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Publications
Peer-Reviewed Original Research Articles
Mu, Y., Zelazowska, M., McBride, KM. Phosphorylation Promotes Activation-Induced Cytidine Deaminase Activity at the Myc Oncogene. J Exp Med 214(12):3543-3552, 2017.
Takata KI, Reh S, Yousefzadeh MJ, Zelazowski MJ, Bhetawal S, Trono D, Lowery MG, Sandoval M, Takata Y, Lu Y, Lin K, Shen J, Kusewitt DF, McBride KM, Cole F, Wood RD. Analysis of DNA polymerase v function in meiotic recombination, immunoglobulin class-switching, and DNA damage tolerance. PLoS Genet 13(6):e1006818, 2017.
Perfetti M, Baughman B, Dickson B, Mu Y, Cui G, Mader P, Dong A, Norris J, Rothbart S, Strahl B, Brown P, Jansen W, Arrowsmith C, Mer G, McBride KM, James L, Frye S. Identification of a Fragment-like Small Molecule Ligand for the Methyl-lysine Binding Protein, 53BP1. ACS Chem Biol 10(4):1072-81, 2015
Minkah N, Macaluso M, Oldenburg D, Paden C, White D, McBride KM, Krug L. Absence of the Uracil DNA Glycosylase of Murine Gammaherpesvirus 68 Impairs Replication and Delays the Establishment of Latency In Vivo. J Virol 89(6):3366-79, 2015.
Kracker S. Di Virgilio M, Schwartzentruber J, Cuenin C, Forveille M, Deau M, McBride KM, Majewski J, Gazumyan A, Seneviratne S, Grimbacher B, Kutukculer N, Herceg Z, Calvo M, Jabado N, Nussenzweig M, Fischer A, Durandy A. An inherited immunoglobulin class-switch recombination deficiency associated with a defect in the INO80 chromatin remodeling complex. J Allergy Clin Immunol . 135(4):998-1007, 2014.
Yousefzadeh, M, Wyatt D, Takata K, Mu Y, Hensley S, Tomida J, Bylund G, Doublie S, Johansson E, Ramsden D, McBride KM, Wood, R. Mechanism of suppression of chromosomal instability by DNA polymerase POLQ. PLoS Genet 10(10):e1004654,2014.
Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford M. Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell 53(3):484-97, 2014.
Yates JL, Racine R, McBride KM, Winslow GM. T cell-dependent IgM memory B cells generated during bacterial infection are required for IgG responses to antigen challenge. J Immunol 191(3):1240-9, 2013.
Gazumyan A, Bothmer A, Klein IA, Nussenzweig MC, McBride KM. Activation-induced cytidine deaminase in antibody diversification and chromosome translocation. Adv Cancer Res 113:167-90, 2012.
Gazumyan A, Timachova K, Yuen G, Siden E, Di Virgilio M, Woo EM, Chait BT, Reina San-Martin B, Nussenzweig MC, McBride KM. Amino terminal phosphorylation of activation-induced cytidine deaminase suppresses c-myc/IgH translocation. Mol Cell Biol 31(3):442-9, 2011.
Yamane A, Resch W, Kuo N, Kuchen S, Li Z, Sun HW, Robbiani DF, McBride K, Nussenzweig MC, Casellas R. Deep-sequencing identification of the genomic targets of the cytidine deaminase AID and its cofactor RPA in B lymphocytes. Nat Immunol 12(1):62-9, 2011.
Robbiani DF, Bunting S, Feldhahn N, Bothmer A, Camps J, Deroubaix S, McBride KM, Klein IA, Stone G, Eisenreich TR, Ried T, Nussenzweig A, Nussenzweig MC. AID produces DNA double-strand breaks in non-Ig genes and mature B cell lymphomas with reciprocal chromosome translocations. Mol Cell 36(4):631-41, 2009.
McBride KM, Gazumyan A, Woo EM, Schwickert TA, Chait BT, Nussenzweig MC. Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med 205(11):2585-94, 2008.
Dorsett Y, McBride KM, Jankovic M, Gazumyan A, Thai TH, Robbiani DF, Di Virgilio M, Reina San-Martin B, Heidkamp G, Schwickert TA, Eisenreich T, Rajewsky K, Nussenzweig MC. MicroRNA-155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 28(5):630-8, 2008.
Shen HM, Bozek G, Pinkert CA, McBride KM, Wang L, Kenter A, Storb U. Expression of AID transgene is regulated in activated B cells but not in resting B cells and kidney. Mol Immunol 45(7):1883-92, 2008.
Chatterji M, Unniraman S, McBride KM, Schatz DG. Role of activation-induced deaminase protein kinase A phosphorylation sites in Ig gene conversion and somatic hypermutation. J Immunol 179(8):5274-80, 2007.
Callén E, Jankovic M, Difilippantonio S, Daniel JA, Chen HT, Celeste A, Pellegrini M, McBride KM, Wangsa D, Bredemeyer AL, Sleckman BP, Ried T, Nussenzweig M, Nussenzweig A. ATM prevents the persistence and propagation of chromosome breaks in lymphocytes. Cell 130(1):63-75, 2007.
Ramiro A, Reina San-Martin B, McBride KM, Jankovic M, Barreto V, Nussenzweig A, Nussenzweig MC. The role of activation-induced deaminase in antibody diversification and chromosome translocations. Adv Immunol 94:75-107, 2007.
McBride KM, Gazumyan A, Woo EM, Barreto VM, Robbiani DF, Chait BT, Nussenzweig MC. Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci. 2006 Jun;103(23):8798-803.
Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 2006 Mar 2;440(7080):105-9.
Liu L, McBride KM, Reich NC. STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3. Proc Natl Acad Sci U S A 102(23):8150-5, 2005.
McBride KM, Barreto V, Ramiro AR, Stavropoulos P, Nussenzweig MC. Somatic hypermutation is limited by CRM1-dependent nuclear export of activation-induced deaminase. J Exp Med 199(9):1235-44, 2004.
Barreto V, Reina-San-Martin B, Ramiro AR, McBride KM, Nussenzweig MC. C-terminal deletion of AID uncouples class switch recombination from somatic hypermutation and gene conversion. Mol Cell 12(2):501-8, 2003.
McBride KM and Reich NC. The ins and outs of STAT1 nuclear transport. Sci STKE. 2003(195):RE13, Review, 2003.
Brown MT, McBride, KM, Baniecki ML, Reich NC, Marriott G, Mangel WF. Actin can act as a cofactor for a viral proteinase in the cleavage of the cytoskeleton. J Biol Chem 277(48):46298-303, 2002.
McBride KM, Banninger G, McDonald C, and Reich NC. Regulated nuclear import of the STAT1 transcription factor by direct binding of Importin-alpha. EMBO J 21(7):1754-63, 2002.
McBride KM, McDonald C, Reich NC. Nuclear export signal located within the DNA-binding domain of the STAT1transcription factor. EMBO J. 19(22):6196-206, 2000.
Kumar KP, McBride KM, Weaver BK, Dingwall C, and Reich NC. Regulated nuclear-cytoplasmic localization of interferon regulatory factor 3, a subunit of double-stranded RNA-activated factor 1. Mol Cell Biol 20(11):4159-68, 2000.
Book Chapters
McBride KM and Reich NC. Signal Transducers and Activators of Transcription (STATs): Activation and Biology, PB. Sehgal, D.E. Levy and T. Hirano, Eds. Kluwer Academic Press, The Netherlands, chap. 20 (2003)