Research
The Colon and Rectal Surgery department focuses on innovative approaches to the treatment of colon and rectal cancers, linking high-quality patient care, preservation of life and translational research.
Our research spans all aspects and stages of colorectal cancer, from screening and prevention to multi-disiplinary approaches for treating advanced cancers.
Minimally invasive surgery and enhanced recovery
The Colon and Rectal Surgery department is a world leader on innovative treatments of cancer using minimally invasive robotic and laparoscopic techniques, including for complex cancers. We utilize an Enhanced Surgical Recovery program that combines advanced minimally invasive surgery, evidence-based peri-operative care and innovations in tele-health to maximize each patient's healing. This allows our patients to proceed to the next step of treatment faster and healthier.
Topics our group is studying:
- TeleRecovery to facilitate short-stay enhanced recovery after minimally-invasive surgery for colorectal cancer
- Tele-health for patients with an ostomy
- Short and long-term clinical outcomes after robotic surgery
- Advanced minimally invasive robotic surgery for complex cancers
Advanced techniques and multi-disciplinary treatment for advanced tumors
Our group has internationally recognized expertise in the evaluation and treatment of locally advanced and recurrent cancers. Our faculty are thought leaders in advanced techniques necessary to perform high-quality surgery for complex pelvic tumors. We partner with experts across MD Anderson to ensure a thoughtful approach to difficult-to-treat tumors that will provide the best outcomes for our patients.
Topics our group is studying:
- Role of pelvic exenteration for curative management of locally advanced and recurrent rectal cancer
- Multi-discplinary management for lateral pelvic lymph node metastasis from rectal cancer
- Quality standards for colon and rectal cancer surgery
- Impact of primary tumor resection in stage IV colorectal cancer
Organ preservation and quality of life
Our multidisciplinary experts tailor cancer therapy for each patient using advanced chemotherapy, radiotherapy and immunotherapy before surgery. The goal of such comprehensive cancer care is not only improving outcomes after surgery but maximizing the chance to preserve function and improve quality of life after surgery.
Topics our group is studying:
- Short-course and total neoadjuvant therapy for rectal cancer
- Avoiding the need for surgery (watch and wait) for rectal cancer
- Advanced surgical techniques to preserve sphincter function
- Cancer survivorship and quality of life after colorectal cancer treatment
Hereditary and young-onset colorectal cancer
The Colon and Rectal Surgery department at MD Anderson has extensive experience in the treatment of hereditary colorectal cancers and hereditary syndromes that include colorectal cancer. Young patients with colorectal cancer need specialized cancer care. This includes surveillance of possible future secondary cancers and screening of family members. We partner with the Colorectal Center Genetics Clinic to provide surveillance, prevention and genetic risk evaluation for patients with inherited or early-onset cancer.
Topics our group is studying:
- Practice guidelines for young adult-onset colorectal cancer
- Genetic factors associated with young-onset colorectal cancer
- Screening for colorectal cancer
Peritoneal carcinomatosis
The Colorectal Center at MD Anderson combines the expertise of medical oncologists, surgeons and translational researchers to study and treat peritoneal carcinomatosis (metastases within the abdominal cavity) from colorectal cancer. Our institution cares for patients with a wide spectrum of disease and provides individualized treatment plans tailored to each person's unique biology and situation.
Topics our group is studying:
- Genetics-guided treatment of colorectal cancer
- Genomics of metastatic colorectal cancer and carcinomatosis
- Outcomes following cytoreductive surgery for colorectal carcinomatosis
Translational Research
Research that translates into improved outcomes for cancer is the heart of M.D. Anderson. Our clinician-scientists work across the spectrum of disciplines to develop innovative approaches to treat cancer from the earliest to most advanced stages. We collaborate closely with international leaders in the study of the basic mechanisms of cancer development and novel treatments for colorectal cancer. Many treatment options are available, including clinical trials
Topics our group is studying:
- Using next-generation sequencing and circulating tumor DNA to guide treatment decisions
- The interaction of the immune system and colorectal cancer
- The biology of colorectal cancer growth and metastatic spread