Core A: Integrated Clinicopathology and Biorepository Core
Co-Directors: John Phay, M.D. and Rebecca Nagy, M.S., CGC (OSUCCC); Adel El-Naggar, M.D. (MD Anderson)
This Shared Resource Core is required by the SPORE as a Biospecimen and Biorepository Core. However, we have also chosen to incorporate clinical expertise into the Core under the combined leadership of El-Naggar and Paul Wakely Jr., M.D., thus harnessing pathology expertise at both institutions. Full integration of pathology and laboratory samples with clinical information and a clinical database is an innovative approach and crucial for maximal impact on the projects and on thyroid cancer research. We believe that upfront collection of detailed clinical information through IRB-approved protocols is essential to facilitate translational research. This principle has been utilized by both groups and the result is rapid translation of research into the clinic.
Core B: Biostatistics Core
Director: Soledad Fernandez, Ph.D. (OSUCCC)
Core B will provide biostatistical and bioinformatics analysis support to each of the projects as well as to investigators selected for Developmental Research or Career Development Projects. The approach of this Core has been to be involved in the experimental design of both laboratory and clinical studies to ensure robust and rigorous initial study design to test hypotheses appropriately. Fernandez is the Director of the OSUCCC Shared Biostatistical Resource and leads a team of statisticians that brings skills for specific types of analyses to the group. Our approach has not been to include individual biostatisticians in each project, but rather to have the core provide these services and support personnel for this critical work. Our philosophy is that full integration and consistency in analysis is essential to the overall success of the SPORE; therefore, all statistical analyses in all projects at both sites will be performed by Dr. Fernandez and her group at OSU.
Core C: Administrative Core
Director: Matthew D. Ringel M.D. (OSUCCC); Co-Director: Gilbert Cote, Ph.D. (MD Anderson)
Core C will serve a primary integrative role for the SPORE with a goal to facilitate the success of each individual project in all components. Ringel, Director of the Administrative Core, has extensive experience in this area from other multi-center grant leadership roles. Cote will serve as the Director for the Administrative Core at MD Anderson. The Core will arrange an annual meeting of SPORE investigators to facilitate scientific exchange, investigator interactions, review of all components, and review of progress. This meeting will include the internal and external SPORE Advisory Boards and will contribute to annual progress reports to the NCI. Core C will assist with budget reviews and analysis to ensure efficient and appropriate use of funds, will organize and maintain a secured website, and arrange regular multi-site teleconferences and web-based presentations. The Core will also assist the Developmental Research and Career Development Programs (see below). In addition, the Core will facilitate investigator interactions at both participating institutions. Core C will function with the existing structures at both OSUCCC and MD Anderson, but will focus on SPORE-specific issues that are beyond the scope of the general Shared Resource Cores at the two institutions, including supporting and encouraging interSPORE collaborations.