A Phase I/II Study of Quizartinib in Combination with Decitabine and Venetoclax for the Treatment of Patients with Acute Myeloid Leukemia (AML)
MD Anderson Study Status
decitabine, Quizartinib (AC220), Decitabine, Quizartinib, Venetoclax
This phase I/II trial studies how well quizartinib, decitabine, and venetoclax work in treating participants with acute myeloid leukemia or high risk myelodysplastic syndrome that is untreated or has come back. Quizartinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as decitabine and venetoclax, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving quizartinib and decitabine may work better at treating acute myeloid leukemia and myelodysplastic syndrome.
Information and next steps
For general questions about clinical trials: