Enderling Laboratory
Heiko Enderling, Ph.D.
Principal Investigator
Areas of Research
- Artificial Intelligence
- Cancer Biology
- Computational Biology
- DNA Damage Response
- Evolution and Development
- Glioblastoma
- Head and Neck Cancer
- Imaging
- Immunology
- Immunotherapy
- Prostate Cancer
- Radiation Oncology
- Radiation Therapy
- Systems Biology
- Tumor Microenvironment
Our lab focuses on developing and applying quantitative mathematical and computational modeling techniques to simulate and predict individual patient treatment responses — transparent, trustworthy and reproducible digital twins for oncology. This positions us at the forefront of ‘virtual trials’ that integrate dynamically evolving patient-specific data to guide optimal treatment for each patient
Recent Publications
-
Local Single-Dose Radiation Improves Adoptive Cell Therapy With Tumor-Infiltrating Lymphocytes
Int J Radiat Oncol Biol Phys. 2025 Nov 15;123(4):1102-1115
Obertopp N, Bekker RA, Grass GD, Zelenka T, Thomas A, Potez M, Ali J, Blauvelt J, Hall AM, Hall MS, Chung CH, Enderling H, Pilon-Thomas S
-
Phase 2 Prospective Trial of Personalized Radiation Therapy Fractionation in Human Papillomavirus Positive Oropharyngeal Cancer
Int J Radiat Oncol Biol Phys. 2026 Jul 15;125(4):1043-1050.
Caudell JJ, Echevarria M, Yang G, Kim Y, Kirtane K, Kish J, Muzaffar J, Zahid M, Chung C, Enderling H
-
Reimagining Cancer Staging in the Era of Evolutionary Oncology
J Natl Compr Canc Netw. 2022 Dec;20(12):1370-1372
Kirtane KS, Zahid MU, Enderling H, Harrison LB
-
Rethinking the immunotherapy numbers game
J Immunother Cancer. 2022 Jul;10(7):e005107
Bekker RA, Zahid MU, Binning JM, Spring BQ, Hwu P, Pilon-Thomas S, Enderling H
-
Tumor-immune ecosystem dynamics define an individual Radiation Immune Score to predict pan-cancer radiocurability
Neoplasia. 2021 Nov;23(11):1110-1122
Alfonso JCL, Grass GD, Welsh E, Ahmed KA, Teer JK, Pilon-Thomas S, Harrison LB, Cleveland JL, Mulé JJ, Eschrich SA, Torres-Roca JF, Enderling H
-
Forecasting Individual Patient Response to Radiation Therapy in Head and Neck Cancer With a Dynamic Carrying Capacity Model
Int J Radiat Oncol Biol Phys. 2021 Nov 1;111(3):693-704
Zahid MU, Mohsin N, Mohamed ASR, Caudell JJ, Harrison LB, Fuller CD, Moros EG, Enderling H
Funding Sources
-
Predict radiation-induced shifts in patient-specific tumor immune ecosystem composition to harness immunological consequences of radiotherapy
U01244100
-
Fractionated photoimmunotherapy to harness low-dose immunostimulation in ovarian cancer
U01280849
-
Developing mathematical model driven optimized recurrent glioblastoma therapies
R21CA263911
Contact Us
Heiko Enderling, Ph.D.
Principal Investigator
HEnderling@MDAnderson.org
832-846-0656
Mailing Address:
UT MD Anderson
Radiation Oncology
TMC3
1515 Holcombe Blvd.
Houston, TX 77030