Jiang Laboratory
Fuguo Jiang, Ph.D.
Principal Investigator
Welcome to the Jiang Laboratory
The broad research focus areas in our laboratory are:
- Biochemical and Integrative Structural Biology of Genome Editing
- Molecular Mechanisms of RNA-Guided DNA Targeting by CRISPR-Cas
- RNA Editing and Innate Immunity in the Pathogenesis of Cancer
- ATP-Dependent Chromatin Remodeling Machinery
Notable Recent Publications
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Molecular Cell, 2018
Temperature-responsive competitive inhibition of CRISPR-Cas9
Jiang F, Liu J-J, Osuna BA, Xu M, Berry JD, Rauch BJ, Nogales E, Bondy-Denomy J & Doudna JA
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Annual Review of Biophysics, 2017
CRISPR-Cas9 Structures and Mechanisms
Jiang F, Doudna JA.
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Science, 2016
Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage
Jiang F, Taylor DW, Chen JS, Kornfeld JE, Zhou K, Thompson AJ, Nogales E, Doudna JA
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Science, 2015
A Cas9-guide RNA complex preorganized for target DNA recognition
Jiang F, Zhou K, Ma L, Gressel S, Doudna JA
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Nature, 2011
Structural basis of RNA recognition and activation by innate immune receptor RIG-I
Jiang F, Ramanathan A, Miller MT, Tang GQ, Gale M Jr, Patel SS, Marcotrigiano J