Jiang Laboratory
Fuguo Jiang, Ph.D.
Principal Investigator
Welcome to the Jiang Laboratory at MD Anderson Cancer Center.
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Welcome to the Jiang Laboratory
The broad research focus areas in our laboratory are:
- Structural Biology of Protein & Nucleic Acid Complexes in Host Defense
- Molecular Mechanism of CRISPR Genome Editing Machinery
- RNA Editing and Innate Immunity in the Pathogenesis of Cancer
- Mechanism of ATP-Dependent Chromatin Remodeling Complex in Tumorigenesis
Notable Recent Publications
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Molecular Cell, 2018
Temperature-responsive competitive inhibition of CRISPR-Cas9
Jiang F, Liu J-J, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J & Doudna JA
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Science, 2016
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA
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Science, 2015
A Cas9-guide RNA complex preorganized for target DNA recognition
Jiang F, Zhou K, Ma L, Gressel S, Doudna JA
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Science, 2014
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
4. Jinek M*, Jiang F*, Taylor DW*, Sternberg SH*, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA
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Nature, 2011
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
Jiang F, Ramanathan A, Miller MT, Tang GQ, Gale M Jr, Patel SS, Marcotrigiano J