Jiang Laboratory
Fuguo Jiang, Ph.D.
Principal Investigator
Areas of Research
- RNA Biology Research
- Cancer Biology Research
- Structural Biology
Welcome to the Jiang Laboratory at MD Anderson Cancer Center. Our laboratory studies the molecular mechanisms of CRISPR genome editing and its therapeutic applications in human cancer diseases. In addition, our laboratory aims to reveal the working mechanisms of significant RNA Binding Proteins (RBPs) in tumor formation and metastasis as well as the structural mechanisms of epigenetic deregulation in cancer development using a range of biochemical, structural biology and cell-based techniques.
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Welcome to the Jiang Laboratory
The broad research focus areas in our laboratory are:
- Structural Biology of Protein & Nucleic Acid Complexes in Host Defense
- Molecular Mechanism of CRISPR Genome Editing Machinery
- RNA Editing and Innate Immunity in the Pathogenesis of Cancer
- Mechanism of ATP-Dependent Chromatin Remodeling Complex in Tumorigenesis
Notable Recent Publications
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Molecular Cell, 2018
Temperature-responsive competitive inhibition of CRISPR-Cas9
Jiang F, Liu J-J, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J & Doudna JA
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Science, 2016
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA
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Science, 2015
A Cas9-guide RNA complex preorganized for target DNA recognition
Jiang F, Zhou K, Ma L, Gressel S, Doudna JA
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Science, 2014
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Jinek M*, Jiang F*, Taylor DW*, Sternberg SH*, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA
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Nature, 2011
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
Jiang F, Ramanathan A, Miller MT, Tang GQ, Gale M Jr, Patel SS, Marcotrigiano J