The Genetics department is an outstanding environment for basic science and translational research. There is a strong core of post doctoral trainees that contribute to the research. The faculty are funded through several mechanisms including a large number of NCI R01 grants, CPRIT (Cancer Prevention & Research Institute of Texas), grants from other agencies and philanthropy. Grants to the department total approximately 10 million dollars annually in direct costs. The research in the department is also greatly enhanced by departmental infrastructure and leadership in institutional core facilities.
The Advanced Technology Genomics Core (ATGC) is an institutional core facility partially funded by the Cancer Center Support Grant (CCSG). The ATGC provides MD Anderson investigators with reliable nucleic acid analysis services using traditional and next generation sequencing technologies, and microarray platforms. The ATGC is directed by Vicki Huff, Ph.D., managed by Erika Thompson and administered through the Department of Genetics.
This CPRIT-funded facility supports collaborative projects and core services for single cell sequencing technologies. The core is directed by Nicholas Navin, Ph.D. and consists of four main components:
1. Tissue dissociation facility
2. Technologies & assays
3. Next-generation sequencing
4. Data processing & analysis
The primary goal of this core is to offer conventional and molecular cytogenetic services, including species identification, karyotyping, analysis of genomic instability, fluorescence in situ hybridization and spectral karyotyping. Guillermina (Gigi) Lozano, Ph.D., is the director and Asha S. Multani, Ph.D., is the co-director of the facility. (CCAC) is administered through the Department of Genetics.
Genetically Engineered Mouse Facility (GEMF)
The purpose of the Genetically Engineered Mouse Facility (GEMF) is to provide technologically advanced and efficient mouse mutation resources to faculty members at the institution. Modifications to the genome utilizing direct DNA injection and ES cell mutagenesis, cryopreservation, in vitro fertilization and rederivation of mouse lines are all technologies supported by the facility. The facility is fully equipped with the latest instrumentation and staffed with highly skilled personnel trained specifically for the production of mutant mice. GEMF is administered by Jan Parker-Thornburg, Ph.D., through Department of Genetics.
The Department of Genetics maintains a modern Microscopy Core with multiple platforms for live imaging, deconvolution, confocal, stereofluorescence, and brightfield microscopy. Imaging is supported by numerous software programs for processing and analyzing datasets. The Core is directed by Adriana Paulucci, Ph.D., who maintains the imaging equipment and trains departmental members on their use.