Philip Lorenzi, Ph.D.

Supervisor, Laboratory and Research
Co-Director, Proteomics and Metabolomics Core Facility


  • Ph.D. in Pharmaceutics, University of Michigan, Ann Arbor, MI
  • M.S. in Pharmaceutics, University of Michigan, Ann Arbor, MI
  • B.S. in Chemistry, Loyola University Chicago, Chicago, IL


Chaluvally-Raghavan P, Zhang F, Pradeep S, Hamilton M, Zhao X, Moss T, Lu Y, Yu S, Pecot CV, Aure MR, Peuget S, Rodriguez-Aguayo C, Han H-D, Zhang HD, Liu W, Venkatanarayan A, Liu Z,  Lopez-Berestein G, Kristensen VN, Gagea M, Ram P, Lorenzi PL, Borresen-Dale AL, Chin K, Gray JW, Dusetti NJ, McGuire S, Flores ER, Sood AK, Mills GB. Copy number gain of hsa-miR-569 at 3q26.2 leads to loss of TP53INP1 and aggressiveness of epithelial cancers. Cancer Cell 2014; 26(6):863-879.  PMCID: PMC4261159 [Available 2015-12-08]

Purwaha P, Silva LP, Hawke D, Weinstein JN, Lorenzi PL. An artifact in LC-MS/MS measurement of glutamine and glutamic acid: in-source cyclization to pyroglutamic acid. Analytical Chemistry 2014; 86(12):5633-5637. PMCID: PMC4063328 [Available 2015-06-03]

Chan WK, Lorenzi PL, Anishkin A, Purwaha P, Rogers DM, Sukharev S, Rempe SB, Weinstein JN. The glutaminase activity of L-asparaginase is not required for anticancer activity against ASNS-negative cell lines. Blood 2014; 123(23):3596-3606. PMCID: PMC4047499

Purwaha P, Lorenzi PL,Hawke D, Weinstein JN. Targeted metabolomic analysis of amino acid response to L-asparaginase in adherent cells using MRM-based quantitation. Metabolomics 2014; 10(5):909-919. PMCID: PMC4145215

Lorenzi PL, Claerhout S, Mills GB, Weinstein JN. A curated census of autophagy-modulating proteins and small molecules: candidate targets for cancer therapy. Autophagy 2014; 10(7):1316-1326.  PMCID: PMC4203555 [Available 2015-07-01]

The Cancer Genome Atlas Research Network (P.L. Lorenzi).  Comprehensive molecular characterization of urothelial bladder carcinoma. Nature 2014; 507(7492):315-322. PMCID: PMC3962515

 Weinstein JN, Lorenzi PL. Discrepancies in drug sensitivity (News & Views). Nature 2013; 504(7480):381-383.PMID: 24284624

The Cancer Genome Atlas Research Network (P.L. Lorenzi).  The Cancer Genome Atlas pan-cancer analysis project. Nature Genetics 2013; 45(10):1113-1120. PMCID: PMC3919969

Silva LP, Lorenzi PL, Yong V, Hawke D, Weinstein JN. Measurement of DNA concentration as a normalization strategy for metabolomic data from adherent cell lines. Analytical Chemistry 2013; 85(20):9536-9542. PMCID:PMC3868625

Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z. Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules. Oncogene 2013; 33(26):3463-3472. PMCID: PMC3915040 [Available 2015-06-26]

Claerhout S, Lorenzi PL, Weinstein JN, Mills GB. Modulation of autophagy and its potential for cancer therapy.  Drugs of the Future 2011; 36(12): 919-925. doi: 10.1358/dof.2011.036.12.1711892

Liu H, D’Andrade P, Fulmer-Smentek S, Lorenzi PL, Kohn KW, Weinstein JN, Pommier Y, Reinhold WC.  mRNA and microRNA expression profiles of the NCI-60 integrated with drug activities. Molecular Cancer Therapeutics 2010; 9(5): 1080-1091. PMCID: PMC2879615

Reinhold WC, Reimers MA, Lorenzi PL, Ho J, Shankavaram UT, Ziegler MS, Bussey KJ, Kaldjian E, Nishizuka S, Ikediobi O, Pommier YG, Weinstein JN. Multifactorial regulation of E-cadherin expression: an integrative study. Molecular Cancer Therapeutics 2010; 9(1): 1-16. PMCID: PMC2821037

Jobson AG, Lountos GT, Lorenzi PL, Llamas J, Connelly J, Tropea JE, Onda A, Kondapaka S, Caplen N, Monks A, Self C, Waugh DS, Shoemaker RH, Pommier Y. Cellular inhibition of checkpoint kinase 2 (Chk2) and potentiation of camptothecins and radiation by the novel Chk2 inhibitor PV1019 [7-nitro-1H-indole-2-carboxylic acid {4-[1-(guanidinohydrazone)-ethyl]-phenyl}-amide]. Journal of Pharmacology and Experimental Therapeutics 2009; 331(3): 816-826. PMCID: PMC2784710

Lorenzi PL, Reinhold WC, S Varma, AA Hutchinson, Y Pommier, SJ Chanock, JN Weinstein. DNA fingerprinting of the NCI-60 cell line panel. Molecular Cancer Therapeutics 2009; 8(4): 713-724. PMCID: PMC4020356

Lorenzi PL, Weinstein JN. Asparagine synthetase: a new potential biomarker in ovarian cancer. Drug News and Perspectives 2009; 22(1): 61-64. PMCID: PMC4096155

Lorenzi PL, Ryan MC, Ikediobi ON, Weinstein JN. ASNS (asparagine synthetase). Atlas of Genetics and Cytogenetics in Oncology and Haematology 2008.

Lorenzi PL, Llamas J, Gunsior M, Ozbun L, Reinhold WC, Ji H, Kim H, Goldsmith PK, Birrer MJ, Weinstein JN. Asparagine synthetase is a biomarker of L-asparaginase activity in ovarian cancer cell lines. Molecular Cancer Therapeutics 2008; 7(10): 3123-3128. PMCID: PMC4123961

Blower PE, Verducci JS, Lin S, Zhou J, Chung J-H, Dai Z, Liu C-G, Reinhold W, Lorenzi PL, Kaldjian EP, Croce CM, Weinstein JN, Sadee W. MicroRNA expression profiles for the NCI-60 cancer cell panel. Molecular Cancer Therapeutics 2007; 6(5): 1483-1491. PMID 17483436

Martin SE, Jones TL, Thomas CL, Lorenzi PL, Nguyen DA, Runfola T, Gunsior M, Weinstein JN, Goldsmith PK, Lader E, Huppi K, Caplen NJ. Multiplexing siRNAs to compress RNAi-based screen size in human cells. Nucleic Acids Research 2007; 35(8): e57. PMCID: PMC1885663

Miao ZH, Player A, Shankavaram U, Wang YH, Zimonjic DB, Lorenzi PL, Liao ZY, Liu H, Shimura T, Zhang HL, Meng LH, Zhang YW, Kawasaki ES, Popescu NC, Aladjem MI, Goldstein D, Weinstein JN, Pommier Y. Nonclassic functions of human topoisomerase I: genome-wide and pharmacologic analyses. Cancer Research 2007; 67(18): 8752-8761. PMID: 17875716

Lorenzi PL, Reinhold WC, Rudelius M, Gunsior M, Shankavaram U, Bussey KJ, Scherf U, Eichler GS, Martin SE, Chin K, Gray JW, Kohn EC, Horak ID, Von Hoff DD, Raffeld M, Goldsmith PK, Caplen NJ, Weinstein JN. Asparagine synthetase as a causal, predictive biomarker for L-asparaginase activity in ovarian cancer cells. Molecular Cancer Therapeutics 2006; 5(11): 2613-2623. PMID: 17088436

Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon JG. N-methylpurine DNA glycosylase and 8-oxoguanine DNA glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(β-D-ribofuranosyl)benzimidazole. Drug Metabolism and Disposition 2006; 34(6): 1070-1077. PMID: 16565170

Landowski CP, Lorenzi PL, Song X, Amidon GL. Nucleoside ester prodrug substrate specificity of carboxylesterase. Journal of Pharmacology and Experimental Therapeutics 2005; 316(2): 572-580. PMID: 16223870

Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL. Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(β-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo. Journal of Pharmacology and Experimental Therapeutics 2005; 314(2): 883-890. PMID: 15901797

Song X, Lorenzi PL, Landowski CP, Vig BS, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bio-conversion, metabolic bioevasion and hPEPT1-mediated transport. Molecular Pharmaceutics 2005; 2(2): 157-167. PMID: 15804190

Landowski CP, Song X, Lorenzi PL, Hilfinger JM, Amidon GL. Floxuridine amino acid ester prodrugs: enhancing Caco-2 permeability and resistance to glycosidic bond metabolism. Pharmaceutical Research 2005; 22(9): 1510-1518. PMID: 16132363

Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL. Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(β-D-ribofuranosyl) benzimidazole (BDCRB) as potential substrates of hPEPT1 transporter. Journal of  Medical Chemistry 2005; 48(4): 1274-1277. PMID 15715497

Kim I, Song X, Vig BS, Mittal S, Shin HC, Lorenzi PJ, Amidon GL. A novel nucleoside prodrug-activating enzyme: substrate specificity of biphenyl hydrolase-like protein. Molecular Pharmaceutics 2004; 1(2): 117-127. PMID: 15832508.

Vig BS, Lorenzi PJ, Mittal S, Landowski CP, Shin H, Mosberg HI, Hilfinger JM, Amidon GL. Amino acid ester prodrugs of floxuridine: synthesis and effects of structure, stereochemistry, and site of esterification on the rate of hydrolysis. Pharmaceutical Research 2003; 20(9):1381-1388. PMID: 14567631

El-Qisairi AK, Qaseer HA, Katsigras G, Lorenzi PJ, Trivedi U, Tracz S, Hartman A, Miller JA, Henry PM. New palladium(II)-catalyzed asymmetric 1,2-dibromo synthesis. Organic Letters 2003; 5(4):439-441. PMID: 12583738

Shu C, Shen H, Teuscher NS, Lorenzi PJ, Keep RF, Smith DE. Role of PEPT2 in peptide/mimetic trafficking at the blood-CSF barrier: studies in rat choroid plexus epithelial cells in primary culture. Journal of Pharmacology and Experimental Therapeutics 2002; 301(3):820-829. PMID: 12023509

Updated April 30, 2015