming, M.D., and Eugene Koay, M.D., Ph.D., work hand-in-hand and employ unique patient-based research tools to developing disruptive therapeutic strategies against pancreatic adenocarcinoma, which is one of the most lethal solid tumor malignancies.
Novel Drug Testing Platform
Ex Vivo Testing of Patient-Derived Xenografts Mirrors the Clinical Outcome of Patients with Pancreatic Ductal Adenocarcinoma
Our lab has developed a novel platform for drug testing using patient-derived xenografts. This technology is now available for collaborators around the world.
Regression of Stage IV Pancreatic Cancer to Curative Surgery and Introduction of a Novel Ex-Vivo Chemosensitivity Assay
Cancer Physics and Engineering Laboratory
Transport properties of pancreatic cancer describe gemcitabine delivery and response
We are developing quantitative methods to characterize the imaging properties of human pancreatic cancer. Our recent pancreatic cancer research in JCI shows that imaging-derived transport properties of this disease associate with the delivery of, response to, and outcome after cytotoxic therapies.
Recent Publications Exploring the Role of Lumican in Pancreatic Cancer
Transforming Growth Factor-β Limits Secretion of Lumican by Activated Stellate Cells within Primary Pancreatic Adenocarcinoma Tumors
Extracellular lumican inhibits pancreatic cancer cell growth and is associated with prolonged survival after surgery
Funded Surgery Residents/Fellows under NIH T32 Fellowships
2014-2016 - Dr. Mayrim V. Rios Perez, University of Puerto Rico, Medical Sciences Center, San Juan, PR
2013-2015 - Dr. David Roife, The University of Texas, Health Sciences Center, Houston TX
2011-2012 - Dr. Ryan Thomas, The University of Texas, MD Anderson Cancer Center, Houston TX
2010-2011 - Dr. Mark Truty, Mayo Clinic, Rochester, MN
Our pancreatic cancer research is mainly supported by:
Viragh Family Foundation
Pancreatic Cancer Patient Donations
NIH T32 Research Fellowship
An extensive number of intra- and inter-institutional collaborations with: physicians (i.e. pathologists, cytopathologists, radiologists), scientists (i.e. chemist, biologist, physicist), engineers, and mathematicians (i.e. statistician) are undertaken to move our pancreatic cancer research work forward.