Randy Johnson Laboratory
Randy Johnson, Ph.D.
Principal Investigator
Areas of Research
- Genetics
- Developmental Biology
Welcome to the Johnson Laboratory! The broad research focus areas of our laboratory are genetic mechanisms of development and congenital birth defects, dorsal-ventral limb patterning, ocular development and disease, and the tumor suppressor pathway Hippo Pathway.
Notable Publications
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Nature Reviews Drug Discovery, 2014
The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment
R.L. Johnson and G. Halder
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Cancer Research, 2014
The Hippo coactivator Yap1 upregulates Sox9 and endows cancer stem cell properties in non-tumorigenic cells and esophageal cancer cells
S. Song, J.A. Ajani, H. Soichiro, S. Ailing, Y. Yao, D.M. Maru, M.C. Hung and R.L. Johnson
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Hepatology, 2016
Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ
J. Yi, L. Lu, K. Yander, W. Wang, B.H. Sohn, B.Z. Stanger, M. Zhang, J.F. Martin, J.S. Lee, J.A. Ajani, J. Chen, S. Song, R.L. Johnson
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Genes & Development, 2016
The Lats2 tumor suppressor inhibits SREBP and suppresses hepatic cholesterol accumulation
Y. Aylon, A. Gershoni, R. Rotkopf, I.E. Biton, Z. Porat, A. Koh, X. Sun, Y. Lee. M.I. Fiel, Y. Hoshida, S.L. Friedman, R.L. Johnson, M. Oren
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Experimental & Molecular Medicine, 2018
The Hippo pathway coactivators Yap and Taz are required for coordinated cell cycle entry and restoration of organ size following partial hepatectomy
L. Lu, M.J. Finegold and R.L. Johnson
