Mark Pagel, Ph.D. - Professor and Deputy Chair, Cancer Systems Imaging; Professor, Imaging Physics
Research Interests: Imaging the tumor microenvironment; imaging tumor acidosis, enzyme activity, oxygenation and vascular permeability; CEST MRI, PET/MRI MR Fingerprinting, Electron Paramagnetic Resonance Imaging and MultiSpectral Optoacoustic Tomography.
Ellen Ackerstaff, Ph.D. – Assistant Professor
Research Interests: Exploring the tumor microenvironment (TME) –including and not limited to vascularity, cancer metabolism, hypoxia, pH, and tumor-stroma interactions – in vitro, in vivo, and ex vivo to establish the TME’s impact on tumor progression and treatment response. My research employs multi-nuclear and multimodal imaging and other techniques to characterize the TME in untreated and treated tumors and tumor or stromal cells.
Sahil Bajaj, Ph.D. – Assistant Professor
Research Interests: Functional and Structural MRI, Diffusion Tensor Imaging, Functional Near-Infrared Spectroscopy, Brain Morphometry, Brain Connectivity (functional, structural, directed functional/Granger causality and effective/dynamic causal modeling), Machine Learning, Mental Distress and Sleep Disorders
Pratip Bhattacharya, Ph.D. – Associate Professor, Cancer Systems Imaging & Imaging Physics
Research Interests: Hyperpolarized MRI, Dynamic Nuclear Polarization (DNP), real-time molecular and metabolic imaging in different cancer systems, targeted molecular imaging by Positron Emission Tomography (PET) and hyperpolarized silicon MRI, metabolomics.
Daniel Frigo, Ph.D. - Associate Professor, Cancer Systems Imaging & Genitourinary Medical Oncology
Research Interests: Understanding how various signaling pathways, such as those regulated by the androgen receptor, CaMKK2, AMPK, mTOR and Myc, drive the progression of prostate cancer. Goal: To exploit these newly uncovered pathways for therapeutic purposes. Interestingly, many of these signaling pathways converge at various metabolic nodes. The end result is a shift in oncogenic metabolism that allows the cancer cells to utilize a diverse array of nutrients to the benefit of the cancer cell.
Seth Gammon, Ph.D. – Associate Professor
Research Interests: Development of imaging inspired therapeutics including radiolabeled antibodies, Development of new PET or hyperpolarized MRI agents for study of the adaptive and innate immune systems; Leveraging existing PET, MRI, bioluminescent and fluorescent reporters for studying the complex interaction of the innate immune system, tumor biology, and cancer chemotherapeutics
Brian Grindel, Ph.D. – Instructor
Research Interests: Directed evolution of peptide imaging agents and therapeutics using mRNA display. Developing and characterizing peptide and molecular agents targeting autophagy, immune checkpoint modulation, and metabolism in cancer.
Loukia Karacosta, Ph.D. – Assistant Professor
Research Interests: Leveraging cancer systems biology approaches and single-cell technologies like mass cytometry (CyTOF) and multiplexed imaging, to interrogate phenotypic plasticity and the spatiotemporal dynamics that drive therapy resistance in the tumor microenvironment.
H. Charles Manning, Ph.D. – Professor, Cancer Systems Imaging; Director, Cyclotron Radiochemistry Facility; Scientific Director, Center for Advanced Biomedical Imaging
Research Interests: Development, validation, implementation, and clinical translation of imaging and chemical probes to non-invasively quantify molecular events in vivo.
Shivanand Pudakalakatti, Ph.D. – Instructor
Research Interests: Understanding the role of metabolism in growth, survival, relapse, and treatment in various cancer systems employing magnetic resonance and other biophysical techniques. Taking the advantages of alteredmetabolism, next generation diagnostic and therapeutic intervention biomarkers will be identified, and drugs will be developed for treatment.
C. Chad Quarles, Ph.D. – Professor
Research Interests: Preclinical discovery, refinement and clinical translation of multi-modality neuroimaging technologies with application to brain cancer, cancer neuroscience and neurohealth; projects and applications include MRI physics and engineering, MR-based biomarker discovery, simultaneous PET/MRI, radiopathomics, emerging radiotracers, functional neuroimaging, multi-modality and integrative AI-based analytics, neurosurgical guidance, biology-based radiotherapy, therapy response assessment, image-based pharmacokinetics and pharmacodynamics
Elavarasan Subramani, Ph.D. – Instructor
Research Interests: Decoding the metabolic dependencies and its interaction with epigenetic changes in prostate cancer; Understanding the molecular drivers of cancer plasticity for the development of novel therapeutic strategies; Metabolic markers identification for non-invasive cancer detection and assessment of therapy response.
Dawn Jefferson, M.S.
Senior Administrative Assistant
Diana Marshall, M.B.A, M.S.
Associate Director, Research Planning & Development
Galina Mikheeva, M.S.
Associate Director, Laboratory Operations, Cancer Systems Imaging
Grant Program Coordinator
Adam C. Vasconcellos
Grant Program Coordinator