Biomarker in pancreatic cysts could predict risk of cancer progression
Pancreatic cysts are fluid-filled growths that appear on or in the pancreas and have the potential to develop into pancreatic cancer. Currently, few tools are available to reliably predict which cysts are likely to progress. To identify predictive biomarkers, researchers led by Johannes Fahrmann, Ph.D., used advanced techniques to study the metabolites in cystic fluid and to evaluate the spatial distribution of key genes...
Heated chemotherapy improves overall survival in some patients with colorectal cancer
Some patients with advanced colorectal cancer develop metastases in the lining of the abdominal cavity, known as peritoneal metastases...
Researchers identify driver of nervous system overactivity in hypertension
The hypothalamus is an area of the brain that controls the sympathetic nervous system – which regulates the fight or flight response – by...
Researchers identify novel target for high-risk multiple myeloma
High-risk multiple myeloma is an aggressive disease in which plasma cells grow uncontrollably. It is typically resistant to treatment and the prognosis for patients is poor. However, the genes that contribute to this behavior are not fully understood. Using single-cell transcriptomics, researchers led by Robert Orlowski, M.D., Ph.D., identified that CLPP, a protein in mitochondria, is overexpressed in high-risk cases and may also...
Targeting cells that form blood vessels in glioblastoma could improve treatment
The formation of new, small blood vessels – known as microvascular proliferation (MVP) – is a hallmark of glioblastoma, the most common and...
Researchers identify CREM as a critical regulator of CAR NK cell function
Chimeric antigen receptor (CAR) natural killer (NK) cells represent a promising experimental cell therapy, but the molecular mechanism regulating...
Study uncovers novel role for BRCA2, suggesting new therapeutic strategies
BRCA2, a key tumor suppressor that helps repair and protect DNA during replication, is often mutated in cancer cells. Normally, BRCA2 interacts...